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Volumn 7, Issue 1, 2012, Pages 3-12

Can prognostic factors be used to direct therapy in chronic lymphocytic Leukemia?

Author keywords

11q deletion; 17p deletion; Allogeneic; Chronic lymphocytic leukemia; CLL; Consolidation; Early treatment; IGHV.MRD; Maintenance; Predictive factors; TP53

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; FLAVOPIRIDOL; FLUDARABINE; IMMUNOGLOBULIN HEAVY CHAIN; LENALIDOMIDE; OFATUMUMAB; PREDNISOLONE; PROTEIN P53; RITUXIMAB; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 84859259807     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-011-0110-1     Document Type: Review
Times cited : (12)

References (76)
  • 2
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood. 2008;112(4):975-80.
    • (2008) Blood , vol.112 , Issue.4 , pp. 975-980
    • Tam, C.S.1    O'brien, S.2    Wierda, W.3
  • 3
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • This work presents the effect of the addition of rituximab to FC on response, PFS, and OS in a large, prospective clinical trial. Additionally, response and outcome are demonstrated according to different prognostic parameters
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-74. This work presents the effect of the addition of rituximab to FC on response, PFS, and OS in a large, prospective clinical trial. Additionally, response and outcome are demonstrated according to different prognostic parameters.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 4
    • 77949446259 scopus 로고    scopus 로고
    • Allotransplantation for chronic lymphocytic leukemia
    • Dreger P. Allotransplantation for chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2009:602-609.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 602-609
    • Dreger, P.1
  • 5
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A reportfrom the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a reportfrom the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-56.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 6
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-34.
    • (1975) Blood , vol.46 , Issue.2 , pp. 219-234
    • Rai, K.R.1    Sawitsky, A.2    Cronkite, E.P.3
  • 7
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • DOI 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0. CO;2-V
    • Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206. (Pubitemid 11064396)
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 8
    • 78649455942 scopus 로고    scopus 로고
    • Prognosis of Binet stage A chronic lymphocytic leukemia patients: The strength of routine parameters
    • Letestu R, Levy V, Eclache V, et al. Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters. Blood. 2010;116(22):4588-90.
    • (2010) Blood , vol.116 , Issue.22 , pp. 4588-4590
    • Letestu, R.1    Levy, V.2    Eclache, V.3
  • 9
    • 85027920745 scopus 로고    scopus 로고
    • Prognostic factors in chronic lymphocytic leukemia-what do we need to know?
    • Cramer P, Hallek M. Prognostic factors in chronic lymphocytic leukemia-what do we need to know? Nat Rev Clin Oncol. 2011;8 (1):38-47.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.1 , pp. 38-47
    • Cramer, P.1    Hallek, M.2
  • 12
    • 73649116987 scopus 로고    scopus 로고
    • The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
    • Klein U, Lia M, Crespo M, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell. 2010;17(1):28-40.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 28-40
    • Klein, U.1    Lia, M.2    Crespo, M.3
  • 13
    • 79952453663 scopus 로고    scopus 로고
    • 13q deletion anatomy and disease progression in patients with chronic lymphocyticleukemia
    • Parker H, Rose-Zerilli MJ, Parker A, et al. 13q deletion anatomy and disease progression in patients with chronic lymphocyticleukemia. Leukemia. 2011;25(3):489-97.
    • (2011) Leukemia , vol.25 , Issue.3 , pp. 489-497
    • Parker, H.1    Rose-Zerilli, M.J.2    Parker, A.3
  • 15
    • 0022646788 scopus 로고
    • Localization of gene for human p53 tumour antigen to band 17p13
    • Isobe M, Emanuel BS, Givol D, et al. Localization of gene forhuman p53 tumour antigen to band 17p13. Nature. 1986;320 (6057):84-5. (Pubitemid 16105254)
    • (1986) Nature , vol.320 , Issue.6057 , pp. 84-85
    • Isobe, M.1    Emanuel, B.S.2    Givol, D.3
  • 16
    • 79953187897 scopus 로고    scopus 로고
    • Importance of genetics in chronic lymphocytic leukemia
    • Zenz T, Mertens D, Dohner H, Stilgenbauer S. Importance of genetics in chronic lymphocytic leukemia. Blood Rev. 2011;25(3):131-7.
