Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment

Journal of Biochemistry

Volumn 151, Issue 4, 2012, Pages 353-359

  Yamanashi, Yuji ^a   Tezuka, Tohru ^a   Yokoyama, Kazumasa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

cancer; cytohesin; Dok 7; myasthenia; neuromuscular junction

Indexed keywords

AGRIN; ALPHA ACTIN; CYTOHESIN 1; DOK 7 PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; MUSK PROTEIN; PROTEIN SH2; PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

AMINO TERMINAL SEQUENCE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CRYSTAL STRUCTURE; CYTOPLASM; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; JUXTAMEMBRANE; LOSS OF FUNCTION MUTATION; MYASTHENIA; MYOBLAST; MYOTUBE; NEUROMUSCULAR SYNAPSE; NONHUMAN; NONSENSE MUTATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; CYTOPLASM; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MOLECULAR TARGETED THERAPY; MUSCLE PROTEINS; MYASTHENIA GRAVIS; MYOBLASTS; NEOPLASMS; NEUROMUSCULAR JUNCTION; PROTEIN BINDING; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 84859357364     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs013     Document Type: Review

References (34)

1. Yamanashi, Y. and Baltimore, D. (1997) Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88, 205-211 (Pubitemid 28015869)
2. Carpino, N., Wisniewski, D., Strife, A., Marshak, D., Kobayashi, R., Stillman, B., and Clarkson, B. (1997) p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88, 197-204
3. Mashima, R., Hishida, Y., Tezuka, T., and Yamanashi, Y. (2009) The roles of Dok family adapters in immunoreceptor signaling. Immunol. Rev. 232, 273-285
4. Okada, K., Inoue, A., Okada, M., Murata, Y., Kakuta, S., Jigami, T., Kubo, S., Shiraishi, H., Eguchi, K., Motomura, M., Akiyama, T., Iwakura, Y., Higuchi, O., and Yamanashi, Y. (2006) The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312, 1802-1805 (Pubitemid 43962899)
5. Burden, S.J. (1998) The formation of neuromuscular synapses. Genes Dev. 12, 133-148
6. Sanes, J.R. and Lichtman, J.W. (2001) Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat. Rev. Neurosci. 2, 791-805 (Pubitemid 33674061)
7. Engel, A.G., Ohno, K., and Sine, S.M. (2003) Sleuthing molecular targets for neurological diseases at the neuromuscular junction. Nat. Rev. Neurosci. 4, 339-352 (Pubitemid 37280173)
8. Vincent, A., McConville, J., Farrugia, M.E., Bowen, J., Plested, P., Tang, T., Evoli, A., Matthews, I., Sims, G., Dalton, P., Jacobson, L., Polizzi, A., Blaes, F., Lang, B., Beeson, D., Willcox, N., Newsom-Davis, J., and Hoch, W. (2003) Antibodies in myasthenia gravis and related disorders. Ann. NY Acad. Sci. 998, 324-335 (Pubitemid 37194175)
9. DeChiara, T.M., Bowen, D.C., Valenzuela, D.M., Simmons, M.V., Poueymirou, W.T., Thomas, S., Kinetz, E., Compton, D.L., Rojas, E., Park, J.S., Smith, C., DiStefano, P.S., Glass, D.J., Burden, S.J., and Yancopoulos, G.D. (1996) The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 85, 501-512 (Pubitemid 26157189)
10. Hesser, B.A., Henschel, O., and Witzemann, V. (2006) Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK. Mol. Cell. Neurosci. 31, 470-480 (Pubitemid 43361926)
11. Kim, N. and Burden, S.J. (2008) MuSK controls where motor axons grow and form synapses. Nat. Neurosci. 11, 19-27
12. Glass, D.J., Bowen, D.C., Stitt, T.N., Radziejewski, C., Bruno, J., Ryan, T.E., Gies, D.R., Shah, S., Mattsson, K., Burden, S.J., DiStefano, P.S., Valenzuela, D.M., DeChiara, T.M., and Yancopoulos, G.D. (1996) Agrin acts via a MuSK receptor complex. Cell 85, 513-523 (Pubitemid 26157190)
13. Lin, W., Dominguez, B., Yang, J., Aryal, P., Brandon, E.P., Gage, F.H., and Lee, K.F. (2005) Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron 46, 569-579 (Pubitemid 40797382)
14. Misgeld, T., Kummer, T.T., Lichtman, J.W., and Sanes, J.R. (2005) Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter. Proc. Natl Acad. Sci. USA 102, 11088-11093 (Pubitemid 41105997)
