Cathepsin K levels in the crevicular fluid of dental implants: A pilot study

Journal of Clinical Periodontology

Volumn 33, Issue 4, 2006, Pages 302-308

  Strbac, Georg D ^a   Monov, Gabriel ^a   Cei, Silvia ^b   Kandler, Barbara ^a   Watzek, Georg ^a,c   Gruber, Reinhard ^a,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF PISA   (Italy)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Bone resorption; Cathepsin K; Crevicular fluid; Immunoassay; Peri implantitis

Indexed keywords

CATHEPSIN; CATHEPSIN K; CYSTEINE PROTEINASE; PROTEIN;

ADULT; AGE; AGED; ARTICLE; CHEMISTRY; ENZYMOLOGY; FEMALE; GINGIVA BLEEDING; GINGIVITIS; HUMAN; MALE; MANDIBLE; MAXILLA; MIDDLE AGED; OSTEOLYSIS; PERIODONTICS; PERIODONTITIS; PILOT STUDY; SEX DIFFERENCE; TOOTH IMPLANTATION; TOOTH PLAQUE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALVEOLAR BONE LOSS; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DENTAL IMPLANTS; DENTAL PLAQUE INDEX; FEMALE; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; HUMANS; MALE; MANDIBLE; MAXILLA; MIDDLE AGED; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PILOT PROJECTS; PROTEINS; SEX FACTORS;

EID: 33645112144     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2006.00904.x     Document Type: Article

References (54)