    • (2011) Blood Rev , vol.25 , Issue.3 , pp. 131-137
    • Zenz, T.1    Mertens, D.2    Dohner, H.3    Stilgenbauer, S.4
  • 17
    • 79551504914 scopus 로고    scopus 로고
    • TP53 mutation and survival in chronic lymphocytic leukemia
    • This work analyses the response and survival of CLL patients with TP53 mutations after fludarabine-basedchemotherapy
    • Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol. 2010;28(29):4473-9. This work analyses the response and survival of CLL patients with TP53 mutations after fludarabine-basedchemotherapy.
    • (2010) J Clin Oncol , vol.28 , Issue.29 , pp. 4473-4479
    • Zenz, T.1    Eichhorst, B.2    Busch, R.3
  • 18
    • 0036096157 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
    • Stankovic T, Stewart GS, Fegan C, et al. Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood. 2002;99(1):300-9.
    • (2002) Blood , vol.99 , Issue.1 , pp. 300-309
    • Stankovic, T.1    Stewart, G.S.2    Fegan, C.3
  • 19
    • 0035437138 scopus 로고    scopus 로고
    • P53 dysfunction in Bcell chronic lymphocytic leukemia: Inactivation of ATM as an alternative to TP53 mutation
    • Pettitt AR, Sherrington PD, Stewart G, et al. p53 dysfunction in Bcell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood. 2001;98(3):814-22.
    • (2001) Blood , vol.98 , Issue.3 , pp. 814-822
    • Pettitt, A.R.1    Sherrington, P.D.2    Stewart, G.3
  • 21
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • In this work, new recurrent mutations in CLL were identified with next-generation sequencing
    • Puente XS, PinyolM, Quesada V, et al.Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.Nature. 2011;475(7354):101-5. In this work, new recurrent mutations in CLL were identified with next-generation sequencing.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 101-105
    • Puente, X.S.1    Lm, P.2    Quesada, V.3
  • 22
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med. 2011;208(7):1389-401.
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3
  • 23
    • 84857995424 scopus 로고    scopus 로고
    • SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
    • Visconte V, Makishima H, Jankowska A, et al. SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts. Leukemia. 2011.
    • (2011) Leukemia
    • Visconte, V.1    Makishima, H.2    Jankowska, A.3
  • 24
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478 (7367):64-9.
    • (2011) Nature , vol.478 , Issue.7367 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 25
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association withprogression and fludarabine-refractoriness
    • Rossi D, Bruscaggin A, Spina V, et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association withprogression and fludarabine-refractoriness. Blood. 2011.
    • (2011) Blood
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3
  • 26
    • 72949093335 scopus 로고    scopus 로고
    • From pathogenesis to treatment of chronic lymphocytic leukaemia
    • Zenz T, Mertens D, Kuppers R, et al. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer. 2010;10(1):37-50.
    • (2010) Nat Rev Cancer , vol.10 , Issue.1 , pp. 37-50
    • Zenz, T.1    Mertens, D.2    Kuppers, R.3
  • 28
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocyticleukemia. Blood. 1999;94(6):1848-54. (Pubitemid 29430400)
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 30
    • 33645507226 scopus 로고    scopus 로고
    • Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent ofgeographic origin and mutational status
    • Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent ofgeographic origin and mutational status. Blood. 2006;107 (7):2889-94.
    • (2006) Blood , vol.107 , Issue.7 , pp. 2889-2894
    • Thorselius, M.1    Krober, A.2    Murray, F.3
  • 31
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • DOI 10.1182/blood-2002-06-1683
    • Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 isassociated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2002;100(13):4609-14. (Pubitemid 35429705)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3    Rassenti, L.4    Rai, K.R.5    Weiss, A.6    Kipps, T.J.7
  • 35
    • 63749084353 scopus 로고    scopus 로고
    • Characteristics associated with important clinical end points in patients with chronic lymphocytic leukemia at initial treatment
    • A multivariable model with characteristics predictingimportant clinical end points was developed in this article
    • Wierda WG, O'Brien S, Wang X, et al. Characteristics associated with important clinical end points in patients with chronic lymphocytic leukemia at initial treatment. J Clin Oncol. 2009;27 (10):1637-43. A multivariable model with characteristics predictingimportant clinical end points was developed in this article.
