Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness

Journal of Proteomics

Volumn 75, Issue 8, 2012, Pages 2442-2453

  Fahmi, Laila ^a   Makran, Bouchra ^a   Pla, Davinia ^b   Sanz, Libia ^b   Oukkache, Naoual ^a   Lkhider, Mustapha ^c   Harrison, Robert A ^d   Ghalim, Noreddine ^a   Calvete, Juan J ^b,e  

^a Institut Pasteur du Maroc   (Morocco)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c FACULTÉ DES SCIENCES   (Morocco)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Antivenomics; Ceraste vipera; Cerastes cerastes; Mass spectrometry; Snake venomics; Venom proteome

Indexed keywords

HEMOSTATIC AGENT; PROTEOME; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ARTICLE; CERASTES CERASTES; CROSS REACTION; EGYPT; IMMUNOREACTIVITY; MOROCCO; NONHUMAN; NORTH AFRICA; PRIORITY JOURNAL; PROTEOMICS; SNAKE; TUNISIA;

AFRICA, NORTHERN; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; ANTIVENINS; CHROMATOGRAPHY, AFFINITY; GEOGRAPHY; METABOLOME; POPULATION; PROTEOME; SPECIES SPECIFICITY; TREATMENT FAILURE; VIPER VENOMS; VIPERIDAE;

CERASTES; CERASTES CERASTES; CERASTES VIPERA; VIPERA;

EID: 84859268403     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.02.021     Document Type: Article

References (44)