1. Ataoglu H. Alptekin NO. Haliloglu S. Gursel M. Ataoglu T. Serpek B. Durmus E. 2002 Interleukin-1beta, tumor necrosis factor-alpha levels and neutrophil elastase activity in peri-implant crevicular fluid Clinical Oral Implants Research 13 470 476
2. Bossard MJ. Tomaszek TA. Thompson SK. Amegadzie BY. Hanning CR. Jones C. Kurdyla JT. McNulty DE. Drake FH. Gowen M. Levy MA. 1996 Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification Journal of Biological Chemistry 271 12517 12524
3. Boyle WJ. Simonet WS. Lacey DL. 2003 Osteoclast differentiation and activation Nature 423 337 342
4. Buchmann R. Hasilik A. Van Dyke TE. Lange DE. 2002 Amplified crevicular leukocyte activity in aggressive periodontal disease Journal of Dental Research 81 716 721
5. Buhling F. Waldburg N. Gerber A. Hackel C. Kruger S. Reinhold D. Bromme D. Weber E. Ansorge S. Welte T. 2000 Cathepsin K expression in human lung Advances in Experimental Medicine and Biology 477 281 286
6. Bullon P. Fioroni M. Goteri G. Rubini C. Battino M. 2004 Immunohistochemical analysis of soft tissues in implants with healthy and peri-implantitis condition, and aggressive periodontitis Clinical Oral Implants Research 15 553 559
7. Chambers TJ. 2000 Regulation of the differentiation and function of osteoclasts Journal of Pathology 192 4 13
8. Chaytor DV. Zarb GA. Schmitt A. Lewis DW. 1991 The longitudinal effectiveness of osseointegrated dental implants. The Toronto study bone level changes International Journal of Periodontics Restorative Dentistry 11 112 125
9. Chen HY. Cox SW. Eley BM. 1998 Cathepsin B, alpha2-macroglobulin and cystatin levels in gingival crevicular fluid from chronic periodontitis patients Journal of Clinical Periodontology 25 34 41
10. Cox JF. Zarb GA. 1987 The longitudinal clinical efficacy of osseointegrated dental implants a 3-year report International Journal of Oral Maxillofacial Implants 2 91 100
11. De Smet E. van Steenberghe D. Quirynen M. Naert I. 2001 The influence of plaque and/or excessive loading on marginal soft and hard tissue reactions around Branemark implants a review of literature and experience International Journal of Periodontics Restorative Dentistry 21 381 393
12. Dickinson DP. 2002 Cysteine peptidases of mammals their biological roles and potential effects in the oral cavity and other tissues in health and disease Critical Reviews in Oral Biology and Medicine 13 238 275
13. Dodds RA. James IE. Rieman D. Ahern R. Hwang SM. Connor JR. Thompson SD. Veber DF. Drake FH. Holmes S. Lark MW. Gowen M. 2001 Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption Journal of Bone and Mineral Research 16 478 486
14. Esposito M. Hirsch JM. Lekholm U. Thomsen P. 1998 Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology European Journal of Oral Science 106 527 551
15. Gowen M. Lazner F. Dodds R. Kapadia R. Feild J. Tavaria M. Bertoncello I. Drake F. Zavarselk S. Tellis I. Hertzog P. Debouck C. Kola I. 1999 Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization Journal of Bone and Mineral Research 14 1654 1663
16. Griffiths GS. 2003 Formation, collection and significance of gingival crevice fluid Periodontology 2000 31 32 42
17. Griffiths GS. Sterne JA. Wilton JM. Eaton KA. Johnson NW. 1992 Associations between volume and flow rate of gingival crevicular fluid and clinical assessments of gingival inflammation in a population of British male adolescents Journal of Clinical Periodontology 19 464 470
18. Gualini F. Berglundh T. 2003 Immunohistochemical characteristics of inflammatory lesions at implants Journal of Clinical Periodontology 30 14 18
19. Ida-Yonemochi H. Ishibashi O. Sakai H. Saku T. 2004 Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice European Journal of Oral Science 112 148 155
20. Kaklamanos EG. Tsalikis L. 2002 A review on peri-implant crevicular fluid assays potential in monitoring and predicting peri-implant tissue responses Journal of International Academy Periodontology 4 49 59
21. Kivela-Rajamaki M. Maisi P. Srinivas R. Tervahartiala T. Teronen O. Husa V. Salo T. Sorsa T. 2003a Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid Journal of Periodontal Research 38 583 590
22. Kivela-Rajamaki MJ. Teronen OP. Maisi P. Husa V. Tervahartiala TI. Pirila EM. Salo TA. Mellanen L. Sorsa TA. 2003b Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid Clinical Oral Implants Research 14 158 165
23. Kiviranta R. Morko J. Uusitalo H. Aro HT. Vuorio E. Rantakokko J. 2001 Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K Journal of Bone and Mineral Research 16 1444 1452
24. Kourtis SG. Sotiriadou S. Voliotis S. Challas A. 2004 Private practice results of dental implants. Part I survival and evaluation of risk factors Part II: surgical and prosthetic complications Implant Dentistry 13 373 385
25. Lam J. Takeshita S. Barker JE. Kanagawa O. Ross FP. Teitelbaum SL. 2000 TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand Journal of Clinical Investigation 106 1481 1488
26. Lindeman JH. Hanemaaijer R. Mulder A. Dijkstra PD. Szuhai K. Bromme D. Verheijen JH. Hogendoorn PC. 2004 Cathepsin K is the principal protease in giant cell tumor of bone American Journal of Pathology 165 593 600
