In vitro antimycobacterial activities of 2′-monosubstituted isonicotinohydrazides and their cyanoborane adducts

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 2, 2002, Pages 294-299

  Maccari, Rosanna ^a   Ottanà, Rosaria ^a   Monforte, Francesca ^a   Vigorita, Maria Gabriella ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; ISONIAZID; ISONIAZID DERIVATIVE; RIFAMPICIN;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CYTOTOXICITY; DRUG SAFETY; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; BORANES; HUMANS; ISONIAZID; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS;

EID: 0036146574     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.2.294-299.2002     Document Type: Article

References (33)

1. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
2. Isoniazid-related copper(II) and nickel(II) complexes with antimycobacterial in vitro activity
3. Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes
4. Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance
5. Mycobacterial disease, immunosuppression, and acquired immunodeficiency syndrome
6. Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
7. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
8. Synthetic tuberculostats. IX. Dialkyl derivatives of isonicotinylhydrazine
9. Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar blue assay
10. Effect of isoniazid chemoprophylaxis on HIV-related mycobacterial disease
11. Randomised trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection
12. The Mycobacterium avium complex
13. Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis
14. Antimycobacterial agents
15. Antimicrobial agents used in the chemotherapy of tuberculosis
16. Antitubercular substances. II. Substitution products of isonicotinic hydrazide
17. Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium
18. Biosynthesis of the linkage region of the mycobacterial cell wall
19. Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis
20. Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: Restricted array of mutations associated with drug resistance
21. Synthesis of mono- and di-cyanoborane adducts from isonicotinoylhydrazones and sodium cyanoborohydride
22. Binding of catalase-peroxidase-activated isoniazid to wild-type and mutant Mycobacterium tuberculosis enoyl-ACP reductases
23. Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis
24. Modification of the NADH of the isoniazid target (inhA) from Mycobacterium tuberculosis
25. Antimycobacterial agents
26. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions
27. Multidrugresistant tuberculosis in patients without HIV infection
28. Halogenated isoniazid derivatives as possible antitubercular and antineoplastic agents
29. Halogentaed isoniazid derivatives as possible antimycobacterial and anti-HIV agents
30. 2-1,3,4-oxadiazolines from isonicotinoylhydrazones and diazomethane as potential antimycobacterial and anti-HIV agents
31. Lipophilic analogs of isoniazid with antiproliferative in vitro activity
32. Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis
33. The catalaseperoxidase gene and isoniazid resistance of Mycobacterium tuberculosis