Constitutively active glutaminase variants provide insights into the activation mechanism of anthranilate synthase

Biochemistry

Volumn 51, Issue 13, 2012, Pages 2812-2818

  List, Felix ^a   Bocola, Marco ^a   Haeger, Michaela C ^a   Sterner, Reinhard ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE SITE; ACTIVITY REGULATION; ANTHRANILATE SYNTHASE; CARBOXAMIDES; CATALYTIC CYSTEINES; CONCERTED REACTIONS; CONSTITUTIVELY ACTIVES; ENZYME COMPLEXES; GLUTAMINASE; IMIDAZOLE GLYCEROL PHOSPHATES; METABOLIC PATHWAYS; MOLECULAR DYNAMICS SIMULATIONS; NUCLEOPHILIC ATTACK; RATE-LIMITING STEPS; SIDE-CHAINS; SITE DIRECTED MUTAGENESIS; STEADY-STATE KINETICS; STRUCTURAL PERTURBATION; SULFHYDRYL GROUPS; SYNTHASES; THIOESTERS; WILD TYPES;

GLYCEROL; HYDROLYSIS; MOLECULAR DYNAMICS; REACTION INTERMEDIATES; REACTION KINETICS;

AMINO ACIDS;

ANTHRANILATE SYNTHASE; CYSTINE; GLUTAMINASE; GLYCEROPHOSPHATE; HYDROLYASE; HYDROXYLAMINE; IMIDAZOLE; THIOL GROUP;

ARTICLE; ASSAY; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEADY STATE;

ANTHRANILATE SYNTHASE; BIOCATALYSIS; ENZYME ACTIVATION; GLUTAMINASE; MOLECULAR DYNAMICS SIMULATION;

EID: 84859408822     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201618v     Document Type: Article

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