Study of the labeling of two novel RGD-peptidic derivatives with the precursor [99mTc(H2O)3(CO)3] + and evaluation for early angiogenesis detection in cancer

Applied Radiation and Isotopes

Volumn 64, Issue 2, 2006, Pages 151-159

  Psimadas, D ^a,b   Fani, M ^a,b   Zikos, C ^a,b   Xanthopoulos, S ^b   Archimandritis, S C ^b   Varvarigou, A D ^b  

^a Biomedica Life Sciences SA   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Angiogenesis; Carbonyls; Integrins; RGD; Technetium

Indexed keywords

ANGIOGRAPHY; BLOOD; DERIVATIVES; PROTEINS; TECHNETIUM; TUMORS;

ANGIOGENESIS; CARBONYLS; RGD SEQUENCES; URINARY SYSTEM;

RADIOTHERAPY;

ARGINYLGLYCYLASPARTIC ACID; TECHNETIUM 99M;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER; CANCER STAGING; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HEPATOBILIARY SYSTEM; ISOTOPE LABELING; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRECURSOR; PRIORITY JOURNAL; RADIOCHEMISTRY; URINARY TRACT;

ANIMALS; FEMALE; ISOTOPE LABELING; MICE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TECHNETIUM COMPOUNDS; TISSUE DISTRIBUTION;

EID: 28044458160     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2005.06.010     Document Type: Article

References (35)

1. - in aqueous solution and its reaction with a bifunctional ligand J. Am. Chem. Soc. 120 1998 7987 7988
2. 99mTc- carbonyls Biopolymers 76 2004 324 333
3. B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J.D. Watson Molecular Biology of the Cell 3rd ed 1994 Garland Publishing
4. 3 blocks human breast cancer growth and angiogenesis in human skin J. Clin. Invest. 96 1995 1815 1822
5. 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy Bioconj. Chem. 13 2002 1226 1237
6. P. Carmeliet, and R.K. Jain Angiogenesis in cancer and in other diseases Nature 407 2000 249 257
7. M. Cristofanilli, C. Charnsangavej, and G.N. Hortobagui Angiogenesis modulation in cancer research: novel clinical approaches Nature Rev. 1 2002 415 426
8. 99m somatostatin analogues: effect of labelling methods and peptide sequence Eur. J. Nucl. Med. 26 1999 869 876
9. 99mTc-aquaion labels peptide to an unprecedented high specific activity J. Nucl. Med. 40 1999 1913 1917
10. ν integrins during angiogenesis: insights into potential mechanisms of action and clinical development J. Clin. Invest. 103 1999 1227 1230
11. J. Folkman, L.M. Sherwood, and E.E. Parris Tumour angiogenesis: therapeutic implications New Engl. J. Med. 285 1971 1182 1186
12. S.B. Fox, G. Gasparini, and A.L. Harris Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs Lancet Oncol. 2 2001 278 289
13. A.L. Harris Antiangiogenesis for cancer therapy Lancet 349 1997 SII13 SII15
14. 3 integrin antagonists: class of tracers for tumour targeting J. Nucl. Med. 40 1999 1061 1071
15. 18F-labeled RGD-containing glycopeptide and positron emission tomography Cancer Res. 61 2001 1781 1785
16. R. Haubner, H.J. Wester, F. Burkhart, R. Senekowitsch-Schmidtke, W. Weber, S.L. Goodman, H. Kessler, and M. Schwaiger Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics J. Nucl. Med. 42 2001 326 336
17. 3 Integrin "Vitronectin Receptor" Int. J. Biochem. Cell Biol. 29 1997 721 725
18. 3 integrin binding peptides in a nude mouse model Cancer Res. 62 2002 6146 6151
19. U.E. Knies, and A.L. Harris Hypoxia signaling in tumour angiogenesis Emerg. Therap. Targets 4 2000 361 375
20. 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP(2)) chelate Appl. Radiat. Isotopes 58 2003 543 549
21. 99mTc(I)-postlabeled high affinity bombesin analogue as a potential tumor imaging agent Bioconj. Chem. 13 2002 599 604
22. 99mTc-labeled neuropeptide Y analogues as potential tumor imaging agents Bioconj. Chem. 12 2001 1028 1034
23. S. Liekens, E. De Clercq, and J. Neyts Angiogenesis: regulators and clinical applications J. Biochem. Pharmacol. 61 2001 253 270
24. 99mTc Quart. J. Nucl. Med. 40 1996 221 233
25. M. Ogawa, K. Hatano, S. Oishi, Y. Kawasumi, N. Fujii, M. Kawaguchi, R. Doi, M. Imamura, M. Yamamoto, K. Ajito, T. Mukai, H. Saji, and K. Ito Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo alpha(v)beta3 integrin related tumor imaging Nucl. Med. Biol. 30 2003 1 9
26. D. Psimadas, and P. Bouziotis Angiogenesis in cancer and its detection with radiolabeled biomolecules Hellenic J. Nucl. Med. 8 2005 5 11
27. 99m(I) and evaluation of new RGD-peptidic derivatives for early angiogenesis detection in cancer Eur. J. Nucl. Med. Molec. Imag. 31 2004 S393
28. E. Ruoslahti, and M.D. Pierschbacher New perspectives in cell adhesion: RGD and integrins Science 238 1987 491 497
29. 99mTc-tricarbonyl complexes: a hint for the future fictionalization of biomolecules Bioconj. Chem. 11 2000 345 351
30. 99m labeled RGD-containing synthetic peptide Eur. J. Nucl. Med. 25 1998 1383 1389
31. 99m)Tc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO)(3)] (APPA=[(5-amino-pentyl)-pyridin-2-yl-methyl-amino]-acetic acid) Nucl. Med. Biol. 30 2003 465 470
32. C.M. Storgard, D.G. Stupack, A. Jonczyk, S.L. Goodman, R.I. Fox, and D.A. Cheresh Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist J. Clin. Invest. 103 1999 47 54
33. P.M. Van Hagen, W.A.P. Breeman, H.F. Bernard, M. Schaar, C.M. Mooyj, A. Srinivasan, M.A. Schmidt, E.P. Krenning, and M. de Jong Evaluation of a radiolabeled cyclic DTPA-RGD analogue for tumour imaging and radionuclide therapy Int. J. Cancer (Radi. Oncol. Invest.) 90 2000 186 198
34. C.C. Zikos, and N.G. Ferderigos (R,S)2-fluoro(chloro)-4′-carboxy- triphenyl methanol-novel acid-labile trityl type handles for solid-phase peptide-synthesis Tetrahedron Lett. 35 1994 1767 1768
35. C.C. Zikos, E. Livaniou, L. Leondiadis, N. Ferderigos, D.S. Ithakissios, and G.P. Evangelatos Comparative evaluation of four trityl-type amidomethyl polystyrene resins in Fmoc solid phase peptide synthesis J. Pept. Sci. 9 2003 419 429