When you eat matters: 60 years of Franz Halberg's nutrition chronomics

Open Nutraceuticals Journal

Volumn 5, Issue 1, 2012, Pages 16-44

  Cornelissen, Germaine ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Blood pressure; Cancer; Chronobiology; Circadian; Food restriction; Lifespan; Meal timing; Starvation; Suprachiasmatic nuclei; Synchronizer; Weight

Indexed keywords

GLIBORNURIDE; GLIPIZIDE; GLUCAGON; GROWTH HORMONE; INSULIN;

AMINO ACID METABOLISM; ARTICLE; BLOOD PRESSURE; CALORIC INTAKE; CALORIC RESTRICTION; CELL DIVISION; CHRONOBIOLOGY; CIRCADIAN RHYTHM; DEATH; DEHYDRATION; DIET RESTRICTION; EATING HABIT; EOSINOPHIL COUNT; FOOD INTAKE; GLUCOSE TOLERANCE; GLYCOGEN ANALYSIS; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; LIFESPAN; MALIGNANT NEOPLASTIC DISEASE; MATURITY ONSET DIABETES MELLITUS; MEAL; NONHUMAN; NORADRENALIN UPTAKE; NUTRITION; OBESITY; PERIODICITY; PRIORITY JOURNAL; STARVATION; SUPRACHIASMATIC NUCLEUS; ULCEROGENESIS; WEIGHT CHANGE; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 84859492006     PISSN: None     EISSN: 18763960     Source Type: Journal    
DOI: 10.2174/1876396001205010016     Document Type: Article

References (188)

1. Atharva-Veda S. (written c. 3000-5000 BC). In: Lanman ChR, Ed. Whitney WD, Transl. Lanman Harvard Oriental Series, Delhi: Motilal Banarsidass 1984.
2. Brillat-Savarin JA. Aphorisms 3 and 4. In: Taste physiology, or, Meditations on transcending gastronomy. Theoretical, historical, and up-to-date work dedicated to Parisian gastronomes. Paris: A. Soutelet Co. Vol. I, 1926.
3. Virey JJ. Ephemerides of human life or research on daily revolution and periodicity of its phenomena in health and disease. Thesis. Paris: University of Paris 1814; p.39.
4. Halberg F, Cornelissen G, Katinas G, et al. Transdisciplinary unifying implications of circadian findings in the 1950s. J Circadian Rhythms 2003; 1: 61.
5. Dalton AJ, Selye H. Blood picture during alarm reaction. Folia Hematologica 1939; 62: 397-407.
6. Best WR, Muehrcke RC, Kark RM. Clinical and statistical evaluation of four-hour eosinophil response tests. J Lab Clin Med 1951; 38: 790-1.
7. Best WR, Muehrcke RC, Kark RM. Studies on adrenocortical eosinopenia: a clinical and statistical evaluation of four-hour eosinophil response test. J Clin Invest 1952; 31(7): 733-42.
8. Best WR, Kark RM, Muehrcke RC, Samter M. Clinical value of eosinophil counts and eosinophil response tests. JAMA 1953; 151(9): 702-6.
9. Halberg F, Visscher MB. Regular diurnal physiological variation in eosinophil levels in five stocks of mice. Proc Soc exp Biol (NY) 1950; 75: 846-7.
10. Halberg F, Bittner JJ, Visscher MB. Tail blood eosinophil levels in several inbred strains of mice under standard conditions. Blood 1951; 6: 832-7.
11. Halberg F, Visscher MB, Bittner JJ. Eosinophil rhythm in mice: Range of occurrence; effects of illumination, feeding and adrenalectomy. Amer J Physiol 1953; 174: 109-22.
12. Halberg F, Visscher MB. A difference between the effects of dietary calorie restriction on the estrous cycle and on the 24- hour adrenal cortical cycle in rodents. Endocrinology 1952; 51: 329-35.
13. Halberg F, Haus E, Nelson W, Sothern R. Chronopharmacology, chronodietetics and eventually clinical chronotherapy. Nova Acta leopold 1977; 46: 307-66.
14. Halberg F, Kabat HF, Klein P. Chronopharmacology: a therapeutic frontier. Am J Hosp Pharmacy 1980; 37: 101-6.
15. Halberg F, Cornelissen G, Schwartzkopff O. Introduction: Time, diagnostics, and therapeutics - beyond circadian marker rhythmguided treatment. In: Youan BC, Ed. Chronopharmaceutics: Science and technology for biological rhythm-guided therapy and prevention of diseases. Hoboken, NJ: Wiley 2009; pp. xvii-xxxii.
16. Halberg F, Cornelissen G, Schwartzkopff O. Chapter 10: Implications and applications of circadian susceptibility rhythms: chronomics and anesthesia. In: Youan BC, Ed. Chronopharmaceutics: Science and technology for biological rhythm-guided therapy and prevention of diseases. Hoboken, NJ: Wiley 2009; pp. 217-55.
17. Cornelissen G, Halberg F. Chapter 11: Treatment with open eyes: markers-guided chronotheranostics. In: Youan BC, Ed. Chronopharmaceutics: Science and technology for biological rhythm-guided therapy and prevention of diseases. Hoboken, NJ: Wiley 2009; pp. 257-323.
