Analysis of Cathepsin-K activity at tooth and dental implant sites and the potential of this enzyme in reflecting alveolar bone loss

Journal of Periodontology

Volumn 83, Issue 4, 2012, Pages 498-505

  Yamalik, Nermin ^a   Günday, Sevim ^a   Uysal, Serdar ^a   Kilincx, Kamer ^a   Karabulut, Erdem ^a   Tözüm, Tolga F ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Alveolar bone loss; Cathepsin K; Dental implants; Inflammation; Tooth

Indexed keywords

BIOLOGICAL MARKER; CATHEPSIN K; CTSK PROTEIN, HUMAN;

ADULT; AGED; ALVEOLAR BONE LOSS; ARTICLE; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; ENZYMOLOGY; FEMALE; GINGIVA BLEEDING; GINGIVITIS; HUMAN; MALE; MIDDLE AGED; PERIIMPLANTITIS; PERIODONTAL POCKET; PERIODONTICS; RADIOGRAPHY; STOMATITIS; TOOTH; TOOTH IMPLANT; TOOTH PLAQUE; TOOTH RADIOGRAPHY;

ADULT; AGED; ALVEOLAR BONE LOSS; BIOLOGICAL MARKERS; CATHEPSIN K; CHRONIC PERIODONTITIS; DENTAL IMPLANTS; DENTAL PLAQUE INDEX; FEMALE; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; GINGIVITIS; HUMANS; MALE; MIDDLE AGED; PERI-IMPLANTITIS; PERIODONTAL INDEX; PERIODONTAL POCKET; RADIOGRAPHY, BITEWING; STOMATITIS; TOOTH; YOUNG ADULT;

EID: 84859486851     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.110232     Document Type: Article

References (48)

