Determination of donepezil hydrochloride (E2020) in plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studies in healthy, young, Chinese subjects

Journal of Chromatographic Science

Volumn 42, Issue 5, 2004, Pages 234-237

  Lu, Yihong ^a   Wen, Hongmei ^b   Li, Wei ^b   Chi, Yumei ^b   Zhang, Zhengxing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; DONEPEZIL; HEXANE; LORATADINE; METHANOL;

ADULT; ALKALINIZATION; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CHINESE; DRUG DETERMINATION; EXTRACTION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RELIABILITY; VOLUNTEER;

EID: 2442676721     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/42.5.234     Document Type: Article

References (7)

1. M. Mihara, A. Ohnishi, Y. Tomono, J. Hasegana, Y. Shimamura, K. Yamazaki, and N. Morishita. Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers. Int. J. Clin. Pharmacol. Ther. Toxicol. 31: 223-29 (1993).
2. J.P. Rho and L.G. Lipson. Focus on donepezil: a reversible acetyl-cholinesterase inhibitor for the treatment of Alzheimer's disease. Formulary 32: 677-78 (1997).
3. S.L. Rogers, R.S. Doody, R.C. Mohs, and L.T. Friedhoff. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Arch. Intern. Med. 158: 1021-31 (1998).
4. S.L. Rogers and L.T. Friedhoff. Pharmacokinetic and pharmacodymic profile of donepezil HCl following single oral doses. Br. J. Clin. Pharmacol. 46: 1-6 (1998).
5. S.L. Rogers, N.M. Cooper, R. Sukovaty, J.E. Pederson, and J.N. Lee. Pharmacodymic profile of donepezil HCl following multiple oral doses. Br. J. Clin. Pharmacol. 46: 7-12 (1998).
6. A. Ohnishi, M. Mihara, H. Kamakura, Y. Tomano, J. Hasegawa, K. Yamazaki, N. Morishita, and T. Tanaka. Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects. J. Clin. Pharmacol. 33: 1086-91 (1993).
7. J. Haginaka and C. Seyama. Determination of enantiomers of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methylpiperidine hydrochloride(E2020),a centrally acting acetylcholine esterase inhibitor, in plasma by liquid chromatography with fluorometric detection. J. Chromatogr. 577: 95-102 (1992).