Cdk pathway: Cyclin-dependent kinases and cyclin-dependent kinase inhibitors

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 19, Issue 2, 2001, Pages 179-188

  Gitig, D M ^a   Koff, A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cdk (cyclin dependent kinase); cki (cyclin dependent kinase inhibitor); Coimmunoprecipitation; Cyclin; FACS(fluorescent activated cell sorting); Immunoblot (Western blot); Kinase assay

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; DNA; PROTEIN P21; PROTEIN P27;

ARTICLE; CELL CYCLE; COMPLEX FORMATION; ENZYME ACTIVITY; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL SEPARATION; COLORING AGENTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA; ENZYME INHIBITORS; FLOW CYTOMETRY; GLUTATHIONE TRANSFERASE; IMMUNOBLOTTING; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PRECIPITIN TESTS; PROPIDIUM; PROTEIN KINASES; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; THYMIDINE; TUMOR SUPPRESSOR PROTEINS;

EID: 0034778671     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:19:2:179     Document Type: Article

References (14)

1. Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
2. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β
3. Inactivation of a cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
4. Formation of p27-cdk complexes during the human mitotic cell cycle
5. Requirement of cyclin E-cdk2 inhibition in p16Ink4a-mediated growth suppression
6. Human T-cell leukemia virus type 1 Tax and cell cycle progression: Role of cyclin D-cdk and p110Rb
7. Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
8. Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
9. Cooperating oncogenes converge to regulate cyclin/cdk complexes
10. The regulation of E2F by pRB-family proteins