메뉴 건너뛰기




Volumn 11, Issue 3, 2012, Pages 384-391

Hepatoprotective effect of the selective mineralocorticoid receptor antagonist, eplerenone against carbon tetrachloride-induced liver injury in rats

Author keywords

Eplerenone; Liver injury; Oxidative stress; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; EPLERENONE; GLUTATHIONE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE;

EID: 84859321978     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)30935-4     Document Type: Article
Times cited : (5)

References (52)
  • 1
    • 1342324062 scopus 로고    scopus 로고
    • Review of aldosterone- and angiotensin II-induced target organ damage and prevention
    • S truthers AD, MacDonald TM: Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res 2004; 61: 663-70.
    • (2004) Cardiovasc Res , vol.61 , pp. 663-670
    • Struthers, A.D.1    Macdonald, T.M.2
  • 2
    • 33747851971 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats
    • F ujisawa G, Muto S, Okada K, Kusano E, Ishibashi S. Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats. Transl Res 2006; 148: 149-56.
    • (2006) Transl Res , vol.148 , pp. 149-156
    • Fujisawa, G.1    Muto, S.2    Okada, K.3    Kusano, E.4    Ishibashi, S.5
  • 3
    • 0023266274 scopus 로고
    • High-affinity aldosterone binding in rat liver-a re-evaluation
    • Z aini A, Pearce P, Funder JW. High-affinity aldosterone binding in rat liver-a re-evaluation. Clin Exp Pharmacol Physiol 1987; 14: 39-45.
    • (1987) Clin Exp Pharmacol Physiol , vol.14 , pp. 39-45
    • Zaini, A.1    Pearce, P.2    Funder, J.W.3
  • 4
    • 34548500119 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • M arney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond) 2007; 113: 267-78.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 267-278
    • Marney, A.M.1    Brown, N.J.2
  • 6
    • 31544473557 scopus 로고    scopus 로고
    • Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation
    • I shizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y, Kanematsu Y, et al. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension 2005; 46: 1046-52.
    • (2005) Hypertension , vol.46 , pp. 1046-1052
    • Ishizawa, K.1    Izawa, Y.2    Ito, H.3    Miki, C.4    Miyata, K.5    Fujita, Y.6    Kanematsu, Y.7
  • 7
    • 0038314361 scopus 로고    scopus 로고
    • Changes in serum cytokine concentration: A morphological study of liver cirrhosis induced by common bile duct ligation in rats
    • L ee BS, Kim NJ, Jeong HY, Lee HY, Kang DY, Noh SM: Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in rats. Korean J Intern Med 2003; 18(1): 12-6.
    • (2003) Korean J Intern Med , vol.18 , Issue.1 , pp. 12-16
    • Lee, B.S.1    Kim, N.J.2    Jeong, H.Y.3    Lee, H.Y.4    Kang, D.Y.5    Noh, S.M.6
  • 10
    • 34548418525 scopus 로고    scopus 로고
    • Role of aldosterone in oxidative stress and renal injury
    • N ishiyama A, Kusaka T, Kitajima H. Role of aldosterone in oxidative stress and renal injury. Yakugaku Zasshi 2007; 127: 1331-7.
    • (2007) Yakugaku Zasshi , vol.127 , pp. 1331-1337
    • Nishiyama, A.1    Kusaka, T.2    Kitajima, H.3
  • 11
    • 33845476271 scopus 로고    scopus 로고
    • Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat
    • L i X, Meng Y, Wu P, Zhang Z, Yang X. Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat. Regul Pept 2007; 138: 15-25.
    • (2007) Regul Pept , vol.138 , pp. 15-25
    • Li, X.1    Meng, Y.2    Wu, P.3    Zhang, Z.4    Yang, X.5
  • 12
    • 33644895071 scopus 로고    scopus 로고
    • Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
    • N eves MF, Amiri F, Virdis A, Diep QN, Schiffrin EL. Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy. Can J Physiol Pharmacol 2005; 83: 999-1006.
    • (2005) Can J Physiol Pharmacol , vol.83 , pp. 999-1006
    • Neves, M.F.1    Amiri, F.2    Virdis, A.3    Diep, Q.N.4    Schiffrin, E.L.5
  • 14
    • 33750988751 scopus 로고    scopus 로고
    • Preventive and therapeutic effects of angiotensin II type 1 receptor blocker on hepatic fibrosis induced by bile duct ligation in rats
    • U eki M, Koda M, Yamamoto S, Matsunaga Y, Murawaki Y. Preventive and therapeutic effects of angiotensin II type 1 receptor blocker on hepatic fibrosis induced by bile duct ligation in rats. J Gastroenterol 2006; 41: 996-1004.
