Multiple pathways for the irreversible inhibition of steroid sulfatase with quinone methide-generating suicide inhibitors

ChemBioChem

Volumn 10, Issue 9, 2009, Pages 1457-1461

  Ahmed, Vanessa ^a   Liu, Yong ^a   Taylor, Scott D ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Breast cancer therapy; Cance; Inhibitors; Steroid sulfatase; Steroids

Indexed keywords

ESTRONE SULFATE DERIVATIVE; HYMECROMONE SULFATE; QUINONE DERIVATIVE; QUINONE METHIDE; STERYL SULFATASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROLYSIS; PRIORITY JOURNAL;

ENZYME INHIBITORS; INDOLEQUINONES; KINETICS; STERYL-SULFATASE;

EID: 70349559654     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900143     Document Type: Article

References (20)

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13. An alternative explanation for the lag phase and results with β-ME is that quinone methide 9 is accumulating then entering the active site and inhibiting STS. However, it is very unlikely that such a highly reactive species would accumulate in solution to any appreciable extent.
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