Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 13, 2012, Pages 4992-4997

  Oyoshi, Michiko K ^a   He, Rui ^a,e   Kanaoka, Yoshihide ^b,c   ElKhal, Abdallah ^a   Kawamoto, Seiji ^d   Lewis, Christopher N ^a   Austen, K Frank ^b,c   Geha, Raif S ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HIROSHIMA UNIVERSITY   (Japan)

^e FUDAN UNIVERSITY   (China)

Author keywords

Eicosanoid; Murine model of atopic dermatitis

Indexed keywords

COLLAGEN; LEUKOTRIENE C4; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE RECEPTOR; MESSENGER RNA; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BONE MARROW; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DISEASE MODEL; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; HYPERKERATOSIS; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLERGY; SKIN FIBROBLAST; SKIN FIBROSIS; SKINFOLD;

ADOPTIVE TRANSFER; ANIMALS; CELL PROLIFERATION; COLLAGEN; DERMATITIS, ATOPIC; DERMIS; DISEASE MODELS, ANIMAL; EOSINOPHILS; FIBROSIS; GATA TRANSCRIPTION FACTORS; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNIZATION; KERATINOCYTES; LEUKOTRIENE C4; MICE; OVALBUMIN; RECEPTORS, LEUKOTRIENE; SIGNAL TRANSDUCTION; SKIN;

MURINAE; MUS;

EID: 84859467879     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203127109     Document Type: Article

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