P16 ink4a and p15 ink4b gene promoter methylation in cervical cancer patients

Oncology Letters

Volumn 3, Issue 6, 2012, Pages 1331-1335

  Jha, Abhimanyu Kumar ^a   Nikbakht, Mohsen ^a   Jain, Veena ^b   Capalash, Neena ^a   Kaur, Jagdeep ^a  

^a PANJAB UNIVERSITY   (India)

^b Mohan Dai Oswal Cancer Treatment and Research Foundation   (India)

Author keywords

CpG island; Human papillomavirus; Methylation specific PCR; Promoter hypermethylation; Reverse transcription PCR

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; MESSENGER RNA;

ADULT; AGE; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE PROMOTER METHYLATION; HUMAN; INDIAN; MAJOR CLINICAL STUDY; METHYLATION; ORAL CONTRACEPTION; PAPILLOMAVIRUS INFECTION; PASSIVE SMOKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX CANCER;

EID: 84859476021     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.655     Document Type: Article

References (29)

1. Globocan 2008: http://www.dep.iarc.fr/globocan/database.htm.
2. Burd EM: Human papillomavirus and cervical cancer. Clin Microbiol Rev 16: 1-17, 2003.
3. Virmani AK, Muller C, Rathi A, Zoechbauer-Mueller S, Mathis M and Gazdar AF: Aberrant methylation during cervical carcinogenesis. Clinical Cancer Res 7: 584-589, 2001.
4. Hirama T and Koeffer HP: Role of the cyclin dependent kinase inhibitors in the development of cancer. Blood 86: 841-854, 1995.
5. Hannon GJ and Beach D: P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371: 257-261, 1994.
6. Liggett WH Jr and Sidransky D: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 16: 1197-1206, 1998.
7. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB and Sidransky D: 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692, 1995.
8. Zhang SJ, Endo S, Ichikawa T, Washiyama K and Kumanishi T: Frequent deletion and 5 CpG island methylation of the p16 gene in primary malignant lymphoma of the brain. Cancer Res 58: 1231-1237, 1998.
9. Esteller M, Corn PG, Baylin SB and Herman JG: A gene hypermeth-ylation profile of human cancer. Cancer Res 61: 3225-3229, 2001.
10. Rocco JW and Sidransky D: P16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 264: 42-55, 2001.
11. Feng Q, Balasubramanian A, Hawes SE, Toure P, Sow PS, Dem A, Dembele B, Critchlow CW, Xi L, Lu H, McIntosh MW, Young AM and Kiviat NB: Detection of hypermethylated genes in women with and without cervical neoplasia. J Natl Cancer Inst 97: 273-282, 2005.
12. D'Costa J, Saranath D, Dedhia P, Sanghvi V and Mehta RA: Detection of HPV-16 genome in human oral cancers and potentially malignant lesions from India. Oral Oncol 34: 413-420, 1998.
13. Park JS, Dong SM, Kim HS, Lee JY, Jong Um S, Park IS, Kim SJ and Namkoong SE: Detection of p16 gene alteration in cervical cancer using tissue microdissection and LOH study. Cancer Lett 136: 101-108, 1999.
14. Yeh KT, Chang GA, Lin TH, Wang YF, Tien N, Chang JY, Chen CJ and Shih MC: Epigenetics changes of tumor suppressor genes, p15, p16, VHIL and p53 in oral cancer. Oncol Rep 10: 659-663, 2003.
15. Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB and Herman JG: Hypermethylation-associated inactivation of p14ARF is independent of p16INK4a methylation and p53 mutational status. Cancer Res 60: 129-133, 2000.
16. Herman JG, Jen J, Merlo A and Baylin SB: Hypermethylation associated inactivation indicates a tumor suppressor role for p15INK4b. Cancer Res 56: 722-727, 1996.
17. Perrone F, Tabano S, Colombo F, Dagrada G, Birindelli S, Gronchi A, Colecchia M, Pierotti MA and Pilotti S: p15INK4b, p14ARF and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. Clinical Cancer Research 9: 4132-4138, 2003.
18. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ and Muñoz N: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189: 12-19, 1999.
19. Tay SK and Tay, KJ: Passive cigarette smoking is a risk factor for cervical neoplasia. Gynecol Oncol 93: 116-120, 2004.
20. Louie KS, de Sanjose S, Diaz M, Castellsagué X, Herrero R, Meijer CJ, Shah K, Franceschi S, Muñoz N, Bosch FX; International Agency for Research on Cancer Multicenter Cervical Cancer Study Group: Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. Br J Cancer 100: 1191-1197, 2009.
21. Jha AK, Nikbakht M, Parashar G, Shrivastava A, Capalash N and Kaur J: Reversal of hypermethylation and reactivation of the RARβ2 gene by natural compounds in cervical cancer lines. Folia Biol (Praha) 56: 195-200, 2010.
22. Jha AK, Kumar S, Nikbakht M, Sharma V and Kaur J: Epigenetics and its role in ageing and cancer. J Med Med Sci 2: 696-713, 2011.
23. Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M and Murty VV: Frequent promoter methylation of CDH1, DAPK, RARβ and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer 2: 24, 2003.
24. Ishida E, Nakamura M, Ikuta M, Shimada K, Matsuyoshi S, Kirita T and Konishi N: Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma. Oral Oncol 41: 614-622, 2005.
25. Kurakawa E, Shimamoto T and Utsumi K: Hypermethylation of p16INK4a and p15INK4b gene in non-small cell lung cancer. Int J Oncol 19: 277-281, 2001.
26. Jeong DH, Youm MY, Kim NY, Lee KB, Sung MS, Yoon HK and Kim KT: Promoter methylation of p16, DAPK, CDH1 and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics. Int J Gynecol Cancer 16: 1234-1240, 2006.
27. Tripathi A, Banerjee S, Roy A, Roychowdhury S and Panda CK: Alterations of the p16 gene in uterine cervical carcinoma from Indian patients. Int J Gynecol Cancer 13: 472-479, 2003.
28. Attaleb M, El hamadani W, Khyatti M, Benbacer L, Benchekroun N, Benider A, Amrani M and El Mzibri M: Status of p16INK4a and E-cadherin gene promoter methylation in Moroccan patients with cervical carcinoma. Oncol Res 184: 185-192, 2009.
29. Lea JS, Coleman R, Kurien A, Schorge JO, Miller SD, Minna JD and Muller YC: Aberrant p16 methylation is a biomarker for tobacco exposure in cervical squamous cell carcinogenesis. Am J Obstet Gynecol 190: 674-679, 2004.