The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: A cohort study

Osteoarthritis and Cartilage

Volumn 20, Issue 5, 2012, Pages 388-395

  Larsson, S ^a   Englund, M ^a,b   Struglics, A ^a   Lohmander, L S ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Aggrecan; Aggrecanase; Biomarkers; Meniscus injury; Osteoarthritis; Patient reported Outcome

Indexed keywords

AGGRECAN; AGGRECANASE;

ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IMMUNOASSAY; JOINT CAVITY; KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MENISCECTOMY; OSTEOPHYTE; OUTCOME ASSESSMENT; PATELLOFEMORAL JOINT; PRIORITY JOURNAL; RATING SCALE; SYNOVIAL FLUID LEVEL; TREATMENT OUTCOME;

ADULT; AGED; AGGRECANS; BIOLOGICAL MARKERS; COHORT STUDIES; DISEASE PROGRESSION; ENDOPEPTIDASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KNEE INJURIES; MALE; MENISCI, TIBIAL; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PEPTIDE FRAGMENTS; POSTOPERATIVE PERIOD; PROGNOSIS; SEX FACTORS; SYNOVIAL FLUID;

EID: 84859423872     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.02.001     Document Type: Article

References (39)

1. Flores R.H., Hochberg M.C. Definition and classification of osteoarthritis. Osteoarthritis 2003, 1-8. Oxford University Press, Oxford. K.D. Brandt, M. Doherty, L.S. Lohmander (Eds.).
2. Rousseau J.C., Delmas P.D. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 2007, 3:346-356.
3. Kraus V.B., Burnett B., Coindreau J., Cottrell S., Eyre D., Gendreau M., et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 2011, 19:515-542.
4. Fosang A.J., Rogerson F.M. Identifying the human aggrecanase. Osteoarthritis Cartilage 2010, 18:1109-1116.
5. Englund M., Roos E.M., Lohmander L.S. Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls. Arthritis Rheum 2003, 48:2178-2187.
6. Lohmander L.S., Ostenberg A., Englund M., Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum 2004, 50:3145-3152.
7. Roos E.M. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol 2005, 17:195-200.
8. Lohmander L.S., Englund P.M., Dahl L.L., Roos E.M. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 2007, 35:1756-1769.
9. Larsson S., Lohmander L.S., Struglics A. Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study. Arthritis Res Ther 2009, 11:R92.
10. Struglics A., Larsson S., Hansson M., Lohmander L.S. Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases. Osteoarthritis Cartilage 2009, 17:497-506.
11. Larsson S., Englund M., Struglics A., Lohmander L.S. Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis. Arthritis Res Ther 2010, 12:R230.
12. Roos E.M., Roos H.P., Lohmander L.S., Ekdahl C., Beynnon B.D. Knee Injury and Osteoarthritis Outcome Score (KOOS)-development of a self-administered outcome measure. J Orthop Sports Phys Ther 1998, 28:88-96.
13. Roos E.M., Roos H.P., Ekdahl C., Lohmander L.S. Knee injury and Osteoarthritis Outcome Score (KOOS)-validation of a Swedish version. Scand J Med Sci Sports 1998, 8:439-448.
14. Struglics A., Larsson S., Pratta M.A., Kumar S., Lark M.W., Lohmander L.S. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 2006, 14:101-113.
15. Tortorella M.D., Burn T.C., Pratta M.A., Abbaszade I., Hollis J.M., Liu R., et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999, 284:1664-1666.
16. Englund M., Lohmander L.S. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 2004, 50:2811-2819.
17. Altman R.D., Hochberg M., Murphy W.A., Wolfe F., Lequesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 1995, 3(Suppl A):3-70.
18. Englund M., Lohmander L.S. Patellofemoral osteoarthritis coexistent with tibiofemoral osteoarthritis in a meniscectomy population. Ann Rheum Dis 2005, 64:1721-1726.
19. Roos EM. Knee Injury and Osteoarthritis Outcome Score (KOOS). http://www.koos.nu.
20. Roos E.M., Lohmander L.S. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 2003, 1:64.
21. Deaver D.R. A new non-isotopic detection system for immunoassays. Nature 1995, 377:758-760.
22. Pratta M.A., Su J.L., Leesnitzer M.A., Struglics A., Larsson S., Lohmander L.S., et al. Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. Osteoarthritis Cartilage 2006, 14:702-713. 23.
23. Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005, 434:644-648.
24. Stanton H., Rogerson F.M., East C.J., Golub S.B., Lawlor K.E., Meeker C.T., et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005, 434:648-652.
25. Sandy J.D., Flannery C.R., Neame P.J., Lohmander L.S. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest 1992, 89:1512-1516.
26. Lohmander L.S., Neame P.J., Sandy J.D. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum 1993, 36:1214-1222.
27. Arner E.C., Hughes C.E., Decicco C.P., Caterson B., Tortorella M.D. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. Osteoarthritis Cartilage 1998, 6:214-228.
28. Little C.B., Flannery C.R., Hughes C.E., Mort J.S., Roughley P.J., Dent C., et al. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. Biochem J 1999, 344(Pt 1):61-68. 29.
29. Struglics A., Hansson M., Lohmander L.S. Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains. Osteoarthritis Cartilage 2011, 19:1047-1057.
30. Chockalingam P., Sun W., Rivera-Bermudez M., Zeng W., Dufield D., Larsson S., et al. Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage 2011, 19:315-323.
31. Rizkalla G., Reiner A., Bogoch E., Poole A.R. Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. J Clin Invest 1992, 90:2268-2277.
32. Lohmander L.S., Ionescu M., Jugessur H., Poole A.R. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 1999, 42:534-544.
33. Dieppe P.A., Lohmander L.S. Pathogenesis and management of pain in osteoarthritis. Lancet 2005, 365:965-973.
34. Snow D.M., Brown E.M., Letourneau P.C. Growth cone behavior in the presence of soluble chondroitin sulfate proteoglycan (CSPG), compared to behavior on CSPG bound to laminin or fibronectin. Int J Dev Neurosci 1996, 14:331-349.
35. Chan C.C., Roberts C.R., Steeves J.D., Tetzlaff W. Aggrecan components differentially modulate nerve growth factor-responsive and neurotrophin-3-responsive dorsal root ganglion neurite growth. J Neurosci Res 2008, 86:581-592.
36. Malfait A.M., Ritchie J., Gil A.S., Austin J.S., Hartke J., Qin W., et al. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage 2010, 18:572-580.
37. Felson D.T., Chaisson C.E., Hill C.L., Totterman S.M., Gale M.E., Skinner K.M., et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001, 134:541-549.
38. Englund M., Guermazi A., Roemer F.W., Yang M., Zhang Y., Nevitt M.C., et al. Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Ann Rheum Dis 2010, 69:1796-1802.
39. Simkin P.A., Bassett J.E. Cartilage matrix molecules in serum and synovial fluid. Curr Opin Rheumatol 1995, 7:346-351.