1. Mogi M, Otogoto J. Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis. Arch Oral Biol 2007;52:894-898. (Pubitemid 47125834)
2. Gendron R, Grenier D, Sorsa T, Mayrand D. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 1999;6: 437-439. (Pubitemid 29226821)
3. Soell M, Elkaim R, Tenenbaum H. Cathepsin C, matrix metalloproteinases, and their tissue inhibitors in gingiva and gingival crevicular fluid from periodontitisaffected patients. J Dent Res 2002;81:174-178.
4. Liskmann S, Zilmer M, Vihalemm T, Salum O, Fischer K. Correlation of peri-implant health and myeloperoxidase levels: A cross-sectional clinical study. Clin Oral Implants Res 2004;15:546-552. (Pubitemid 40104949)
5. Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infect Immun 1999;67: 2319-2326. (Pubitemid 29200488)
6. Beklen A, Tüter G, Sorsa T, et al. Gingival tissue and crevicular fluid co-operation in adult periodontitis. J Dent Res 2006;85:59-63. (Pubitemid 43827764)
7. Ilgenli T, Vardar-Sengul S, Gürkan A, et al. Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. Oral Dis 2006;12:573-579. (Pubitemid 44624361)
8. Mäntylä P, Stenman M, Kinane D, et al. Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase- 8-specific chair-side test. J Periodontal Res 2006;41:503-512. (Pubitemid 44656925)
9. Pollock JJ, Andors L, Gulumoglu A, Ells PF. Direct measurement of hepatitis B viral antibody and antigen markers in gingival crevicular fluid. Oral Surg Oral Med Oral Pathol 1984;57:499-503. (Pubitemid 14080667)
10. Sano K, Nakao M, Shiba A, Kobayashi K. An ultramicro- assay for proteins in biological fluids other than blood using a combination of agarose gel isoelectric focusing and silver staining. Clin Chim Acta 1984; 137:115-122. (Pubitemid 14194140)
11. Genco RJ, Zambon JJ, Murray PA. Serum and gingival fluid antibodies as adjuncts in the diagnosis of Actinobacillus actinomycetemcomitans-associated periodontal disease. J Periodontol 1985;56(Suppl. 11) 41-50.
12. Marcus ER, Jooste CP, Driver HS, Hattingh J. The quantification of individual proteins in crevicular gingival fluid. J Periodontal Res 1985;20:444-449.
13. Ohba Y, Ohba T, Terai K, Moriyama K. Expression of cathepsin K mRNA during experimental tooth movement in rat as revealed by in situ hybridization. Arch Oral Biol 2000;45:63-69. (Pubitemid 30022380)
14. Drake FH, Dodds RA, James IE, et al. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 1996;271:12511-12516. (Pubitemid 26160923)
15. Li Z, Hou WS, Brömme D. Collagenolytic activity of cathepsin K is specifically modulated by cartilageresident chondroitin sulfates. Biochemistry 2000;39: 529-536. (Pubitemid 30077626)
16. Okaji M, Sakai H, Sakai E, et al. The regulation of bone resorption in tooth formation and eruption processes in mouse alveolar crest devoid of cathepsin k. J Pharmacol Sci 2003;91:285-294. (Pubitemid 36581949)
17. Meffert RM. Periodontitis vs. peri-implantitis: The same disease? The same treatment? Crit Rev Oral Biol Med 1996;7:278-291. (Pubitemid 26363855)
18. Apse P, Ellen RP, Overall CM, Zarb GA. Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: A comparison of sites in edentulous and partially edentulous patients. J Periodontal Res 1989;24:96-105.
19. Boutros SM, Michalowicz BS, Smith QT, Aeppli DM. Crevicular fluid enzymes from endosseous dental implants and natural teeth. Int J Oral Maxillofac Implants 1996;11:322-330. (Pubitemid 126700685)
20. Jepsen S, Rühling A, Jepsen K, Ohlenbusch B, Albers HK. Progressive peri-implantitis. Incidence and prediction of peri-implant attachment loss. Clin Oral Implants Res 1996;7:133-142. (Pubitemid 126670510)
21. Plagnat D, Giannopoulou C, Carrel A, Bernard JP, Mombelli A, Belser UC. Elastase, alpha2-macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without periimplantitis. Clin Oral Implants Res 2002;13:227-233. (Pubitemid 41698459)
22. Rühling A, Jepsen S, Kocher T, Plagmann HC. Longitudinal evaluation of aspartate aminotransferase in the crevicular fluid of implants with bone loss and signs of progressive disease. Int J Oral Maxillofac Implants 1999;14:428-435.
23. Resnik RR, Kircos LT, Misch CE. Diagnostic imaging and techniques. In: Dolan J, Pendill J, Clark E, Nebel J, eds. Contemporary Implant Dentistry, 3rd ed. St. Louis: Mosby; 2008:38-67.
24. Akcxa K, Uysal S, Cxehreli MC. Implant-tooth-supported fixed partial prostheses: Correlations between in vivo occlusal bite forces and marginal bone reactions. Clin Oral Implants Res 2006;17:331-336. (Pubitemid 43709402)
25. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21:533-551.
26. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135.
27. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-235.
28. Hatipoǧlu H, Yamalik N, Berberoǧlu A, Eratalay K. Impact of the distinct sampling area on volumetric features of gingival crevicular fluid. J Periodontol 2007;78:705-715.
29. Makkonen TA, Holmberg S, Niemi L, Olsson C, Tammisalo T, Peltola J. A 5-year prospective clinical study of Astra Tech dental implants supporting fixed bridges or overdentures in the edentulous mandible. Clin Oral Implants Res 1997;8:469-475. (Pubitemid 127688536)
30. Arvidson K, Bystedt H, Frykholm A, von Konow L, Lothigius E. Five-year prospective follow-up report of the Astra Tech Dental Implant System in the treatment of edentulous mandibles. Clin Oral Implants Res 1998; 9:225-234. (Pubitemid 128657995)
31. Hellem S, Karlsson U, Almfeldt I, Brunell G, Hamp SE, Astrand P. Nonsubmerged implants in the treatment of the edentulous lower jaw: A 5-year prospective longitudinal study of ITI hollow screws. Clin Implant Dent Relat Res 2001;3:20-29.
32. Zechner W, Trinkl N, Watzak G, et al. Radiologic follow-up of peri-implant bone loss around machinesurfaced and rough-surfaced interforaminal implants in the mandible functionally loaded for 3 to 7 years. Int J Oral Maxillofac Implants 2004;19:216-221. (Pubitemid 38561058)
33. Carlsson GE, Lindquist LW, Jemt T. Long-term marginal periimplant bone loss in edentulous patients. Int J Prosthodont 2000;13:295-302.
34. Schwartz-Arad D, Mardinger O, Levin L, Kozlovsky A, Hirshberg A. Marginal bone loss pattern around hydroxyapatite- coated versus commercially pure titanium implants after up to 12 years of follow-up. Int J Oral Maxillofac Implants 2005;20:238-244. (Pubitemid 40592211)
35. Tözüm TF, Hatipoǧlu H, Yamalik N, et al. Critical steps in electronic volume quantification of gingival crevicular fluid: The potential impact of evaporation, fluid retention, local conditions and repeated measurements. J Periodontal Res 2004;39:344-357. (Pubitemid 39278533)
36. Güncü GN, Tözüm TF, Güncü MB, Yamalik N, Tümer C. A 12-month evaluation of nitrite oxide metabolism around immediate and conventionally loaded dental implants. Implant Dent 2009;18:27-37.
37. Güncü GN, Tözüm TF, Güncü MB, Yamalik N. Relationships between implant stability, image-based measures and nitric oxide levels. J Oral Rehabil 2008; 35:745-753.
38. Güncü GN, Tözüm TF, Güncü MB, et al. Myeloperoxidase as a measure of polymorphonuclear leukocyte response in inflammatory status around immediately and delayed loaded dental implants: A randomized controlled clinical trial. Clin Implant Dent Relat Res 2008;10:30-39.
39. Tözüm TF, Akman AC, Yamalik N, et al. Analysis of the inflammatory process around endosseous dental implants and natural teeth: Myeloperoxidase level and nitric oxide metabolism. Int J Oral Maxillofac Implants 2007;22:969-979.
40. Tözüm TF, Güncü GN, Yamalik N, Turkyilmaz I, Güncü MB. The impact of prosthetic design on the stability, marginal bone loss, peri-implant sulcus fluid volume, and nitric oxide metabolism of conventionally loaded endosseous dental implants: A 12-month clinical study. J Periodontol 2008;79:55-63.
41. Garg G, Pradeep AR, Thorat MK. Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis. Arch Oral Biol 2009;54: 1046-1051.
42. Strbac GD, Monov G, Cei S, Kandler B, Watzek G, Gruber R. Cathepsin K levels in the crevicular fluid of dental implants: A pilot study. J Clin Periodontol 2006; 33:302-308. (Pubitemid 43439348)
43. Tözüm TF, Türkyilmaz I, Yamalik N, et al. Analysis of the possible impact of inflammation severity and early and delayed loading on nitric oxide metabolism around dental implants. Int J Oral Maxillofac Implants 2005; 20:547-556. (Pubitemid 41549222)
44. Pradeep AR, Prapulla DV, Sharma A, Sujatha PB. Gingival crevicular fluid and serum vascular endothelial growth factor: Their relationship in periodontal health, disease and after treatment. Cytokine 2011; 54:200-204.
45. Tözüm TF, Günday S, Yamalik N. Evaluation of the peri-implant sulcus fluid (PISF) volume in response to peri-implant soft tissue inflammation. Int J Clin Dent 2009;2:195-203.
46. Kaklamanos EG, Tsalikis L. A review on peri-implant crevicular fluid assays potential in monitoring and predicting peri-implant tissue responses. J Int Acad Periodontol 2002;4:49-59.
47. Yamalik N, Günday S, Kilinc K, Karabulut E, Berker E, Tözüm TF. Analysis of cathepsin-K levels in biological fluids from healthy or diseased natural teeth and dental implants. Int J Oral Maxillofac Implants 2011; 26:991-997.
48. Mombelli A, Lang NP. Clinical parameters for the evaluation of dental implants. Periodontol 2000 1994; 4:81-86.