15. Kummer, T.T., Misgeld, T., and Sanes, J.R. (2006) Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost. Curr. Opin. Neurobiol. 16, 74-82 (Pubitemid 43221856)
16. Lin, W., Burgess, R.W., Dominguez, B., Pfaff, S.L., Sanes, J.R., and Lee, K.F. (2001) Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature 410, 1057-1064 (Pubitemid 32391032)
17. Yang, X., Arber, S., William, C., Li, L., Tanabe, Y., Jessell, T.M., Birchmeier, C., and Burden, S.J. (2001) Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron 30, 399-410 (Pubitemid 32530584)
18. Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y. (2009) Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation. Sci. Signal. 2, ra7
19. Fuhrer, C., Sugiyama, J.E., Taylor, R.G., and Hall, Z.W. (1997) Association of muscle-specific kinase MuSK with the acetylcholine receptor in mammalian muscle. EMBO J. 16, 4951-4960 (Pubitemid 27348404)
20. Bergamin, E., Hallock, P.T., Burden, S.J., and Hubbard, S.R. (2010) The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol. Cell 39, 100-109
21. Hamuro, J., Higuchi, O., Okada, K., Ueno, M., Iemura, S., Natsume, T., Spearman, H., Beeson, D., and Yamanashi, Y. (2008) Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7. J. Biol. Chem. 283, 5518-5524
22. Hallock, P.T., Xu, C.F., Park, T.J., Neubert, T.A., Curran, T., and Burden, S.J. (2010) Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev. 24, 2451-2461
23. Jura, N., Zhang, X., Endres, N.F., Seeliger, M.A., Schindler, T., and Kuriyan, J. (2011) Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol. Cell 42, 9-22
24. Stamos, J., Sliwkowski, M.X., and Eigenbrot, C. (2002) Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277, 46265-46272 (Pubitemid 35417619)
25. Zhang, X., Gureasko, J., Shen, K., Cole, P.A., and Kuriyan, J. (2006) An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125, 1137-1149 (Pubitemid 43866200)
26. Chung, I., Akita, R., Vandlen, R., Toomre, D., Schlessinger, J., and Mellman, I. (2010) Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature 464, 783-787
27. Arteaga, C.L. (2011) ERBB receptors in cancer: signaling from the inside. Breast Cancer Res. 13, 304
28. Kolanus, W. (2007) Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction. Immunol. Rev. 218, 102-113
29. Bill, A., Schmitz, A., Albertoni, B., Song, J.N., Heukamp, L.C., Walrafen, D., Thorwirth, F., Verveer, P.J., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee, S., Thomas, R.K., Ullrich, R.T., Lang, T., and Famulok, M. (2010) Cytohesins are cytoplasmic ErbB receptor activators. Cell 143, 201-211
30. Beeson, D., Higuchi, O., Palace, J., Cossins, J., Spearman, H., Maxwell, S., Newsom-Davis, J., Burke, G., Fawcett, P., Motomura, M., Muller, J.S., Lochmuller, H., Slater, C., Vincent, A., and Yamanashi, Y. (2006) Dok-7 mutations underlie a neuromuscular junction synaptopathy. Science 313, 1975-1978 (Pubitemid 44498007)
31. Slater, C.R., Fawcett, P.R., Walls, T.J., Lyons, P.R., Bailey, S.J., Beeson, D., Young, C., and Gardner- Medwin, D. (2006) Pre- and post-synaptic abnormalities associated with impaired neuromuscular transmission in a group of patients with 'limb-girdle myasthenia'. Brain 129, 2061-2076 (Pubitemid 44289071)
32. Vogt, J., Morgan, N.V., Marton, T., Maxwell, S., Harrison, B.J., Beeson, D., and Maher, E.R. (2009) Germline mutation in DOK7 associated with fetal akinesia deformation sequence. J. Med. Genet. 46, 338-340
33. Selcen, D., Milone, M., Shen, X.M., Harper, C.M., Stans, A.A., Wieben, E.D., and Engel, A.G. (2008) Dok-7 myasthenia: phenotypic and molecular genetic studies in 16 patients. Ann. Neurol. 64, 71-87
34. Chan, C.B., Liu, X., He, K., Qi, Q., Jung, D.Y., Kim, J.K., and Ye, K. (2011) The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep. 12, 847-854