18. Halberg F. Chronobiology and nutrition. Contemp Nutr 1983 8 (9): 2.
19. Halberg J, Halberg E, Halberg F. Nonobese mammals pair-fed or on free-choice diets may be "what they eat" but body weight and internal circadian timing are rhythmometrically specifiable functions of "when they eat". Proc. X Int. Cong. Nutrition, Kyoto, Japan, abstract #211, 1975; p. 16.
20. Halberg F, Sullivan B. Meal schedules and their interaction with the body's schedules. Chronobiologia 1976; 3: 75-6.
21. Halberg F, Haus E, Cornelissen G. From biologic rhythms to chronomes relevant for nutrition. In: Marriott BM, Ed. Not eating enough: overcoming underconsumption of military operational rations. Washington DC: National Academy Press 1995; pp. 361-72.
22. Forsgren E. Zur Kenntnis der Histologie der Leberzellen und der Gallensekretion. Anat Anz 1918; 51: 309-14.
23. Forsgren E. On the relationship between the formation of bile and glycogen in the liver of the rabbit. Scand Arch Physiol 1928; 53: 137-51.
24. Ågren G, Wilander O, Jorpes E. Cyclic changes in the glycogen content of the liver and the muscles of rats and mice. Their bearing upon the sensitivity of the animals to insulin and their influence on the urinary output of nitrogen. Biochem J 1931: 25: 777-85.
25. Halberg F. Physiologic 24-hour periodicity; general and procedural considerations with reference to the adrenal cycle. Z Vitamin-, Hormon-u Fermentforsch 1959; 10: 225-96.
26. Ågren G. Cyclic changes in liver glycogen of rats after adrenalectomy. Biochem Z 1935; 281: 367-9.
27. Sollberger A. Diurnal changes in biological variability. Acta Anat 1955; 23: 259-87.
28. Chossat C. Recherches expérimentales sur l'inanition. Mém Acad Sci Inst Fr 1843; 8: 438.
29. Higgins GM, Berkson J, Flock E. The diurnal cycle in the liver. 1. Periodicity of the cycle with analysis of chemical constituents involved. Am J Physiol 1932; 102: 673-82; 2. Food, a factor in its determination. 1933; 105: 177-86.
30. Halberg F. Some aspects of the chronobiology of nutrition: more work is needed on "when to eat". J Nutr 1989; 119: 333-43.
31. Haus E, Halberg F. Persisting circadian rhythm in hepatic glycogen of mice during inanition and dehydration. Experientia (Basel) 1966; 22: 113-4.
32. Graeber RC, Gatty R, Halberg F, Levine H. Human eating behavior: preferences, consumption patterns and biorhythms. Technical Reports NATICK/TR-78/022 U.S. Army.1978; p. 287.
33. Bornstein A, Volker H. Uber die Schwankungen des Grundumsatzes. Z Ges Exp Med 1926; 53: 439-50.
34. Apfelbaum M, Reinberg A, Lacatis D, Abulker, Bostsarron J, Riou F. Rythme circadian de la consummation d'oxygène et du quotient respiratoire de femmes adultes jeunes en alimentation spontanée et après restriction calorique. Europ J Clin Res 1971; 16: 135-43.
35. Apfelbaum M, Bishop JS, Cressey D, et al. Human or murine endocrine and metabolic rhythms after changes in meal timing with or without a fixed activity schedule. Proc. 56th Mtg. Endocrine Society, Abstract #308, 1974.
36. Heusner A. Analysis of the 24-hour variation of energy metabolism in the white rat. D.Sc. Thesis. France: University of Strasbourg 1963.
37. Bare J. Hunger, deprivation and the day-night cycle. J Comp Physiol Psychol 1959; 52: 129-31.
38. Haus E, Hanton EM, Halberg F. 24-hour susceptibility rhythm to ethanol in fully-fed, starved and thirsted mice and the lighting regimen. Physiologist 1959; 2: 54.
39. Halberg F, Galicich F, Ungar F, French LA. Circadian rhythmic pituitary adrenocorticotropic activity, rectal temperature and pinnal mitosis of starving, dehydrated C mice. Proc Soc exp Biol (NY) 1965; 118: 414-9.
40. Galicich JH, Halberg F, French LA. Circadian adrenal cycle in C mice kept without food and water for a day and a half. Nature (Lond.) 1963; 197: 811-3.
41. Scheving LE, Nelson W, Haus E, et al. Nutrition, metabolism and prominent circadian rhythms in plasma cortisol of men on an equidistant isocaloric diet as well as during food deprivation. Proc. 55th Ann. Mtg. Endocrine Society. Endocrinology 1973; 92(Suppl 429): A-263.
42. Reinberg A. Chronobiology and nutrition. Chronobiologia 1974; 1: 22-7.
43. Reinberg A, Halberg F, Ghata J, et al. Rythme circadien de diverses fonctions physiologiques de l'homme adulte sain, actif et au repos (pouls, pression artérielle, excrétions urinaires des 17- OHCS, des catécholamines et du potassium). Test du cosinor. J Physiol (Paris) 1969; 61(Suppl. 2): 383.
44. Goetz FC, Bishop J, Halberg F, et al. Timing of single daily meal influences relations among human circadian rhythms in urinary cyclic AMP and hemic glucagon, insulin and iron. Experientia (Basel) 1976; 32: 1081-4.
