Linear topology confers in vivo gene transfer activity to polyethylenimines

Bioconjugate Chemistry

Volumn 17, Issue 3, 2006, Pages 759-765

  Brissault, B ^a   Leborgne, C ^b   Guis, C ^a   Danos, O ^b   Cheradame, H ^a   Kichler, A ^b  

^a UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; TOPOLOGY;

GENE DELIVERY; GENE TRANSFER ACTIVITY; GENES EXPRESSION; IN-VIVO; LINEAR TOPOLOGY; POLY(ETHYLENIMINE); PROPERTY; REPORTER-GENE EXPRESSION; TRANSFECTION ACTIVITY; TRANSFECTION AGENTS;

GENE TRANSFER;

AMINE; LUCIFERASE; POLYETHYLENEIMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG; MOUSE; NONHUMAN; REPORTER GENE;

EID: 33646900167     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc050287v     Document Type: Article

References (17)

1. Kichler, A., Behr, J. P., and Erbacher, P. (1999) Polyethylenimines: a family of potent polymers for nucleic acid delivery, in Nonviral Vectors for Gene Therapy (Huang, L., Hung, M. C., and Wagner, E., Eds.) pp 191-206, Academic Press, San Diego.
2. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92, 7297-7301.
3. Zou, S. M., Erbacher, P., Remy, J. S., and Behr, J. P. (2000) Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J. Gene Med. 2, 128-34.
4. Bragonzi, A., Boletta, A., Biffi, A., Muggia, A., Sersale, G., Cheng, S. H., Bordignon, C., Assael, B. M., and Conese, M. (1999) Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs. Gene Ther. 6, 1995-2004.
5. Goula, D., Benoist, C., Mantero, S., Merlo, G., Levi, G., and Demeneix, B. A. (1998) Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 5, 1291-1295.
6. Goula, D., Remy, J. S., Erbacher, P., Wasowicz, M., Levi, G., Abdallah, B., and Demeneix, B. A. (1998) Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 5, 712-717.
7. Brissault, B., Kichler, A., Guis, C., Leborgne, C., Danos, O., and Cheradame, H. (2003) Synthesis of linear polyethylenimine derivatives for DNA transfection. Bioconjugate Chem. 14, 581-587.
8. Kichler, A., Leborgne, C., Coeytaux, E., and Danos, O. (2001) Polyethylenimine-mediated gene delivery: a mechanistic study. J. Gene Med. 3, 135-144.
9. Guis, C., and Cheradame, H. (2000) Synthesis of polymers containing pseudohalide groups by cationic polymerization. Study of the functionalizing living cationic polymerization of 2-methyloxazoline in the presence of trimethylsilylazide. Eur. Polym. J. 36, 2581-2590.
10. Frump, J. A. (1971) Oxazoline. Their preparation, reactions, and applications. Chem. Rev. 71, 483-505.
11. Saegusa, T., Kobayashi, S., and Yamada, A. (1976) Kinetics and mechanism of isomerization polymerization of 2-methyl-2-oxazoline by benzyl chloride and bromide initiators. Effect of halogen counteranions. Makromol. Chem. 177, 2271-2283.
12. 13C NMR study of structure of polyethylenimine. Eur. Polym. J. 9, 559-565.
13. Demeneix, B. A., and Behr, J. P. (1996) The proton sponge: a trick the viruses didn't exploit, in Artificial Self-Assembling Systems for Gene Delivery (Behr, J. P., Felgner, P., Heller, R., Lehn, P., and Szoka, F. C., Eds.) pp 146-152, American Chemical Society Books, Washington, DC.
14. Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M., and Tashiro, Y. (1991) Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 266, 17707-17712.
15. Wightman, L., Kircheis, R., Rossler, V., Carotta, S., Ruzicka, R., Kursa, M., and Wagner, E. (2001) Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J. Gene Med. 3, 362-372.
16. Ogris, M., Steinlein, P., Kursa, M., Mechtler, K., Kircheis, R., and Wagner, E. (1998) The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5, 1425-1433.
17. Tang, M. X., Redemann, C. T., and Szoka, F. C., Jr. (1996) In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjugate Chem. 7, 703-714.