Induction of apoptosis by type Iβ protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468

Cell Biochemistry and Function

Volumn 30, Issue 3, 2012, Pages 183-190

  Fallahian, Faranak ^a   Karami Tehrani, Fatemeh ^a   Salami, Siamak ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Cyclic GMP; MCF 7; MDA MB 468; Protein kinase G

Indexed keywords

8 BROMO CYCLIC GMP; CASPASE 3; CASPASE 9; CYCLIC GMP DEPENDENT PROTEIN KINASE; LIPOCORTIN 5; PROPIDIUM IODIDE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASE 8; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FEMALE; HUMANS;

EID: 84859441136     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1831     Document Type: Article

References (28)

1. Pfeifer A, Ruth P, Dostmann W, Sausbier M, Klatt P, Hofmann F. Structure and function of cGMP-dependent protein kinases. Rev Physiol Biochem Pharmacol 1999; 135: 105-149.
2. Francis SH, Corbin JD. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit Rev Clin Lab Sci 1999; 36: 275-328.
3. Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M. Characterization of the human gene encoding the type Iα and type Iβ cGMP-dependent protein kinase (PKGI). Genomics 1997; 42: 311-318.
4. Orstavik S, Solberg R, Tasken K, et al. Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Biochem Biophys Res Commun 1996; 220: 759-765.
5. Wolfe L, Corbin JD, Francis SH. Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta. J Biol Chem 1989; 264: 7734-7741.
6. Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J Biol Chem 1995; 270: 27380-27388.
7. Vaandrager AB, Edixhoven M, Bot AG, et al. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can be functionally distinguished from the type I isoforms. J Biol Chem 1997; 272: 11816-11823.
8. Lohmann SM, Vaandrager AB, Smolenski A, Walter U, De Jonge HR. Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci 1997; 22: 307-312.
9. Lohmann SM, Fischmeister R, Walter U. Signal transduction by cGMP in heart. Basic Res Cardiol 1991; 86: 503-514.
10. Uhler MD. Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem 1993; 268: 13586-13591.
11. Jarchau T, Hausler C, Markert T, et al. Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Proc Natl Acad Sci 1994; 91: 9426-9430.
12. Shimojo T, Hiroe M, Ishiyama S, Ito H, Nishikawa T, Marumo F. Nitric oxide induces apoptotic death of cardiomyocytes via a cyclic-GMP-dependent pathway. Exp Cell Res 1999; 247: 38-47.
13. Loweth AC, Williams GT, Scarpello JH, Morgan NG. Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett 1997; 400: 285-288.
14. Kaminski A, Gao H, Morgan NG. Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS Lett 2004; 559: 118-124.
15. Cook AL, Haynes JM. Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cell Signal 2004; 16: 253-261.
16. Chiche JD, Schlutsmeyer SM, Bloch DB, De la Monte SM, Roberts JD. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP. J Biol Chem 1998; 273: 34263-34271.
17. Deguchi A, Thompson WJ, Weinstein IB. Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. Cancer Res 2004; 64: 3966-3973.
18. Browning DD. cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment. Future Med Chem 2010; 2: 65-80.
19. Browning DD. Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer. Expert Opin Biol Ther 2008; 8: 1-10.
20. Fallahian F, Karami-Tehrani F, Salami S, Aghaei M. Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines. FEBS J 2011; 278: 3360-3369.
21. Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R, Weinstein IB. Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. J Biol Chem 2001; 276: 16406-16410.
22. Schwede F, Marondeb E, Genieser HG, Jastorff B. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacol Ther 2000; 87: 199-226.
23. Smolenski A, Schultess J, Danielewski O, et al. Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics 2004; 83: 577-587.
24. Fischer TA, Palmetshofer A, Gambaryan S, et al. Activation of cGMP dependent protein kinase Iβ inhibits interleukin 2 release and proliferation of T cell receptor-stimulated human peripheral T cells. J Biol Chem 2001; 276: 5967-5974.
25. Sekhar KR, Hatchett RJ, Shabb JB, et al. Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type Iα, compared with type Iβ, cGMP-dependent protein kinase. Mol Pharmacol 1992; 42: 103-108.
26. Pöhler D, Butt E, Meibner J, et al. Expression, purification, and characterization of the cGMP-dependent protein kinases Iβ and II using the baculovirus system. FEBS Lett 1995; 374: 419-425.
27. Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 required for DNA fragmentation; and morphological changes associated with apoptosis. J Biol Chem 1998; 273: 9357-9360.
28. Deguchi A, K. Das K, W. Xing S, Oehlen B. Weinstein IB. Down-regulation of the cGMP/PKG pathway in primary human colon cancers and cancer cell lines. Proc Amer Assoc Cancer Res 2005; 46: 56-68.