45. Halberg F. Implications of biologic rhythms for clinical practice. Hosp Pract 1977; 12: 139-49.
46. Halberg F, Halberg E, Carandente F. Chronobiology and metabolism in the broader context of timely intervention and timed treatment. In: Lindenlaub E, Ed. Diabetes research today, meeting of the Minkowski Prize Winners, Symposia Medica Hoechst 12 (Capri). Stuttgart/New York: F.K. Schattauer Verlag 1976; pp. 45-95.
47. Reinberg A. Biological rhythms and energy balance in man. In: Apfelbaum M, Ed. Energy balance in man. Paris: Masson 1973; pp. 285-95.
48. Caviezel F, Cattaneo AG, Matonti S, Vigano W, Pappalettera AE, Pozza G. Single daily meal treatment in obesity. In: Enzi G, Crepaldi G, Pozza G, Renold AE, Eds. Serono Symp. #28. Obesity: Pathogenesis and Treatment. London/New York: Academic Press 1981; pp. 105-15.
49. Capani F, Carfagnini A, Consoli F, et al. Chronobiological aspects of energy expenditure in obesity. In: Enzi G, Crepaldi G, Pozza G, Renold AE, Eds. Serono Symp. #28. Obesity: Pathogenesis and treatment. London/New York: Academic Press 1981; pp. 87-103.
50. Bowen A, Reeves R. Diurnal variations in glucose tolerance. Arch Int Med 1967; 119: 261-4.
51. Gagliardino JJ, Hernandez RE. Circadian variation of the serum glucose and immunoreactive insulin levels. Endocrinology 1971; 88: 1529.
52. Lakatua DJ, Haus E, Gold EM, Halberg F. Circadian rhythm of ACTH and growth hormone in human blood. Time relations to adrenocortical blood and urinary rhythms. In: Scheving LE, Halberg F, Pauly JE, Eds. Chronobiology, Proc. Int. Soc. For the Study of Biological Rhythms, Little Rock, Ark. Tokyo: Igaku Shoin Ltd. 1974; pp. 123-129.
53. Rapoport M, Beisel W. Circadian periodicity of tryptophan metabolism. J Clin Invest 1968; 47: 934-9.
54. Wurtman R. Diurnal rhythms in mammalian protein metabolism. Mamm Protein Metab 1970; 4: 445-79.
55. Potter V, Gebert R, Pilot H, et al. Systematic oscillations in metabolic activity in rat liver and in hepatomas. I. Morris hepatoma No. 7793. Cancer Res 1966; 26: 1547-60.
56. Gagliardino JJ, Pessaq MT. Diurnal variations in the action of insulin on muscle glycogen synthesis. J Endocrinol 1974; 61: 171-7.
57. Bünning E. The physiological hour. Berlin: Springer 1958.
58. Scheving LE. The circadian influence of epidermal growth factor (EGF), insulin and glucagon on cell proliferation in the digestive tract. In: Chronobiology and the digestive system. US: NIH Publ. #84-857, 1984; pp. 41-68.
59. Scheving LE, Burns ER, Pauly JE, Tsai TH. Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium. Anat Rec 1978; 191: 479-85.
60. Hamar N. Daily changes in glucose uptake in the small intestine. Arch Ges Physiol 1940; 244: 164-70.
61. Chronobiology and the Digestive System. U.S. Department of Health and Human Services: NIH Publ. #84-857, 1984; p. 116.
62. Halberg F, Cornélissen G, Shemerovsky C. From Pavlov's time coding and conditioned reflexes to a chronophysiology of human nutrition. Rom J Physiol 1995; 32: 97-106.
63. Halberg F, Moore JG, Gibinski K, Szabo S. Further chronobiologic steps in gastroenterology. Chronobiologia 1983; 10: 409-23.
64. Markiewicz A. Chronobiological aspects of jejunum function in humans. Chronobiol Int 1992; 9: 453-61.
65. Markiewicz A, Kaminski M, Tarquini B, Halberg F. Circadian rhythm of enzymatic activity in human jejunum. Int J Chronobiol 1981; 7: 282.
66. Markiewicz A, Koszyk T, Reising J. Seasonal variations of inflammation and ulcer incidence as assessed by upper digestive tract endoscopy. Chronobiologia 1986; 13: 117-21.
67. Moore JG, Englert E Jr. Circadian rhythm of gastric acid secretion in man. Nature 1970; 226: 1261-2.
68. Moore JG, Halberg F. Circadian rhythm of gastric acid secretion in active duodenal ulcer: chronobiological statistical characteristics and comparison of acid secretory and plasma gastrin patterns with healthy subjects and post-vagotomy and pyloroplasty patients. Chronobiol Int 1987; 4: 101-10.
69. Tarquini B. Physiopathology of peptic ulcer: a new view. Rass Med sper 1980; 27: 279-302.
70. Tarquini B, Rosati I, Serantoni C. Circadian studies on gastric mitotic index in patients with duodenal ulcer and in control group. Chir Gastroent 1977; 11: 367-71.
71. Tarquini B, Lombardi P, Pernice LM, Andreoli F. Gastric continuous pH monitoring: a new apparatus in chronobiological research. In: Scheving LE, Halberg F, Ehret CF, Eds. Chronobiotechnology and chronobiological engineering. dordrecht, The Netherlands: Martinus Nijhoff 1987; pp. 390-392.
