Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2764-2767

  Ramani, Addepalli Venkata ^a   Monika, Arumalla ^a   Indira, Vadlamani Lakshmi ^a   Karyavardhi, Gopisetti ^a   Venkatesh, Jangala ^a   Jeankumar, Variam Ullas ^a   Manjashetty, Thimmappa H ^a   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Anti mycobacterial activity; Anti TB activity; Isoniazid analogue; Tuberculosis

Indexed keywords

3 MERCAPTOPROPIONIC ACID; ISONIAZID; N[2 [4 (BENZYLOXY)PHENYL] 4 OXO 1,3 THIAZINAN 3 YL]ISONICOTINAMIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ONE POT SYNTHESIS; PLASMA CLEARANCE; RAT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTITUBERCULAR AGENTS; HEP G2 CELLS; HUMANS; INJECTIONS, INTRAVENOUS; ISONIAZID; MALE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; RATS; RATS, WISTAR;

MYCOBACTERIUM TUBERCULOSIS; RATTUS NORVEGICUS;

EID: 84859445703     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.091     Document Type: Article

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