    • (2009) J Clin Oncol , vol.27 , Issue.10 , pp. 1637-1643
    • Wierda, W.G.1    O'brien, S.2    Wang, X.3
  • 36
    • 77956632843 scopus 로고    scopus 로고
    • Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL)
    • Zenz T, Frohling S, Mertens D, et al. Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL). Best Pract Res Clin Haematol. 2010;23(1):71-84.
    • (2010) Best Pract Res Clin Haematol , vol.23 , Issue.1 , pp. 71-84
    • Zenz, T.1    Frohling, S.2    Mertens, D.3
  • 37
    • 0344729013 scopus 로고    scopus 로고
    • Chlorambucil in indolent chronic lymphocytic leukemia. French cooperative group on chronic lymphocytic leukemia
    • Dighiero G, Maloum K, Desablens B, et al. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med.1998;338(21):1506-14.
    • (1998) N Engl J Med , vol.338 , Issue.21 , pp. 1506-1514
    • Dighiero, G.1    Maloum, K.2    Desablens, B.3
  • 38
    • 79959995569 scopus 로고    scopus 로고
    • Experience with rituximab immunotherapy as an early intervention in patients with Rai stage 0to II chronic lymphocytic leukemia
    • Ferrajoli A, Keating MJ, O'Brien S, et al. Experience with rituximab immunotherapy as an early intervention in patients with Rai stage 0to II chronic lymphocytic leukemia. Cancer. 2011;117(14):3182-6.
    • (2011) Cancer , vol.117 , Issue.14 , pp. 3182-3186
    • Ferrajoli, A.1    Keating, M.J.2    O'brien, S.3
  • 39
    • 55749093568 scopus 로고    scopus 로고
    • Early treatment of high-riskchronic lymphocytic leukemia with alemtuzumab and rituximab
    • Zent CS, Call TG, Shanafelt TD, et al. Early treatment of high-riskchronic lymphocytic leukemia with alemtuzumab and rituximab. Cancer. 2008;113(8):2110-8.
    • (2008) Cancer , vol.113 , Issue.8 , pp. 2110-2118
    • Zent, C.S.1    Call, T.G.2    Shanafelt, T.D.3
  • 40
    • 75649140955 scopus 로고    scopus 로고
    • How i treat CLL up front
    • Gribben JG. How I treat CLL up front. Blood. 2010;115(2):187-97.
    • (2010) Blood , vol.115 , Issue.2 , pp. 187-197
    • Gribben, J.G.1
  • 44
    • 79955007785 scopus 로고    scopus 로고
    • Evidence-based mini-review: The role ofalkylating agents in the initial treatment of chronic lymphocytic leukemia patients with the 11q deletion
    • Ding W, Ferrajoli A. Evidence-based mini-review: the role ofalkylating agents in the initial treatment of chronic lymphocytic leukemia patients with the 11q deletion. Hematology Am Soc Hematol Educ Program. 2010;2010:90-2.
    • (2010) Hematology Am Soc Hematol Educ Program , vol.2010 , pp. 90-92
    • Ding, W.1    Ferrajoli, A.2
  • 45
    • 80053366228 scopus 로고    scopus 로고
    • Incidence of therapyrelated myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine:long-term follow-up of US Intergroup Study E2997
    • Smith MR, Neuberg D, Flinn IW, et al. Incidence of therapyrelated myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine:long-term follow-up of US Intergroup Study E2997. Blood.2011;118(13):3525-7.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3525-7
    • Smith, M.R.1    Neuberg, D.2    Flinn, I.W.3
  • 46
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712 (CALGB 9712)
    • DOI 10.1182/blood-2002-04-1258
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatmentwith rituximab in symptomatic, untreated patients with B-cellchronic lymphocytic leukemia: results from Cancer and LeukemiaGroup B 9712 (CALGB 9712). Blood. 2003;101(1):6-14. (Pubitemid 36025880)
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 47
    • 79954435811 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survivaland progression-free survival in chronic lymphocytic leukemia: Longtermfollow-up of CALGB study 9712
    • Woyach JA, Ruppert AS, Heerema NA, et al. Chemoimmunotherapy with fludarabine and rituximab produces extended overall survivaland progression-free survival in chronic lymphocytic leukemia: longtermfollow-up of CALGB study 9712. J Clin Oncol. 2011;29(10):1349-55.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1349-55
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3
  • 48
    • 55549097826 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European Group for Blood and Marrow Transplantation analysis
    • Schetelig J, van Biezen A, Brand R, et al. Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis. J Clin Oncol. 2008;26(31):5094-100.
