N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: Structure-activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes

Peptides

Volumn 34, Issue 2, 2012, Pages 433-446

  Gera, Lajos ^a   Roy, Caroline ^b   Bawolak, Marie Thérèse ^b   Charest Morin, Xavier ^b   Marceau, François ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Angiotensin converting enzyme; Bradykinin receptors; Cell imaging; Fluorescent ligands; Receptor endocytosis; Structure activity relationship

Indexed keywords

6 CARBOXYFLUORESCEIN; AMINOCAPROIC ACID; BRADYKININ ANTAGONIST; BRADYKININ RECEPTOR; BRADYKININ RECEPTOR AGONIST; CARBOXYLIC ACID; CETIRIZINE; CHLORAMBUCIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; FLUORESCEIN ISOTHIOCYANATE;

ACYLATION; AMINO ACID SEQUENCE; CALCIUM MOBILIZATION; CELL GROWTH; CHEMICAL STRUCTURE; CYTOTOXICITY; EPIFLUORESCENCE MICROSCOPY; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RECEPTOR AFFINITY; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION;

6-AMINOCAPROIC ACID; BINDING, COMPETITIVE; CELL MEMBRANE; ENDOSOMES; FLUORESCEINS; FLUORESCENT DYES; HEK293 CELLS; HUMANS; LIGANDS; MOLECULAR IMAGING; OLIGOPEPTIDES; PEPTIDYL-DIPEPTIDASE A; RECEPTORS, BRADYKININ; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859433492     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.02.007     Document Type: Review

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