Synthesis and structure of the β-carboline derivatives and their binding intensity with cyclin-dependent kinase 2

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 4, 2012, Pages 435-441

  Wang, Yue ^a,b   Jin, Qiaomei ^a   Lin, Guowu ^a   Yang, Taotao ^a   Wang, Zhanwei ^a   Lu, Yi ^a   Tang, Yimin ^a   Liu, Lifang ^a   Lu, Tao ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

carboline; Cyclin dependent kinase 2; Fluorescence; Molecular docking; Synthesis

Indexed keywords

1 CARBAMOYL 6 AMINOSULFONYL BETA CARBOLINE; 3 CYCLOHEXYLMETHOXY; 6 AMINOSULFONYL 1 CARBAMOYL 3 (1H BENZO[D]IMIDAZOL 2 YL)BETA CARBOLINE; 6 AMINOSULFONYL 1 CARBAMOYL 3 CYCLOHEXYLMETHOXY BETA CARBOLINE; 6 AMINOSULFONYL 1 CARBAMOYL 3 METHOXY BETA CARBOLINE; 6 AMINOSULFONYL 1 N METHYLCARBAMOYL BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ENZYME BINDING; FLUORESCENCE ANALYSIS; FLUORESCENCE SPECTROSCOPY; HYDROPHOBICITY; MOLECULAR DOCKING; SUBSTITUTION REACTION; SYNTHESIS;

BINDING SITES; CARBOLINES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE;

EID: 84859454350     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.60.435     Document Type: Article

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