72. Gibinski K, Nowak A, Rybicka J, Czamecka K. An endoscopic study on the natural history of gastroduodenal ulcer disease. Mater med pol 1979; 11: 265-9.
73. Malinovskaya NK, Komarov FI, Rapoport SI, Voznesenskaya LA, Wetterberg L. Melatonin production in patients with duodenal ulcer. Neuroendocrinol Lett 2001; 22: 109-17.
74. Thaela MJ, Jensen MS, Cornelissen G, et al. Circadian and ultradian variation in pancreatic secretion of meal-fed pigs after weaning. J Animal Sci 1998; 76(4): 1131-9.
75. Zabielski R, Onaga T, Mineo H, Kato S. Periodic fluctuations in pancreatic secretion and duodenal motility investigated in neonatal calves. Exp Physiol 1993; 78: 675-84.
76. Zabielski R, Terui Y, Onaga T, Mineo H, Kato S. Plasma secretin fluctuates in phase with periodic pancreatic secretion and the duodenal migrating myoelectric complex in calves. Res Vet Sci 1994; 56: 332-7.
77. Bubenik GA, Pang SF, Cockshut JR, et al. Circadian variation of portal, arterial and venous blood levels of melatonin in pigs and its relationship to food intake and sleep. J Pineal Res 2000; 28: 9-15.
78. Cornelissen G, Kanabrocki E, Halberg J, Halberg F. Toward the chronobiology and chronomics of the intestine. In: Zabielski R, Gregory PC, Weström B, Eds. Biology of the intestine in growing animals. Amsterdam: Elsevier NV 2002; pp. 751-804.
79. Ader R. Gastric erosions in the rat: effects of immobilization at different points in the activity cycle. Science 1964; 145: 406-7.
80. Brown SD, Finger FW. Circadian variation of ulcer susceptibility in the rat. In: Scheving LE, Halberg F, Pauly JE, Eds. Chronobiology: Proc. Int. Soc. for the study of biological rhythms, Little Rock, Ark. Stuttgart: Georg Thieme Publishers/Tokyo: Igaku Shoin Ltd 1974; pp. 316-9.
81. Carandente F, Halberg E, Dubey DP, Beard K, Klein P, Halberg F. Chronobiology and sex as codeterminants of gastric ulcerogenesis in loaded rats of two inbred strains. In: Halberg F, Ed. Proc. XII Int. Conf. International Society for Chronobiology, Washington, D.C. Milan: Il Ponte 1977; pp. 157-66.
82. Trout DL, King SA, Bernstein PA, Halberg F, Cornelissen G. Circadian variation in the gastric-emptying response to eating in rats previously fed once or twice daily. Chronobiology Int 1991; 8: 14-24.
83. Damiola F, Minh NL, Preitner N, Kornmann B, Fleury-Olela F, Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Gene Develop 2000; 14: 2950-61.
84. Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 2001; 291: 490-2.
85. Halberg F, Visscher MB. Effect of light and of availability of food upon the 24-hour rhythm in number of circulating eosinophils in mice. Am J Physiol 1952; 171: 732.
86. Pauly JE, Burns ER, Halberg F, Tsai TS, Betterton HO, Scheving LE. Meal timing dominates lighting regimen as a synchronizer of the eosinophil rhythm in mice. Acta anat (Basel) 1975; 93: 60-8.
87. Halberg F, Cornelissen G, Haus E. Timing nutrition, both for weight gain and weight loss. Chronobiologia 1994; 21: 356-7.
88. Scheving LE, Burns ER, Pauly JE, Tsai S, Halberg F. Meal scheduling, cellular rhythms and the chronotherapy of cancer. Chronobiologia 1976; 3: 80.
89. Halberg E, Nelson W, Scheving LE, et al. Interactions of mealscheduling, lighting and housing influence the timing of circadian rhythms to a different extent at different levels of murine organization. Int J Chronobiol 1973; 1: 327-8.
90. Scheving LE, Pauly JE, Burns ER, Halberg F, Tsai S, Betterton HO. Lighting regimen dominates interacting meal schedules and synchronizes mitotic rhythm in mouse corneal epithelium. Anat Rec 1974; 180: 47-52.
91. Potter VR, Gebert RA, Pitot HC. Enzyme levels in rats adapted to 36-hour fasting. Adv Enzyme Res 1966; 4: 247-65.
92. Walker RP, Potter VR. Diurnal rhythms of hepatic enzymes from rats adapted to controlled feeding schedules. In: Scheving LE, Halberg F, Pauly JE, Eds. Chronobiology, Proc Int Soc for the study of biological rhythms, Little Rock, Ark. Tokyo: Igaku Shoin Ltd. 1974; pp. 17-22.
93. Cohn C, Joseph D, Larin F, Shoemaker WJ, Wurtman RJ. Influence of feeding habits and adrenal cortex on diurnal rhythm of hepatic tyrosine transaminase activity. Proc Soc Exp Biol Med 1970; 133: 460-2.
94. Fuller RW. Daily variation in liver tryptophan, tryptophan pyrrolase and tyrosine transaminase in rats fed ad libitum or single daily meals. Proc Soc Exp Biol Med 1970; 133: 620-2.
