Toxins not neutralized by brown snake antivenom

Toxicology and Applied Pharmacology

Volumn 213, Issue 2, 2006, Pages 117-125

  Judge, Roopwant K ^a   Henry, Peter J ^b   Mirtschin, Peter ^c   Jelinek, George ^d   Wilce, Jacqueline A ^e  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c Venom Supplies   (Australia)

^d School of Primary   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Antivenom; Brown snake venom; Neurotoxin; Organ bath; Phospholipase A2; Western blot

Indexed keywords

CARBACHOL; COAGULATING AGENT; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; SNAKE VENOM; SNAKE VENOM ANTISERUM; PHOSPHOLIPASE A; REPTILIAN PROTEIN; VENOM ANTISERUM;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; IMMUNOBLOTTING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; MUSCLE CONTRACTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DETERMINATION; RAT; SEQUENCE ANALYSIS; SNAKE; SPECIES COMPARISON; TOXIN ANALYSIS; TRACHEA; TWO DIMENSIONAL ELECTROPHORESIS; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; IMMUNOLOGY; ORGAN CULTURE TECHNIQUE; PROTEIN BINDING; PROTEOMICS; SERODIAGNOSIS; SPECIES DIFFERENCE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

PSEUDONAJA; PSEUDONAJA AFFINIS; PSEUDONAJA NUCHALIS; PSEUDONAJA TEXTILIS; SERPENTES; STORERIA DEKAYI;

ANIMALS; ANTIVENINS; ELAPID VENOMS; ELAPIDAE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; IMMUNOBLOTTING; MOLECULAR WEIGHT; MUSCLE CONTRACTION; NEUTRALIZATION TESTS; ORGAN CULTURE TECHNIQUES; PHOSPHOLIPASES A; PROTEIN BINDING; PROTEOMICS; RATS; REPTILIAN PROTEINS; SPECIES SPECIFICITY; TRACHEA;

EID: 33745955365     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.09.010     Document Type: Article

References (43)