    • (2006) J Gastroenterol , vol.41 , pp. 996-1004
    • Ueki, M.1    Koda, M.2    Yamamoto, S.3    Matsunaga, Y.4    Murawaki, Y.5
  • 15
    • 49649085000 scopus 로고    scopus 로고
    • The aggravating mechanisms of aldosterone on kidney fibrosis
    • R emuzzi G, Cattaneo D, Perico N. The aggravating mechanisms of aldosterone on kidney fibrosis. J Am Soc Nephrol 2008; 19: 1459-62.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1459-1462
    • Remuzzi, G.1    Cattaneo, D.2    Perico, N.3
  • 16
    • 18644369234 scopus 로고    scopus 로고
    • Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C
    • T erui Y, Saito T, Watanabe H, Togashi H, Kawata S, Kamada Y, Sakuta S. Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C. Hepatology 2002; 36(4 Pt. 1): 1022.
    • (2002) Hepatology , vol.36 , Issue.4 PART 1 , pp. 1022
    • Terui, Y.1    Saito, T.2    Watanabe, H.3    Togashi, H.4    Kawata, S.5    Kamada, Y.6    Sakuta, S.7
  • 17
    • 7044222556 scopus 로고    scopus 로고
    • Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
    • Y okohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K, Hasegawa T, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology 2004; 40: 1222-5.
    • (2004) Hepatology , vol.40 , pp. 1222-1225
    • Yokohama, S.1    Yoneda, M.2    Haneda, M.3    Okamoto, S.4    Okada, M.5    Aso, K.6    Hasegawa, T.7
  • 18
    • 70350511929 scopus 로고    scopus 로고
    • Effect of an angiotensin-II type-1 receptor blocker, candesartan on hepatic fibrosis in chronic hepatitis C: A prospective study
    • U eki M, Koda M, Shimizu T, Mitsuta A, Yamamoto T, Murawaki Y. Effect of an angiotensin-II type-1 receptor blocker, candesartan on hepatic fibrosis in chronic hepatitis C: a prospective study. Hepatogastroenterology 2009; 56: 1100-4.
    • (2009) Hepatogastroenterology , vol.56 , pp. 1100-1104
    • Ueki, M.1    Koda, M.2    Shimizu, T.3    Mitsuta, A.4    Yamamoto, T.5    Murawaki, Y.6
  • 19
    • 0031017601 scopus 로고    scopus 로고
    • Prevention of portal hypertension by propranolol and spironolactone in rats with bile duct ligation
    • O berti F, Rifflet H, Maiga MY, Pilette C, Gallois Y, Douay O, et al. Prevention of portal hypertension by propranolol and spironolactone in rats with bile duct ligation. J Hepatol 1997; 26: 167-73.
    • (1997) J Hepatol , vol.26 , pp. 167-173
    • Oberti, F.1    Rifflet, H.2    Maiga, M.Y.3    Pilette, C.4    Gallois, Y.5    Douay, O.6
  • 20
    • 0030825512 scopus 로고    scopus 로고
    • Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation
    • O berti F, Pilette C, Rifflet H, Maiga MY, Moreau A, Gallois Y, Girault A, et al. Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation. J Hepatol 1997; 26: 1363-71.
    • (1997) J Hepatol , vol.26 , pp. 1363-1371
    • Oberti, F.1    Pilette, C.2    Rifflet, H.3    Maiga, M.Y.4    Moreau, A.5    Gallois, Y.6    Girault, A.7
  • 21
    • 0037861923 scopus 로고    scopus 로고
    • Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension
    • W hite WB, Carr AA, Krause S, Jordan R, Roniker B, Oigman W. Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension. Am J Cardiol 2003; 92: 38-42.
    • (2003) Am J Cardiol , vol.92 , pp. 38-42
    • White, W.B.1    Carr, A.A.2    Krause, S.3    Jordan, R.4    Roniker, B.5    Oigman, W.6
  • 24
    • 36849077592 scopus 로고    scopus 로고
    • Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure
    • R astogi S, Mishra S, Zaca V, Alesh I, Gupta RC, Goldstein S, Sabbah HN. Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure. Cardiovasc Drugs Ther 2007; 21: 415-22.