95. Nelson W, Nichols G, Halberg F, Kottke G. Interacting effects of lighting LD (12:12) and restricted feeding 4 hr/24 hr on circadian temperature rhythm of mice. Int J Chronobiol 1973; 1: 347.
96. Halberg E, Nelson W, Scheving LE, et al. Interactions of mealscheduling, lighting and housing influence the timing of circadian rhythms to a different extent at different levels of murine organization. Int J Chronobiol 1973; 1: 327-8.
97. Mayersbach HV, Muller O, Philippens E, Scheving LE, Steinbach G. Effect of restricted feeding schedules on various parameters of blood serum and liver of rats. Int J Chronobiol 1973; 4: 342-3.
98. Pauly JE, Burns ER, Betterton H, Tsai H, Halberg F, Scheving LE. Effect of restricted feeding schedules on blood eosinophil levels and mitotic activity as well as other parameters in mice. Int J Chronobiol 1973; 1: 348-9.
99. Halberg F, Bobb JRR, Visscher MB. Absolute numbers of circulating eosinophil blood cells in dogs starved for three days. Fed Proc 1950; 9: 54.
100. Stupfel M, Halberg E, Halberg F. L'accès alimentaire périodique des rats groupés surmonte l'alternance lumière-obscurité comme synchroniseur du rythme circadien d'émission de gaz carbonique. CR Acad Sci (Paris) 1973; 277: 873-6.
101. Katinas GS, Cornelissen G, Halberg F. Timing availability of food alters functional circadian differences within intracellular morphology of rat enterocytes. Proceedings, International Conference on the Frontiers of Biomedical Science: Chronobiology; 2006 Sept 24-26; Chengdu, China 2006; pp. 96-100.
102. Meis PJ, Hulcher FH, Rose JR, Halberg J, Halberg F. Circadian meal schedule rhythmometry on plasma triglycerides of non-human primates. Chronobiologia 1979; 6: 131-2.
103. Meis PJ, Hulcher FH, Rose JR, Halberg J, Halberg F. Individualized circadian alimentary meta (meal schedule-shift)- rhythmometry on surface temperature of nonhuman primates. Abstracts of papers, Minn. Acad. Sci., 47th Annual Spring Meeting; 1979 May 4-5; University of Minnesota, Morris 1979; pp. 18-19.
104. Meis PJ, Hulcher FH, Rose JC, Halberg J, Halberg F. Meal timing alters circadian rhythm of skin surface temperature in non-human primates. Int J Chronobiol 1980; 7: 65-76.
105. Meis PJ, Rose JC, Halberg F, Halberg J, Hulcher FH. Comparative effects of meal timing on circadian rhythms of plasma insulin and skin surface temperature in non-human primates. Chronobiologia 1983; 10: 13-9.
106. Lakatua DJ, Halberg F, Haus E, et al. Timing of single daily meals serves to manipulate relations among human circadian plasma growth hormone, cortisol, insulin and cardiovascular rhythms. Endocrinology 1976; 98, Supplement: Proc. 58th Mtg. Endocrine Soc., abstract 285, 456.
107. Halberg F. Implications of biologic rhythms for clinical practice. Hosp Pract 1977; 12: 139-49.
108. Levine H, Lakatua D, Haus E, Halberg E, Halberg F. Interpersonal and intervariable differences in meal timing effects upon circadian rhythms in pulse, blood pressure and blood hormones of presumably healthy volunteers. Physiologist 1975; 18: 289.
109. Goetz FC, Bishop J, Halberg F, et al. Timing of single daily meal influences relations among human circadian rhythms in urinary cyclic AMP and hemic glucagon, insulin and iron. Experientia (Basel) 1976; 32: 1081-4.
110. Nelson W, Cadotte L, Halberg F. Circadian timing of single daily "meal" affects survival of mice. Proc Soc exp Biol (NY) 1973; 144: 766-9.
111. Nelson W, Halberg F. Meal-timing, circadian rhythms and lifespan of mice. J Nutr 1986; 116: 2244-53.
112. Nelson W, Fundakowski R, Baer J, Cadotte L, Halberg F. An apparatus for automatically timing access of mice to food. Lab Anim Sci 1982; 31: 66-9.
113. Halberg F. On the timing of meals and drugs and the underlying physiologic mechanisms. Indian Soc Clin Exp Hypnos Newsletters 1978; 6: 1-12.
114. Halberg F, Nelson W, Lakatua D, Cadotte L, Haus E. Circadian amplitude increase associated with caloric restriction of mice by single daily meal reduced by "pattern-feeding". Notiziario SIBioC 1982; 6: 250.
115. Halberg F, Nelson W, Lakatua D, Cadotte L, Haus E. Circadian amplitude increase associated with caloric restriction of mice by single daily meal reduced by "pattern-feeding". In: Haus E, Halberg F, Eds. Chronobiology 1982-1983. Basel: S. Karger 1984; pp. 490-2.
116. Halberg F, Nelson W, Lakatua D, Cadotte L, Haus E. Circadian amplitude increase associated with caloric restriction by single daily meal reduced by "pattern-feeding" in mice. Int J Chronobiol 1981; 7: 251.
