Lyophilised ready-to-use formulations of PEG-PCL-PEI nano-carriers for siRNA delivery

International Journal of Pharmaceutics

Volumn 428, Issue 1-2, 2012, Pages 121-124

  Endres, Thomas ^a   Zheng, Mengyao ^a   Beck Broichsitter, Moritz ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Cationic triblock copolymer; Freeze drying; Gene delivery; Nano carrier; siRNA

Indexed keywords

MACROGOL; NANOCARRIER; POLY(ETHYLENE IMINE); POLYCAPROLACTONE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; LYOPHILISATE; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; REHYDRATION;

CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; FREEZE DRYING; GENE TRANSFER TECHNIQUES; GLUCOSE; HUMANS; NANOPARTICLES; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; RNA, SMALL INTERFERING; SUSPENSIONS; TRANSFECTION;

EID: 84859433313     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.03.003     Document Type: Article

References (18)

1. W. Abdelwahed, G. Degobert, S. Stainmesse, and H. Fessi Freeze-drying of nanoparticles formulation, process and storage considerations Adv. Drug Deliv. Rev. 58 2006 1688 1713 (Pubitemid 44827432)
2. M.Ã. Andersen, K.A. Howard, S.R. Paludan, F. Besenbacher, and J. Kjems Delivery of siRNA from lyophilized polymeric surfaces Biomaterials 29 2008 506 512 (Pubitemid 350103802)
3. M. Beck-Broichsitter, E. Rytting, T. Lebhardt, X. Wang, and T. Kissel Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the "ouzo region" upon drug loading Eur. J. Pharm. Sci. 41 2010 244 253
4. B. Brissault, C. Leborgne, C. Guis, O. Danos, H. Cheradame, and A. Kichler Linear topology confers in vivo gene transfer activity to polyethylenimines Bioconjug. Chem. 17 2006 759 765 (Pubitemid 43794387)
5. C. Brus, E. Kleemann, A. Aigner, F. Czubayko, and T. Kissel Stabilization of oligonucleotide-polyethylenimine complexes by freeze-drying: physicochemical and biological characterization J. Control. Release 95 2004 119 131 (Pubitemid 38167686)
6. J.M. Chan, L. Zhang, K.P. Yuet, G. Liao, J.W. Rhee, R. Langer, and O.C. Farokhzad PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery Biomaterials 30 2009 1627 1634
7. T.K. Endres, M. Beck-Broichsitter, O. Samsonova, T. Renette, and T.H. Kissel Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery Biomaterials 32 2011 7721 7731
8. D.J. Gary, N. Puri, and Y.Y. Won Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery J. Control. Release 121 2007 64 73 (Pubitemid 47126065)
9. L.D. Hahn, H. Kong, and D.J. Mooney Polycation structure mediates expression of lyophilized polycation/pDNA complexes Macromol. Biosci. 10 2010 1210 1215
10. J. Jeong, T. Park, and S. Kim Self-assembled and nanostructured siRNA delivery systems Pharm. Res. 28 2011 2072 2085
11. A.K. Kundu, P.K. Chandra, S. Hazari, G. Ledet, Y.V. Pramar, S. Dash, and T.K. Mandal Stability of lyophilized siRNA nanosome formulations Int. J. Pharm. 423 2011 525 534
12. C.Q. Mao, J.Z. Du, T.M. Sun, Y.D. Yao, P.Z. Zhang, E.W. Song, and J. Wang A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy Biomaterials 32 2011 3124 3133
13. C. Packhaeuser, K. Lahnstein, J. Sitterberg, T. Schmehl, T. Gessler, U. Bakowsky, W. Seeger, and T. Kissel Stabilization of aerosolizable nano-carriers by freeze-drying Pharm. Res. 26 2009 129 138
14. S.W. Poxon, and J.A. Hughes The effect of lyophilization on plasmid DNA activity Pharm. Dev. Technol. 5 2000 115 122 (Pubitemid 30069206)
15. M. Reinisalo, A. Urtti, and P. Honkakoski Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells J. Control. Release 110 2006 437 443 (Pubitemid 41827498)
16. A. Wieber, T. Selzer, and J. Kreuter Physico-chemical characterisation of cationic DOTAP liposomes as drug delivery system for a hydrophilic decapeptide before and after freeze-drying Eur. J. Pharm. Biopharm. 80 2011 358 368
17. P. Yadava, M. Gibbs, C. Castro, and J. Hughes Effect of lyophilization and freeze-thawing on the stability of siRNA-liposome complexes AAPS PharmSciTech 9 2008 335 341
18. J. Yu, and T.J. Anchordoquy Synergistic effects of surfactants and sugars on lipoplex stability during freeze-drying and rehydration J. Pharm. Sci. 98 2009 3319 3328