1. Phelps T. Old World Vipers. A Natural History of the Azemiopinae, and Viperinae. Edition Chimaira 2010.
2. WHO Regional Office for Africa Guidelines for the Prevention and Clinical Management of Snakebite in Africa, Brazzaville 2010.
3. Mallow D., Ludwig D., Nilson G. True Vipers: Natural History and Toxinology of Old World Vipers 2003, Krieger Publishing Company, 359pp.
4. Geniez P., Ineich I., Ben Kirane C., Bons J. Les serpents venimeux du Maroc: Position systématique et état des connaissances sur leur distribution. Actes Inst Agronom Vet Hassan II 1992, 12:37-48.
5. Spawls S, Branch B. The Dangerous Snakes of Africa. Ralph Curtis Books. Dubai: Oriental Press, 1995, 192 pp. ISBN 0-88359-029-8.
6. Schneemann M., Cathomas R., Laidlaw S.T., El Nahas A.M., Theakston R.D.G., Warrell D.A. Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, coagulopathy and acute renal failure: clinical cases and review. Q J Med 2004, 97:717-727.
7. Ben-Baruch N., Porath A., Kleiner-Baumgarten A., Keynan A. Cerastes vipera envenoming-a report of seven cases. Trans R Soc Trop Med Hyg 1986, 80:664.
8. Lifshitz M., Kapelushnik J., Ben-Harosh M., Sofer S. Disseminated intravascular coagulation after Cerastes vipera envenomation in a 3-year-old child: a case report. Toxicon 2000, 38:1593-1598.
9. Lifshitz M.P., Bernstein T., Sofer S. Snake bite by Cerastes vipera in children: report of two cases. Wilderness Environ Med 1995, 6:269-272.
10. Chippaux J.-P., Williams V., White J. Snake venom variability: methods of study, results and interpretation. Toxicon 1991, 29:1279-1303.
11. Raw I., Guidolin R., Higashi H.G., Kelen E.M.A. Antivenins in Brazil: Preparation. Handbook of Natural Toxins 1991, 557-811. Marcel Dekker, New York. A. Tu (Ed.).
12. Practical Handbook of Biochemistry and Molecular Biology 1992, CRC Press, Boston. D.G. Fasman (Ed.).
13. Calvete J.J., Juárez P., Sanz L. Snake venomics. Strategy and applications. J Mass Spectrom 2007, 42:1405-1414.
14. Bazaa A., Marrakchi N., El Ayeb M., Sanz L., Calvete J.J. Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina. Proteomics 2005, 5:4223-4235.
15. Calvete J.J., Sanz L., Angulo Y., Lomonte B., Gutiérrez J.M. Venoms, venomics, antivenomics. FEBS Lett 2009, 583:1736-1743.
16. Kochva E. Venomous snakes of Israel: ecology and snake bite. Public Health Rev 1998, 26:209-232.
17. Chani M., L'kassimi H., Abouzahir A., Nazi M., Mion G. Three case-reports of viperin envenoming in Morocco. Ann Fr Anesth Reanim 2008, 27:330-334.
18. Shulzinska H., Keynan A., Dvilansky A. Effect of Cerastes cerastes snake bite on coagulation. Harefuah 1978, 94:323-324.
19. Lifshitz M., Kastel H., Harman-Boehm I. Cerastes cerastes envenomation in an 18 year old female: a case report. Toxicon 2002, 40:1227-1229.
20. Valenta J., Stach Z., Svítek M. Acute pancreatitis after viperid snake cerastes cerastes envenoming: a case report. Prague Med Rep 2010, 111:69-75.
21. Sajevic A., Leonardi A., Križaj I. Haemostatically active proteins in snake venoms. Toxicon 2011, 57:627-645.
22. Markland F.S. Snake venom proteins acting on hemostasis. Toxicon 1998, 36:1749-1800.
23. Gutiérrez J.M., Rucavado A., Escalante T., Díaz C. Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. Toxicon 2005, 45:997-1011.
24. Fox J.W., Serrano S.M. Timeline of key events in snake venom metalloproteinase research. J Proteomics 2009, 72:200-209.
25. Gasmi A., Srairi A., Karoui H., El Ayeb M. Amino acid sequence of VlF: identification in the C-terminal domain of residues common to non-hemorrhagic metalloproteinases from snake venoms. Biochim Biophys Acta 2000, 1481:209-212.
26. Patiño A.C., Pereañez J.A., Núñez V., Benjumea D.M., Fernandez M., Rucavado A., et al. Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom. Toxicon 2010, 56:936-943.
27. Kini R., Evans H.J. Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor. Toxicon 1992, 30:265-293.
28. Okuda D., Koike H., Morita T. A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region. Biochemistry 2002, 41:14248-14254.
29. Calvete J.J. Brief history and molecular determinants of snake venom disintegrin evolution. Toxins and Hemostasis: from Bench to Bedside 2010, 285-300. Springer, Amsterdam, Chapter 18. R.M. Kini, F. Markland, M.A. McLane, T. Morita (Eds.).
30. 1 integrins. Biochemistry 2002, 41:2014-2021.
31. Clemetson K.J., Lu Q., Clemetson J.M. Snake C-type lectin-like proteins and platelet receptors. Pathophysiol Haemost Thromb 2005, 34:150-155.
32. Morita T. Structure-function relationships of C-type lectin-related proteins. Pathophysiol Haemost Thromb 2005, 34:156-159.
33. 2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett 2009, 16:860-876.
34. 2: insights into the mechanisms of local and systemic myotoxicity. Toxicon 2003, 42:915-931.
35. Du X.-D., Clemetson K.J. Snake venom L-amino acid oxidases. Toxicon 2002, 40:659-665.
36. Fernández J., Lomonte B., Sanz L., Angulo Y., Gutiérrez J.M., Calvete J.J. Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose. J Proteome Res 2010, 9:4234-4241.
37. Gutiérrez J.M., Sanz L., Flores-Díaz M., Figueroa L., Madrigal M., Herrera M., et al. Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches. J Proteome Res 2010, 9:564-577.
38. Williams D.J., Gutiérrez J.M., Calvete J.J., Wüster W., Ratanabanangkoon K., Paiva O., et al. Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. J Proteomics 2011, 74:1735-1767.
39. Gutiérrez J.M., Lomonte B., León G., Alape-Girón A., Flores-Díaz M., Sanz L., et al. Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming. J Proteomics 2009, 72:165-182.
40. Lomonte B., Escolano J., Fernández J., Sanz L., Angulo Y., Gutiérrez J.M., et al. Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii. J Proteome Res 2008, 7:2445-2457.
41. Fry B.G., Wickramaratna J.C., Jones A., Alewood P.F., Hodgson W.C. Species and regional variations in the effectiveness of antivenom against the in vitro neurotoxicity of death adder (Acanthophis) venoms. Toxicol Appl Pharmacol 2001, 175:140-148.
42. Judge R.K., Henry P.J., Mirtschin P., Jelinek G., Wilce J.A. Toxins not neutralized by brown snake antivenom. Toxicol Appl Pharmacol 2006, 213:117-125.
43. Gutiérrez J.M., Sanz L., Escolano J., Fernández J., Lomonte B., Angulo Y., et al. Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom. J Proteome Res 2008, 7:4396-4408.
44. Antúnez J., Fernández J., Lomonte B., Angulo Y., Sanz L., Pérez A., et al. Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities. J. Venom Res 2010, 1:8-17.