117. Nelson W, Halberg F. Schedule-shifts, circadian rhythms and lifespan of freely-feeding and meal-fed mice. Physiol Behav 1986; 38: 781-8.
118. Halberg F, Sanchez S, Nelson W. Rhythm scrambling and tumorigenesis in CD2F1 mice. In: Tarquini B, Vergassola R, Eds. III Int. Symposium, social diseases and chronobiology, Florence, Nov. 29, 1986. Rome: Istituto Italiano di Medicina Sociale 1986; pp. 59-61.
119. Halberg F, Cornelissen G, Halberg E, et al. Toward chronobiologic optimization of nutrition for cancer treatment and broad disease prevention. In: Roche AF, Ed. The role of nutrients in cancer treatment, Report of the 9th Ross Conference on Medical Research. Columbus, OH: Ross Laboratories 1991; pp. 2-9.
120. Halberg F, Haus E, Cardoso SS, et al. Toward a chronotherapy of neoplasia: Tolerance of treatment depends upon host rhythms. Experientia (Basel) 1973; 29: 909-34.
121. Nelson W, Halberg F, Scheving L. Meal timing as an adjuvant of experimental chronotherapy: circadian rhythm in tolerance of adriamycin by mice on a 24-hour cyclic lighting regimen-the usually dominant synchronizer routine-is shifted by restricting feeding to early light span. XI Int. Cancer Congress, Florence, Italy, 1974; 3: 417.
122. Halberg F, Nelson W. Chronotherapy of immunocytoma made feasible by meal timing. Proc AACR 1976; 19: 190.
123. Nelson W, Halberg F, Zinneman H, Haus E, Scheving L, Bazin H. Survival of immunocytoma-bearing rats affected by meal-feeding and timing of adriamycin treatment. In: Halberg F, Ed. Proc. XII Int. Conf. International Society for Chronobiology, Washington, D.C., 1977. Milan: Il Ponte 1977; pp. 443-7.
124. Nelson W, Halberg F, Zinneman H, Haus E, Scheving L, Bazin H. Survival of immunocytoma-bearing rats affected by meal-feeding and timing of adriamycin treatment. Chronobiologia 1975; 2(Suppl. 1): 51.
125. Yunis E, Shankaraiah K, Watson ALM, Derr LK, Halberg F. Longevity and delayed mammary carcinogenesis compatible with competing (24-hour) lighting and (48-hour) feeding schedules: internal circadian-circaduodian murine desynchronization. Int J Chronobiol 1981; 7: 347.
126. Shankaraiah K, Halberg F, Yunis E, Watson ALM. Alternate-day feeding alters the circadian system, reduces breast cancer incidence and prolongs life. In: Halberg F, Reale L, Tarquini B, Eds. Proc. 2nd Int. Conf. Medico-Social Aspects of Chronobiology, Florence, Oct. 2, 1984, Rome: Istituto Italiano di Medicina Sociale 1986; pp. 633-48.
127. Nelson W, Halberg F, Shankaraiah K. Rhythm scrambling: good, bad or indifferent? Chronobiologia 1987; 14: 291-5.
128. Yunis EJ, Watson ALM, Shankaraiah K, Halberg F. Dietary restriction and aging. Notiziario SIBioC 1982; 6: 527.
129. Halberg F, Cornelissen G, Wang ZR, et al. Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond. J Exp Therapeutics Oncol 2003; 3: 223-60.
130. Ranjana S, Rajesh SK, Mahdi AA, et al. Circadian periodicity of plasma lipid peroxides and other anti-oxidants as putative markers in gynecological malignancies. in vivo 2003; 17: 593-600.
131. Lee JY, Gillum RF, Cornelissen G, Koga Y, Halberg F. Individualized assessment of circadian rhythm characteristics of human blood pressure and pulse after moderate salt and weight restriction. In: Takahashi R, Halberg F, Walker C, Eds. Toward Chronopharmacology, Proc. 8th IUPHAR Cong. and Sat. Symposia, Nagasaki, July 27-28, 1981. Oxford/New York: Pergamon Press 1982; pp. 375-90.
132. Halberg F, Cornelissen G. I: Rhythms and blood pressure. Ann Ist Super Sanità 1993; 29: 647-55.
133. Cornelissen G, Kawasaki T, Uezono K, Delea C, Halberg F. II: Blood pressure rhythms and salt. Ann Ist Super Sanità 1993; 29: 667-77.
134. Kawasaki T, Delea CS, Bartter FC, Smith H. The effect of highsodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med 1978; 64: 193-8.
135. Bittle CC, Molina DJ, Bartter FC. Salt sensitivity in essential hypertension as determined by the cosinor method. Hypertension 1985; 7: 989-94.
136. Itoh K, Kawasaki T, Cugini P. Effects of timing of salt intake to 24-hour blood pressure and its circadian rhythm. Ann NY Acad Sci 1996; 783: 324-5.
137. Lim GB. Hypertension: salt restriction might lower blood pressure, but are there any beneficial effects on mortality? Nat Rev Cardiol 2011; 8: 479.
138. Cugini P, Lucia P, Murano G, et al. Chronobiologic effects on urinary aldosterone and related variables with a medium-term moderate reduction in salt and calorie intake. Alim Nutr Metab 1985; 6: 109-15.