    • (2007) Cardiovasc Drugs Ther , vol.21 , pp. 415-422
    • Rastogi, S.1    Mishra, S.2    Zaca, V.3    Alesh, I.4    Gupta, R.C.5    Goldstein, S.6    Sabbah, H.N.7
  • 25
    • 34249794560 scopus 로고    scopus 로고
    • Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: Involvement of tenascin-C induced by aldosterone-mediated inflammation
    • N ishioka T, Suzuki M, Onishi K, Takakura N, Inada H, Yoshida T, Hiroe M, et al. Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation. J Cardiovasc Pharmacol 2007; 49: 261-8.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 261-268
    • Nishioka, T.1    Suzuki, M.2    Onishi, K.3    Takakura, N.4    Inada, H.5    Yoshida, T.6    Hiroe, M.7
  • 26
    • 0345103741 scopus 로고    scopus 로고
    • Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor- mediated pro-apoptotic signaling
    • W eber T, Dalen H, Andera L, Negre-Salvayre A, Auge N, Sticha M, Lloret A, et al. Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor- mediated pro-apoptotic signaling. Biochemistry 2003; 42: 4277-91.
    • (2003) Biochemistry , vol.42 , pp. 4277-4291
    • Weber, T.1    Dalen, H.2    Andera, L.3    Negre-Salvayre, A.4    Auge, N.5    Sticha, M.6    Lloret, A.7
  • 27
    • 77952763556 scopus 로고    scopus 로고
    • The effects of the selective mineralocorticoid receptor antagonist eplerenone on hepatic fibrosis induced by bile duct ligation in rat
    • M atono T, Koda M, Tokunaga S, Sugihara T, Ueki M, Murawaki Y. The effects of the selective mineralocorticoid receptor antagonist eplerenone on hepatic fibrosis induced by bile duct ligation in rat. Int J Mol Med 2010; 25: 875-82.
    • (2010) Int J Mol Med , vol.25 , pp. 875-882
    • Matono, T.1    Koda, M.2    Tokunaga, S.3    Sugihara, T.4    Ueki, M.5    Murawaki, Y.6
  • 28
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • R eitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28: 56-63.
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 29
    • 0017749901 scopus 로고
    • Plasma alkaline phosphatase assay: Interconversion of results by two methods
    • E aton RH. Plasma alkaline phosphatase assay: interconversion of results by two methods. Clin Chem 1977; 23: 2148-50.
    • (1977) Clin Chem , vol.23 , pp. 2148-2150
    • Eaton, R.H.1
  • 30
    • 0014394115 scopus 로고
    • Critical analysis of bilirubinemia and diagnostic value of direct bilirubin determination by the Malloy-Evelyn method
    • M erino RA, Lalive J, Parga GL. Critical analysis of bilirubinemia and diagnostic value of direct bilirubin determination by the Malloy-Evelyn method. Rev Med Chil 1968; 96: 794-8.
    • (1968) Rev Med Chil , vol.96 , pp. 794-798
    • Merino, R.A.1    Lalive, J.2    Parga, G.L.3
  • 31
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • B uege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-10.
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 32
    • 67650519656 scopus 로고    scopus 로고
    • Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats
    • E l-Sherbiny GA, Taye A, Abdel-Raheem IT. Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats. Ann Hepatol 2009; 8: 134-40.
    • (2009) Ann Hepatol , vol.8 , pp. 134-140
    • El-Sherbiny, G.A.1    Taye, A.2    Abdel-Raheem, I.T.3
  • 34
    • 33947142911 scopus 로고    scopus 로고
    • Cystic degeneration in liver injury induced by CCl4 in SD rats
    • X u Q, Shen YP, Xu AL. Cystic degeneration in liver injury induced by CCl4 in SD rats. Zhongguo Zhong Yao Za Zhi 2006; 31: 1880-1.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , pp. 1880-1881
    • Xu, Q.1    Shen, Y.P.2    Xu, A.L.3
  • 35
    • 33845892762 scopus 로고    scopus 로고
    • Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells
    • D i Sario A, Bendia E, Omenetti A, De Minicis S, Marzioni M, Kleemann HW, Candelaresi C, et al. Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells. Dig Liver Dis 2007; 39: 60-9.
    • (2007) Dig Liver Dis , vol.39 , pp. 60-69
    • di Sario, A.1    Bendia, E.2    Omenetti, A.3    de Minicis, S.4    Marzioni, M.5    Kleemann, H.W.6    Candelaresi, C.7
  • 36
  • 37
    • 0032795382 scopus 로고    scopus 로고
    • Metabolism of carbon tetrachloride to trichloromethyl radical: An ESR and HPLC-EC study
    • S toyanovsky DA, Cederbaum AI. Metabolism of carbon tetrachloride to trichloromethyl radical: An ESR and HPLC-EC study. Chem Res Toxicol 1999; 12: 730-6.
