SFRP1 promoter methylation and expression in human trabecular meshwork cells

Experimental Eye Research

Volumn 97, Issue 1, 2012, Pages 130-136

  Mao, Weiming ^a   Rubin, Jeffrey S ^b   Anoruo, Nancy ^b   Wordinger, Robert J ^a   Clark, Abbot F ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

5 aza 2' deoxycytidine; DNA methylation; Glaucoma; Intraocular pressure; SFRP1; Trabecular meshwork

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; GENOMIC DNA; GENOMIC RNA; SECRETED FRIZZLED RELATED PROTEIN 1;

ARTICLE; CANCER CELL; CELL CULTURE; CONTROLLED STUDY; DNA ISOLATION; DNA METHYLATION; GLAUCOMA; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; RNA ISOLATION; TRABECULAR MESHWORK;

AGED; AGED, 80 AND OVER; AZACITIDINE; CELLS, CULTURED; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA PRIMERS; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; GLAUCOMA, OPEN-ANGLE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; TRABECULAR MESHWORK;

EID: 84859502229     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2012.01.003     Document Type: Article

References (39)

1. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am. J. Ophthalmol. 2000, 130:429-440. The AGIS Investigators.
2. Baylin S.B., Ohm J.E. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat. Rev. Cancer 2006, 6:107-116.
3. Bovolenta P., Esteve P., Ruiz J.M., Cisneros E., Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted frizzled-related proteins in development and disease. J. Cell. Sci. 2008, 121:737-746.
4. Finch P.W., He X., Kelley M.J., Uren A., Schaudies R.P., Popescu N.C., Rudikoff S., Aaronson S.A., Varmus H.E., Rubin J.S. Purification and molecular cloning of a secreted, frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. U S A 1997, 94:6770-6775.
5. Fleenor D.L., Shepard A.R., Hellberg P.E., Jacobson N., Pang I.H., Clark A.F. TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2006, 47:226-234.
6. Fukui T., Kondo M., Ito G., Maeda O., Sato N., Yoshioka H., Yokoi K., Ueda Y., Shimokata K., Sekido Y. Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene 2005, 24:6323-6327.
7. Heijl A., Leske M.C., Bengtsson B., Hyman L., Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch. Ophthalmol. 2002, 120:1268-1279.
8. Inatani M., Tanihara H., Katsuta H., Honjo M., Kido N., Honda Y. Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239:109-113.
9. Jones P.A., Laird P.W. Cancer epigenetics comes of age. Nat. Genet. 1999, 21:163-167.
10. Jost E., Schmid J., Wilop S., Schubert C., Suzuki H., Herman J.G., Osieka R., Galm O. Epigenetic inactivation of secreted frizzled-related proteins in acute myeloid leukaemia. Br. J. Haematol. 2008, 142:745-753.
11. Kang S.H., Bang Y.J., Im Y.H., Yang H.K., Lee D.A., Lee H.Y., Lee H.S., Kim N.K., Kim S.J. Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer. Oncogene 1999, 18:7280-7286.
12. Kang S., Dong S.M., Park N.H. Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancer. Gynecol. Oncol. 2010, 118:58-63.
13. Kass M.A., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.L., Miller J.P., Parrish R.K., Wilson M.R., Gordon M.O. The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch. Ophthalmol. 2002, 120:701-713.
14. Levasseur R., Lacombe D., de Vernejoul M.C. LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders. Joint Bone Spine 2005, 72:207-214.
15. Licchesi J.D., Westra W.H., Hooker C.M., Machida E.O., Baylin S.B., Herman J.G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 2008, 29:895-904.
16. Lichter P.R., Musch D.C., Gillespie B.W., Guire K.E., Janz N.K., Wren P.A., Mills R.P. Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgery. Ophthalmology 2001, 108:1943-1953.
17. Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell. Dev. Biol. 2004, 20:781-810.
18. Lorente A., Mueller W., Urdangarin E., Lazcoz P., von Deimling A., Castresana J.S. Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR. BMC Cancer 2008, 8:61.
19. Mao W., Wordinger R.J., Clark A.F. Focus on molecules: SFRP1. Exp. Eye Res. 2010, 91:552-553.
20. Martens J.W., Sieuwerts A.M., Bolt-deVries J., Bosma P.T., Swiggers S.J., Klijn J.G., Foekens J.A. Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression. Thromb. Haemost. 2003, 89:393-404.
21. Munoz-Antonia T., Torrellas-Ruiz M., Clavell J., Mathews L.A., Muro-Cacho C.A., Baez A. Aberrant methylation inactivates transforming growth factor beta receptor I in head and neck squamous cell carcinoma. Int. J. Otolaryngol. 2009, 2009:848695.
22. Nojima M., Suzuki H., Toyota M., Watanabe Y., Maruyama R., Sasaki S., Sasaki Y., Mita H., Nishikawa N., Yamaguchi K., Hirata K., Itoh F., Tokino T., Mori M., Imai K., Shinomura Y. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 2007, 26:4699-4713.
23. Picht G., Welge-Luessen U., Grehn F., Lutjen-Drecoll E. Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239:199-207.
24. Pinto M., Oliveira C., Cirnes L., Carlos Machado J., Ramires M., Nogueira A., Carneiro F., Seruca R. Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas. J. Pathol. 2003, 200:32-38.
25. Rubin J.S., Barshishat-Kupper M., Feroze-Merzoug F., Xi Z.F. Secreted WNT antagonists as tumor suppressors: pro and con. Front. Biosci. 2006, 11:2093-2105.
26. Shepard A.R., Millar J.C., Pang I.H., Jacobson N., Wang W.H., Clark A.F. Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes. Invest. Ophthalmol. Vis. Sci. 2010, 51:2067-2076.
27. Smith E., Jones M.E., Drew P.A. Quantitation of DNA methylation by melt curve analysis. BMC Cancer 2009, 9:123.
28. Steely H.T., Browder S.L., Julian M.B., Miggans S.T., Wilson K.L., Clark A.F. The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1992, 33:2242-2250.
29. Suzuki H., Gabrielson E., Chen W., Anbazhagan R., van Engeland M., Weijenberg M.P., Herman J.G., Baylin S.B. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat. Genet. 2002, 31:141-149.
30. Tektas O.Y., Lutjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp. Eye Res. 2009, 88:769-775.
31. Tovar-Vidales T., Clark A.F., Wordinger R.J. Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells. Exp. Eye Res. 2011.
32. Tripathi R.C., Li J., Chan W.F., Tripathi B.J. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp. Eye Res. 1994, 59:723-727.
33. Uren A., Reichsman F., Anest V., Taylor W.G., Muraiso K., Bottaro D.P., Cumberledge S., Rubin J.S. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J. Biol. Chem. 2000, 275:4374-4382.
34. Wang W.H., McNatt L.G., Pang I.H., Millar J.C., Hellberg P.E., Hellberg M.H., Steely H.T., Rubin J.S., Fingert J.H., Sheffield V.C., Stone E.M., Clark A.F. Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J. Clin. Invest. 2008, 118:1056-1064.
35. Wojdacz T.K., Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 2007, 35. e41.
36. Wordinger R.J., Clark A.F. Bone morphogenetic proteins and their receptors in the eye. Exp. Biol. Med. (Maywood) 2007, 232:979-992.
37. Wordinger R.J., Fleenor D.L., Hellberg P.E., Pang I.H., Tovar T.O., Zode G.S., Fuller J.A., Clark A.F. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest. Ophthalmol. Vis. Sci. 2007, 48:1191-1200.
38. Wordinger R.J., Zode G., Clark A.F. Focus on molecules: gremlin. Exp. Eye Res. 2008, 87:78-79.
39. Zode G.S., Clark A.F., Wordinger R.J. Bone morphogenetic protein 4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation. Glia 2009, 57:755-766.