Synthesis and comparative assessment of a labeled RGD peptide bearing two different 99mTc-tricarbonyl chelators for potential use as targeted radiopharmaceutical

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2549-2557

  Psimadas, Dimitrios ^a,c   Fani, Melpomeni ^a,d   Gourni, Eleni ^a,e   Loudos, George ^b   Xanthopoulos, Stavros ^a   Zikos, Christos ^a   Bouziotis, Penelope ^a   Varvarigou, Alexandra D ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b UNIVERSITY OF WEST ATTICA   (Greece)

^c UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^d UNIVERSITY OF FREIBURG   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chelator; Integrin; Radiolabeling; Radiopharmaceutical; RGD; Technetium

Indexed keywords

3 CYSTEINE PROPIONIC ACID; CYCLIC ARGINYLGLYCYLASPARTYL DEXTRO PHENYLALANYLLYSINE; RADIOPHARMACEUTICAL AGENT; TRICARBONYL CHELATOR TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME DEGRADATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; MOUSE; NONHUMAN; SCINTIGRAPHY; TISSUE HOMOGENATE;

ANIMALS; CHELATING AGENTS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; ISOTOPE LABELING; MICE; MICE, SCID; MOLECULAR CONFORMATION; OLIGOPEPTIDES; ORGANOTECHNETIUM COMPOUNDS; QUALITY CONTROL; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

MUS;

EID: 84859435887     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.051     Document Type: Article

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