A leaf methanolic extract of Wercklea insignis attenuates the lipopolysaccharide-induced inflammatory response by blocking the NF-κB signaling pathway in RAW 264.7 macrophages

Inflammation

Volumn 35, Issue 1, 2012, Pages 321-331

  Park, Ji Won ^a,b   Kwon, Ok Kyoung ^a   Jang, Ha Young ^a   Jeong, Hyeok ^a   Oh, Sei Ryang ^a   Lee, Hyeong Kyu ^a   Han, Sang Bae ^b   Ahn, Kyung Seop ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Inflammation; MAPK; NF B; Nitric oxide; Wercklea insignis

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WERCKLEA INSIGNIS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; MACROPHAGE; MALVACEAE; MOUSE; NONHUMAN; PAW EDEMA; PLANT LEAF; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WERCKLEA INSIGNIS; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALVACEAE; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84859431563     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9322-8     Document Type: Article

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