27. Liskmann S. Zilmer M. Vihalemm T. Salum O. Fischer K. 2004 Correlation of peri-implant health and myeloperoxidase levels a cross-sectional clinical study Clinical Oral Implants Research 15 546 552
28. Littlewood-Evans AJ. Bilbe G. Bowler WB. Farley D. Wlodarski B. Kokubo T. Inaoka T. Sloane J. Evans DB. Gallagher JA. 1997 The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma Cancer Research 57 5386 5390
29. Ma J. Kitti U. Hanemaaijer R. Teronen OP. Sorsa TA. Natah S. Tensing EK. Konttinen YT. 2003 Gelatinase B is associated with peri-implant bone loss Clinical Oral Implants Research 14 709 713
30. Marinello CP. Berglundh T. Ericsson I. Klinge B. Glantz PO. Lindhe J. 1995 Resolution of ligature-induced peri-implantitis lesions in the dog Journal of Clinical Periodontology 22 475 479
31. Mombelli A. Lang NP. 1994 Clinical parameters for the evaluation of dental implants Periodontology 2000 4 81 86
32. Mombelli A. van Oosten MA. Schurch E. Jr. Land NP. 1987 The microbiota associated with successful or failing osseointegrated titanium implants Oral Microbiology and Immunology 2 145 151
33. Murata M. Tatsumi J. Kato Y. Suda S. Nunokawa Y. Kobayashi Y. Takeda H. Araki H. Shin K. Okuda K. Miyata T. Yoshie H. 2002 Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis Clinical Oral Implants Research 13 637 643
34. Nishi Y. Atley L. Eyre DE. Edelson JG. Superti-Furga A. Yasuda T. Desnick RJ. Gelb BD. 1999 Determination of bone markers in pycnodysostosis effects of cathepsin K deficiency on bone matrix degradation Journal of Bone and Mineral Research 14 1902 1908
35. Oringer RJ. Palys MD. Iranmanesh A. Fiorellini JP. Haffajee AD. Socransky SS. Giannobile WV. 1998 C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants Clinical Oral Implants Research 9 365 373
36. Pjetursson BE. Tan K. Lang NP. Bragger U. Egger M. Zwahlen M. 2004 A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years Clinical Oral Implants Research 15 625 642
37. Rantakokko J. Aro HT. Savontaus M. Vuorio E. 1996 Mouse cathepsin K cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development FEBS Letters 393 307 313
38. Rieman DJ. McClung HA. Dodds RA. Hwang SM. Holmes MW. James IE. Drake FH. Gowen M. 2001 Biosynthesis and processing of cathepsin K in cultured human osteoclasts Bone 28 282 289
39. Saftig P. Hunziker E. Wehmeyer O. Jones S. Boyde A. Rommerskirch W. Moritz JD. Schu P. von Figura K. 1998 Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice Proceedings of the National Academy of Science USA 95 13453 13458
40. Salvi GE. Lang NP. 2004 Diagnostic parameters for monitoring peri-implant conditions International Journal of Oral Maxillofacial Implants 19 Suppl. 116 127
41. Skoumal M. Haberhauer G. Kolarz G. Hawa G. Woloszczuk W. Klingler A. 2005 Serum cathepsin K levels of patients with longstanding rheumatoid arthritis correlation with radiological destruction Arthritis Research Therapy 7 R65 R70
42. Soell M. Elkaim R. Tenenbaum H. 2002 Cathepsin C, matrix metalloproteinases, and their tissue inhibitors in gingiva and gingival crevicular fluid from periodontitis-affected patients Journal of Dental Research 81 174 178
43. Suda T. Takahashi N. Udagawa N. Jimi E. Gillespie MT. Martin TJ. 1999 Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families Endocrine Reviews 20 345 357
44. Teitelbaum SL. 2000 Bone resorption by osteoclasts Science 289 1504 1508
45. Teitelbaum SL. Ross FP. 2003 Genetic regulation of osteoclast development and function Nature Reviews Genetics 4 638 649
46. Tervahartiala T. Konttinen YT. Ingman T. Hayrinen-Immonen R. Ding Y. Sorsa T. 1996 Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis Journal of Clinical Periodontology 23 68 75
47. Tillmanns HW. Hermann JS. Cagna DR. Burgess AV. Meffert RM. 1997 Evaluation of three different dental implants in ligature-induced peri-implantitis in the beagle dog. Part I. Clinical evaluation International Journal of Oral Maxillofacial Implants 12 611 620
48. Tonetti MS. Schmid J. 1994 Pathogenesis of implant failures Periodontology 2000 4 127 138
49. Trabandt A. Muller-Ladner U. Kriegsmann J. Gay RE. Gay S. 1995 Expression of proteolytic cathepsins B, D, and L in periodontal gingival fibroblasts and tissues Laboratory Investigation 73 205 212
50. Tsuji Y. Yamaza T. Kido MA. Goto T. Nakata S. Akamine A. Nakasima A. Tanaka T. 2001 Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy Cell Tissue Research 303 359 369
51. Wang D. Li W. Pechar M. Kopeckova P. Bromme D. Kopecek J. 2004 Cathepsin K inhibitor-polymer conjugates potential drugs for the treatment of osteoporosis and rheumatoid arthritis International Journal of Pharmaceutics 277 73 79
52. Wei S. Kitaura H. Zhou P. Ross FP. Teitelbaum SL. 2005 IL-1 mediates TNF-induced osteoclastogenesis Journal of Clinical Investigation 115 282 290
53. Yamashita DS. Dodds RA. 2000 Cathepsin K and the design of inhibitors of cathepsin K Current Pharmaceutical Design 6 1 24
54. Zitzmann NU. Berglundh T. Ericsson I. Lindhe J. 2004 Spontaneous progression of experimentally induced periimplantitis Journal of Clinical Periodontology 31 845 849