139. Cugini P, Murano G, Lucia P, et al. Effects of a mild and prolonged restriction in sodium or food intake on the circadian rhythm of aldosterone and related variables. Chronobiology Int 1987; 4: 245-50.
140. Rosen G, Johnson L, Halberg F, Sargent F II. Free-running individualized circannual rhythms in human infants' weight gain and carbohydrate, fat and protein intake. Chronobiologia 1976; 3: 76-7.
141. Carandente F, Halberg E, Beard K, et al. Circadian state as well as sex determine gastric ulcerogenesis in spontaneously mesorhypertensive rats. Chronobiologia 1976; 3: 78-9.
142. Hirsch E, Halberg E, Halberg F, et al. Body weight change during 1 week on a single daily 2000-calorie meal consumed as breakfast (B) or dinner (D). Chronobiologia 1975; 2(Suppl. 1): 31-2.
143. Jacobs H, Thompson M, Halberg E, et al. Relative body weight loss on limited free-choice meal consumed as breakfast rather than dinner. Chronobiologia 1975; 2(Suppl. 1): 33.
144. Levine H, Halberg E, Halberg F, et al. Changes in internal timing of heart rate, diastolic blood pressure and certain aspects of physical and mental performance in presumably healthy subjects on different meal schedules. In: Halberg F, Ed. Proc. XII Int. Conf. International Society for Chronobiology, Washington, D.C., 1977. Milan: Il Ponte 1977; pp. 139-48.
145. Sundararaj BI, Nath P, Halberg F. Circadian meal timing in relation to lighting schedule optimizes catfish body weight gain. J Nutr 1982; 12: 1085-97.
146. Bazin H, Apfelbaum M, Assan R, et al. Redistributing proportions of food at conventional meal times reschedules differentially hormones and substrates involved in energy metabolism. Chronobiologia 1978; 5: 203.
147. Bazin R, Apfelbaum M, Assan R, et al. Circadian rhythmic energy metabolism modified by within-day food redistribution: big breakfast versus big dinner. In: Reinberg A, Halberg F, Eds. Chronopharmacology, Proc. Satellite Symp. 7th Int. Cong. Pharmacol., Paris 1978. Oxford/New York: Pergamon Press 1979; pp. 303-10.
148. Bazin H, Apfelbaum M, Assan R, Halberg F, de Gasquet P. Timing of meals manipulates amplitude and acrophase of circadian rhythms in human plasma insulin. Chronobiologia 1978; 5: 203-4.
149. Uezono K, Kawasaki T, Sasaki H, et al. Circadian biological characteristics after shifting sleep and meal times. MEFA 8th International Fair of Medical Technology and Pharmacy; 2000 Nov 7-10; Brno, Czech Republic 2000.
150. Uezono K, Kawasaki T, Sasaki H, et al. Circadian biological characteristics after shifting sleep and meal times. Scripta medica (Brno) 2002; 75: 145-50.
151. Nelson W. Food restriction, circadian disorder and longevity of rats and mice. J Nutr 1988; 118: 284-9.
152. Halberg F, Gehrke CW, Zinneman H, et al. Circadian rhythmic polyamine excretion by rats with immunocytoma. Physiologist 1976; 19: 215.
153. Anderson GE, Halberg F, Goetz FC, Haus E, Scheving LE, Bazin H. Circadian murine urinary volume, glucose, sodium and potassium characteristics manipulated by starvation in young adulthood and maturity. Chronobiologia 1979; 6: 73-4.
154. Zeman M, Stebelova K, Cornelissen G, et al. Extension of Chossat phenomena to rat plasma melatonin: increase in circadian amplitude during starvation. Noninvasive Methods in Cardiology; 2005 Sept 14; Brno, Czech Republic 2005; p. 23.
155. Nelson W, Scheving L, Halberg F. Circadian rhythms in mice fed a single daily meal at different stages of lighting regimen. J Nutr 1975; 105: 171-84.
156. Rikke BA, Yerg JE 3rd, Battaglia ME, Nagy TR, Allison DB, Johnson TE. Strain variation in the response of body temperature to dietary restriction. Mech Ageing Dev 2003; 124(5): 663-78.
157. Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006; 295(13): 1539-48.
158. Everitt AV, Le Couteur DG. Life extension by calorie restriction in humans. Ann N Y Acad Sci 2007; 1114: 428-33.
159. Smith DL, McClure JM, Matecic M, Smith JS. Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 2007; 6(5): 649-62.
160. Carrillo AE, Flouris AD. Caloric restriction and longevity: effects of reduced body temperature. Ageing Res Rev 2011; 10(1): 153-62.
161. Froy O, Miskin R. The interrelations among feeding, circadian rhythms and ageing. Prog Neurobiol 2007; 82(3): 142-50.
162. Froy O, Chapnik N, Miskin R. Relationship Between Calorie Restriction and the Biological Clock: Lessons from Long-Lived Transgenic Mice. Rejuv Res 2008; 11(2): 467-71.
163. Froy O, Miskin R. Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging 2010; 2(1): 7-27.
164. Halberg F, Halberg E, Barnum CP, Bittner JJ. Physiologic 24-hour periodicity in human beings and mice, the lighting regimen and daily routine. In: Withrow RB, Ed. Photoperiodism and related phenomena in plants and animals. Ed. Publ. No. 55. Washington DC: AAAS 1959; pp. 803-78.