    • (1999) Chem Res Toxicol , vol.12 , pp. 730-736
    • Stoyanovsky, D.A.1    Cederbaum, A.I.2
  • 38
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • L i X, Liu Y, Song L, Liu J. Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 2003; 42: 85-9.
    • (2003) Toxicon , vol.42 , pp. 85-89
    • Li, X.1    Liu, Y.2    Song, L.3    Liu, J.4
  • 39
    • 0031234404 scopus 로고    scopus 로고
    • Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats
    • A lptekin N, Mehmetcik G, Uysal M, Aykac-toker G. Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats. Pharmacol Res 1997; 36 (3): 243-7.
    • (1997) Pharmacol Res , vol.36 , Issue.3 , pp. 243-247
    • Alptekin, N.1    Mehmetcik, G.2    Uysal, M.3    Aykac-Toker, G.4
  • 40
    • 34548066660 scopus 로고    scopus 로고
    • Aldosterone stimulating PDGF-B expression in HSC via activation of EGR-1. Z
    • Li X, Meng Y, Yang XS, Wu PS, Zhang ZS. Aldosterone stimulating PDGF-B expression in HSC via activation of EGR-1. Z honghua Gan Zang Bing Za Zhi 2005; 13: 567-70.
    • (2005) Honghua Gan Zang Bing Za Zhi , vol.13 , pp. 567-570
    • Li, X.1    Meng, Y.2    Yang, X.S.3    Wu, P.S.4    Zhang, Z.S.5
  • 42
    • 60549093928 scopus 로고    scopus 로고
    • Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat
    • P ark YM, Lim BH, Touyz RM, Park JB. Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat. J Korean Med Sci 2008; 23: 1039-45.
    • (2008) J Korean Med Sci , vol.23 , pp. 1039-1045
    • Park, Y.M.1    Lim, B.H.2    Touyz, R.M.3    Park, J.B.4
  • 44
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • P itt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7
  • 45
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • P itt B, Reichek N, Willenbrock R, Zannad F, Phillips RA, Roniker B, Kleiman J, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108: 1831-8.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3    Zannad, F.4    Phillips, R.A.5    Roniker, B.6    Kleiman, J.7
  • 46
    • 44049097881 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    • G uo C, Ricchiuti V, Lian BQ, Yao TM, Coutinho P, Romero JR, et al. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation 2008; 117: 2253-61.
    • (2008) Circulation , vol.117 , pp. 2253-2261
    • Guo, C.1    Ricchiuti, V.2    Lian, B.Q.3    Yao, T.M.4    Coutinho, P.5    Romero, J.R.6
  • 47
    • 77957753743 scopus 로고    scopus 로고
    • Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats
    • J aggi AS, Singh N. Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. Eur J Pharmacol 2010; 648: 102-9.
    • (2010) Eur J Pharmacol , vol.648 , pp. 102-109
    • Jaggi, A.S.1    Singh, N.2
  • 48
    • 0037305678 scopus 로고    scopus 로고
    • Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats
    • F rancis J, Weiss RM, Johnson AK, Felder RB. Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. Am J Physiol Regul Integr Comp Physiol 2003; 284: R328-R335.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Francis, J.1    Weiss, R.M.2    Johnson, A.K.3    Felder, R.B.4
  • 49
    • 84859320192 scopus 로고    scopus 로고
    • The stress response and immune function: Clinical implications. The 1999 Novera H. Spector Lecture
    • C hrousos GP. The stress response and immune function: clinical implications. The 1999 Novera H. Spector Lecture. Ann N Y Acad Sci 2000; 38: 917-67.
    • (2000) Ann N Y Acad Sci , vol.38 , pp. 917-967
    • Chrousos, G.P.1
  • 50
    • 0037035471 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism in experimental atherosclerosis
    • R ajagopalan S, Duquaine D, King S, Pitt B, Patel P. Mineralocorticoid receptor antagonism in experimental atherosclerosis. Circulation 2002; 105: 2212-6.
    • (2002) Circulation , vol.105 , pp. 2212-2216
    • Rajagopalan, S.1    Duquaine, D.2    King, S.3    Pitt, B.4    Patel, P.5
  • 52
    • 33646692656 scopus 로고    scopus 로고
    • Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation
    • S uzuki J, Iwai M, Mogi M, Oshita A, Yoshii T, Higaki J, Horiuchi M. Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation. Arterioscler Thromb Vasc Biol 2006; 26: 917-21.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 917-921
    • Suzuki, J.1    Iwai, M.2    Mogi, M.3    Oshita, A.4    Yoshii, T.5    Higaki, J.6    Horiuchi, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.