1. Altschul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215 (1990) 403-410
2. 2 from Pseudonaja textilis. Arch. Biochem. Biophys. 421 (2004) 10-20
3. Chippaux J.P. Snake-bites: appraisal of the global situation. Bull. World Health Organ. 76 (1998) 515-524
4. Cogger H. Reptiles and Amphibians of Australia (1975), Reed Pty Ltd., London 7-25
5. Filippovich I., Sorokina N., Masci P.P., de Jersey J., Whitaker A.N., Winzor D.J., Gaffney P.J., and Lavin M.F. A family of textilinin genes, two of which encode proteins with antihaemorrhagic properties. Br. J. Haematol. 119 (2002) 376-384
6. Francis B., Coffield J.A., Simpson L.L., and Kaiser II. New toxins from the venom of the common tiger snake (Notechis scutatus scutatus). Arch. Biochem. Biophys. 318 (1995) 481-488
7. Fry B.G., Wickramaratna J.C., Jones A., Alewood P.F., and Hodgson W.C. Species and regional variations in the effectiveness of antivenom against the in vitro neurotoxicity of death adder (Acanthophis) venoms. Toxicol. Appl. Pharmacol. 175 (2001) 140-148
8. Gong N., Armugam A., and Jeyaseelan K. Postsynaptic short-chain neurotoxins from Pseudonaja textilis. cDNA cloning, expression and protein characterization. Eur. J. Biochem. 265 (1999) 982-989
9. Grieg Fry B. Structure-function properties of venom components from Australian elapids. Toxicon 37 (1998) 11-32
10. Harris J.B. Snake Venoms: International Encyclopedia of Pharmacology and Therapeutics Section 134 (1991), Pergamon Press, New York 91-129
11. Henderson A., Baldwin L.N., and May C. Fatal brown snake (Pseudonaja textilis) envenomation despite the use of antivenom. Med. J. Aust. 158 (1993) 709-710
12. Jelinek G.A., and Breheny F.X. Ten years of snakebite at Fremantle Hospital. Med. J. Aust. 153 (1990) 658-661
13. Jelinek G.A., Hamilton T., and Hirsch R.L. Admissions for suspected snake bite to the Perth adult teaching hospitals, 1979 to 1988. Med. J. Aust. 155 (1991) 761-764
14. Joseph J.S., Chung M.C., Jeyaseelan K., and Kini R.M. Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa. Blood 94 (1999) 621-631
15. Judge R.K., Henry P.J., d'Aprile A.C., Lynch D., Jelinek G.A., Wilce M.C., and Wilce J.A. Identification of PLA(2) and alpha-neurotoxin proteins in the venom of Pseudonaja affinis (dugite). Toxicol. Appl. Pharmacol. 181 (2002) 184-191
16. 2 Enzymes: Structure, Function and Mechanism (1997), John Wiley and Sons, Chichester, UK 1-28
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
18. Li S., Wang J., Zhang X., Ren Y., Wang N., Zhao K., Chen X., Zhao C., Li X., Shao J., Yin J., West M.B., Xu N., and Liu S. Proteomic characterization of two snake venoms: Naja naja atra and Agkistrodon halys. Biochem. J. 384 (2004) 119-127
19. Marshall L.R., and Herrmann R.P. Coagulant and anticoagulant actions of Australian snake venoms. Thromb. Haemost. 50 (1983) 707-711
20. Masci P.P., Mirtschin P.J., Nias T.N., Turnbull R.K., Kuchel T.R., and Whitaker A.N. Brown snakes (Pseudonaja genus): venom yields, prothrombin activator neutralization and implications affecting antivenom usage. Anaesth. Intensive Care 26 (1998) 276-281
21. Masci P.P., Whitaker A.N., Sparrow L.G., de Jersey J., Winzor D.J., Watters D.J., Lavin M.F., and Gaffney P.J. Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model. Blood Coagul. Fibrinolysis 4 (2000) 385-393
22. Nicholson G.M., Spence I., Lloyd D.R., Wilson H., Harrison B.M., Tyler M., and Howden M.E.H. Presynaptic actions of textilotoxin, a neurotoxin from the Australian common brown snake (Pseudonaja textilis). 10th World Congress on Animal, Plant and Microbial Toxins, Singapore (1992) 540-548
23. Oshima-Franco Y., Hyslop S., Prado-Franceschi J., Cruz-Hofling M.A., and Rodrigues-Simioni L. Neutralizing capacity of antisera raised in horses and rabbits against Crotalus durissus terrificus (South American rattlesnake) venom and its main toxin, crotoxin. Toxicon 37 (1999) 1341-1357
24. 2 from Agkistrodon halys pallas venom and it's expression in E. coli. Toxicon 36 (1998) 1155-1163
25. Pearson J.A., Tyler M.I., Retson K.V., and Howden M.E. Studies on the subunit structure of textilotoxin, a potent presynaptic neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis): 2. The amino acid sequence and toxicity studies of subunit D. Biochim. Biophys. Acta 1077 (1991) 147-150
26. Pearson J.A., Tyler M.I., Retson K.V., and Howden M.E. Studies on the subunit structure of textilotoxin, a potent presynaptic neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis): 3. The complete amino-acid sequences of all the subunits. Biochim. Biophys. Acta 1161 (1993) 223-229
27. Poorafshar M., Aveskogh M., Munday B., and Hellman L. Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus. Immunogenetics 52 (2000) 19-28
28. Prieto da Silva A.R., Yamagushi I.K., Morais J.F., Higashi H.G., Raw I., Ho P.L., and Oliveira J.S. Cross reactivity of different specific Micrurus antivenom sera with homologous and heterologous snake venoms. Toxicon 39 (2001) 949-953
29. Rao V.S., and Kini R.M. Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. Thromb. Haemost. 88 (2002) 611-619
30. Saravia P., Rojas E., Escalante T., Arce V., Chaves E., Velasquez R., Lomonte B., Rojas G., and Gutierrez J.M. The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms. Toxicon 39 (2001) 401-405
31. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., and Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150 (1985) 76-85
32. Sprivulis P., Jelinek G.A., and Marshall L.M. Efficacy and potency of antivenoms in neutralizing the procoagulant effects of Australian snake venoms in dog and human plasma. Anaesth. Intensive Care 24 (1996) 379-381
33. Stewart C.J. Snake bite in Australia: first aid and envenomation management. Accid. Emerg. Nurs. 11 (2003) 106-111
34. Stocker K., Hauer H., Muller C., and Triplett D.A. Isolation and characterization of textarin, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom. Toxicon 32 (1994) 1227-1236
35. Sutherland S.K. Deaths from snakebite in Australia. Med. J. Aust. 157 (1992) 740-746
36. Sutherland S.K., and Tibballs J. Australian Animal Toxins (2001), Oxford Univ. Press, London 30-50
37. Tibballs J., Sutherland S.K., and Kerr S. Studies on Australian snake venoms: Part II. The haematological effects of brown snake (Pseudonaja) species in the dog. Anaesth. Intensive Care 19 (1991) 338-342
38. Tyler M.I., Barnett D., Nicholson P., Spence I., and Howden M.E. Studies on the subunit structure of textilotoxin, a potent neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis). Biochim. Biophys. Acta 915 (1987) 210-216
39. White J. Elapid Snakes: Aspects of Envenomation (1987), Queensland Museum Press, Brisbane, Australia 8-17
40. White J. Envenoming and antivenom use in Australia. Toxicon 36 (1998) 1483-1492
41. WHO/SEARO. WHO/SEARO guidelines for the clinical management of snake bites in the Southeast Asian region. Southeast Asian J. Trop. Med. Public Health 30 (1999) 1-85
42. Williams V., White J., and Mirtschin P.J. Comparative study on the procoagulant from the venom of Australian brown snakes (Elapidae; Pseudonaja spp.). Toxicon 32 (1994) 453-459
43. Yeung J.M., Little M., Murray L., Jelinek G.A., and Daly F.F.S. Antivenom dosing in 35 patients with severe brown snake (Pseudonaja) envenoming in Western Australia over 10 years. Med. J. Aust. 181 (2004) 703-706