165. Galicich JH, Halberg F, French LA, Ungar F. Effect of cerebral ablation on a circadian pituitary adrenocorticotropic rhythm in C mice. Endocrinology 1965; 76: 895-901.
166. Scheving LE, Tsai TS, Powell EW, Pasley JN, Halberg F, Dunn J. Bilateral lesions of suprachiasmatic nuclei affect circadian rhythms in [3H]-thymidine incorporation into deoxyribonucleic acid in mouse intestinal tract, mitotic index of corneal epithelium, and serum corticosterone. Anat Rec 1983; 205: 239-49.
167. Cornelissen G, Halberg F. Introduction to Chronobiology. Medtronic Chronobiology Seminar #7, April 1994; p. 52. (Library of Congress Catalog Card #94-060580; Avaiable at: http://www.msi.umn.edu/~halberg/)
168. Yamamoto T, Nakahata Y, Soma H, Akashi M, Mamine T, Takumi T. Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Molecular Biology 2004; 5: 18.
169. Takumi T, Yamamoto T, Cornelissen G, Hoogerwerf WA, Halberg F. Peripheral murine clock gene variation and extent of synchronization. Proceedings, International Conference on the Frontiers of Biomedical Science: Chronobiology; 2006 Sept 24-26; Chengdu, China 2006; pp. 228-31.
170. Sothern RB, Cornelissen G, Yamamoto T, Takumi T, Halberg F. Time microscopy of circadian expression of cardiac clock gene mRNA transcription: chronodiagnostic and chrono-therapeutic implications. La Clinica Terapeutica 2009; 160(2): e25-34.
171. Sothern RB, Yamamoto T, Cornelissen G, Takumi T, Halberg F. Central and peripheral circadian clock genes, their statistical analysis for rhythms, and relationship to health and disease. Scripta medica (Brno) 2009; 82: 133-63.
172. Hoogerwerf WA, Shahinian VB, Cornelissen G, et al. Rhythmic changes in colonic motility are regulated by period genes. Am J Physiol Gastrointest Liver Physiol 2010; 298: G143-50.
173. Hoogerwerf WA, Hellmich HL, Cornelissen G, et al. Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology 2007; 133: 1250-60.
174. Bostwick J, Nguyen D, Cornelissen G, Halberg F, Hoogerwerf WA. Effects of acute and chronic STZ-induced diabetes on clock gene expression and feeding in the gastrointestinal tract. Mol Cell Biochem 2010; 338(1-2): 203-13.
175. Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW. Circadian timing of food intake contributes to weight gain. Obesity 2009; 17: 2100-2.
176. Turek FW, Joshu C, Kohsaka A, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005; 308: 1043-5.
177. Kohsaka A, Laposky AD, Ramsey KM, et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 2007; 6: 414-21.
178. Ma Y, Bertone ER, Stanek EJ III, et al. Association between eating patterns and obesity in a free-living US adult population. Am J Epidemiol 2003; 158: 85-92.
179. Colles SL, Dixon JB, O'Brien PE. Night eating syndrome and nocturnal snacking: association with obesity, binge eating and psychological distress. Int J Obes (London) 2007; 31: 1722-30.
180. O'Reardon JP, Ringel BL, Dinges DF, et al. Circadian eating and sleeping patterns in the night eating syndrome. Obes Res 2004; 12: 1789-96.
181. Halberg F. Biological as well as physical parameters relate to radiology. Guest Lecture, Proc. 30th Ann. Cong. Rad., January 1977, Post-Graduate Institute of Medical Education and Research, Chandigarh, India, p. 8.
182. Halberg F, Halberg J, Halberg E, Halberg F. Chronobiology, radiobiology and steps toward the timing of cancer radiotherapy. In: Goldson AL, Volume Ed. Cancer growth and progression. vol.9, ch. 19, Kaiser H, Series Ed. Dordrecht: Kluwer Academic Publ. 1989; pp. 227-53.
183. Halberg F, Prem K, Halberg F, Norman C, Cornelissen G. Cancer Chronomics I: Origins of timed cancer treatment: early marker rhythm-guided individualized chronochemotherapy. J Exp Ther Oncol 2006; 6: 55-61.
184. Halberg F, Cornelissen G, Grambsch P, et al. Personalized chronobiologic cybercare; other chronomics' progress by transdisciplinary cycles' congruences: Season's Appreciations 2009. J Appl Biomed 2011; 9: 1-34.
185. Cornelissen G, Grambsch P, Sothern RB, Katinas G, Otsuka K, Halberg F. Congruent biospheric and solar-terrestrial cycles. J Appl Biomed 2011; 9: 63-102.
186. Halberg F. Some correlations between chemical structure and maximal eosinopenia in adrenalectomized and hypophysectomized mice. J Pharmacol exp Ther 1952; 106: 135-49.
187. Halberg F. Some physiological and clinical aspects of 24-hour periodicity. Lancet (Minneapolis) 1953; 73: 20-32.
188. Smolensky M, Halberg F, Sargent F II. Chronobiology of the life sequence. In: Itoh S, Ogata K, Yoshimura H, Eds. Advances in Climatic Physiology. Tokyo: Igaku Shoin Ltd 1972; pp. 281-318.