A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-o-desmethyl donepezil in human plasma and its pharmacokinetic application

Biomedical Chromatography

Volumn 25, Issue 8, 2011, Pages 943-951

  Pilli, Nageswara Rao ^a   Inamadugu, Jaswanth Kumar ^b   Kondreddy, Neeraja ^b   Karra, Vijaya Kumari ^a   Damaramadugu, Rajasekhar ^b   Rao, J V L N Seshagiri ^c  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b SRI VENKATESWARA UNIVERSITY   (India)

^c ANDHRA UNIVERSITY   (India)

Author keywords

6 o desmethyl donepezil; Donepezil; Human plasma; LC MS MS; Quantification

Indexed keywords

HEXANE; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

6-O-DESMETHYL DONEPEZIL; ACTIVE METABOLITES; ASSAY METHODS; DONEPEZIL; HUMAN PLASMAS; LC-MS-MS; LC.MS/MS; QUANTIFICATION; TANDEM MASS SPECTROMETRIC;

LIQUID CHROMATOGRAPHY;

6 O DESMETHYL DONEPEZIL; ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM FORMATE; DIPYRIDAMOLE; DONEPEZIL; DRUG METABOLITE; HEXANE; UNCLASSIFIED DRUG;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHASE TRANSITION; PLASMA CONCENTRATION-TIME CURVE; TANDEM MASS SPECTROMETRY;

EID: 79959934441     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1552     Document Type: Article

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