A comparative in vitro kinetic study of [ 14C]-eugenol and [ 14C]-methyleugenol activation and detoxification in human, mouse, and rat liver and lung fractions

Xenobiotica

Volumn 42, Issue 5, 2012, Pages 429-441

  Minet, Emmanuel F ^a   Daniela, Gentile ^b   Meredith, Clive ^a   Massey, Eian D ^a  

^a BRITISH AMERICAN TOBACCO   (United Kingdom)

^b CHARLES RIVER LABORATORIES   (United Kingdom)

Author keywords

alkenylbenzenes; bioactivation; conjugation; eugenol; Kinetics; metabolism; methyleugenol; oxidation

Indexed keywords

BENZENE DERIVATIVE; CARBON 14; CARCINOGEN; EUGENOL; METHYLEUGENOL; QUINONE DERIVATIVE; TOXIN;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DETOXIFICATION; GLUCURONIDATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KINETICS; LIVER; LIVER MICROSOME; LUNG; METABOLIC REGULATION; MOUSE; NONHUMAN; RAT;

ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EUGENOL; FEMALE; GLUCURONIDES; HUMANS; HYDROXYLATION; KINETICS; LIVER; LUNG; MALE; METABOLIC DETOXICATION, DRUG; METABOLIC NETWORKS AND PATHWAYS; MICE; MICROSOMES, LIVER; RATS; SPECIES SPECIFICITY; SUBCELLULAR FRACTIONS;

ANIMALIA; RATTUS;

EID: 84859343323     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.637582     Document Type: Article

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