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5094-5100
    • Schetelig, J.1    Van Biezen, A.2    Brand, R.3
  • 49
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy [8]
    • DOI 10.1056/NEJM200208083470619
    • Stilgenbauer S, Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N Engl J Med. 2002;347(6):452-3. (Pubitemid 34851846)
    • (2002) New England Journal of Medicine , vol.347 , Issue.6 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 51
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating highresponse rates in genetically high-risk disease
    • Lin TS, Ruppert AS, Johnson AJ, et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating highresponse rates in genetically high-risk disease. J Clin Oncol. 2009;27(35):6012-8.
    • (2009) J Clin Oncol , vol.27 , Issue.35 , pp. 6012-6018
    • Lin, T.S.1    Ruppert, A.S.2    Johnson, A.J.3
  • 52
    • 79551499597 scopus 로고    scopus 로고
    • What is the best frontline therapy for patients with CLL and 17p deletion?
    • Badoux XC, Keating MJ, Wierda WG. What is the best frontline therapy for patients with CLL and 17p deletion? Curr HematolMalig Rep. 2011;6(1):36-46.
    • (2011) Curr HematolMalig Rep , vol.6 , Issue.1 , pp. 36-46
    • Badoux, X.C.1    Keating, M.J.2    Wierda, W.G.3
  • 54
    • 70450233582 scopus 로고    scopus 로고
    • Standardized MRDflow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: A comparativeanalysis
    • Bottcher S, Stilgenbauer S, Busch R, et al. Standardized MRDflow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparativeanalysis. Leukemia. 2009;23(11):2007-17.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2007-2017
    • Bottcher, S.1    Stilgenbauer, S.2    Busch, R.3
  • 55
    • 84870836520 scopus 로고    scopus 로고
    • Minimal residual disease quantification is an independent predictor of progression free and overall survival in chronic lymphocytic leukemia. A multivariate analysis from the randomized GCLLSG CLL8 trial
    • in press
    • Böttcher S, Ritgen M, Fischer K, et al. Minimal residual disease quantification is an independent predictor of progression free and overall survival in chronic lymphocytic leukemia. A multivariate analysis from the randomized GCLLSG CLL8 trial. J Clin Oncol. 2011; (in press).
    • (2011) J Clin Oncol
    • Böttcher, S.1    Ritgen, M.2    Fischer, K.3
  • 59
    • 78650017999 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous alemtuzumab after fludarabine and rituximab induction therapy for previously untreated chronic lymphocytic leukemia: Final analysis of CALGB 10101
    • Lin TS, Donohue KA, Byrd JC, et al. Consolidation therapy with subcutaneous alemtuzumab after fludarabine and rituximab induction therapy for previously untreated chronic lymphocytic leukemia: final analysis of CALGB 10101. J Clin Oncol. 2010;28(29):4500-6.
    • (2010) J Clin Oncol , vol.28 , Issue.29 , pp. 4500-4506
    • Lin, T.S.1    Donohue, K.A.2    Byrd, J.C.3
  • 60
    • 57649088296 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: Long-term follow-up of a randomized phase iii trial of the german cll study group (GCLLSG)
    • Schweighofer CD, Ritgen M, Eichhorst BF, et al. Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG). Br J Haematol. 2009;144(1):95-8.
    • (2009) Br J Haematol , vol.144 , Issue.1 , pp. 95-98
    • Schweighofer, C.D.1    Ritgen, M.2    Eichhorst, B.F.3
  • 61
    • 60949107711 scopus 로고    scopus 로고
    • Rituximab maintenance for the treatment of patients with follicular lymphoma: Systematicreview and meta-analysis of randomized trials
    • Vidal L, Gafter-Gvili A, Leibovici L, et al. Rituximab maintenance for the treatment of patients with follicular lymphoma: systematicreview and meta-analysis of randomized trials. J Natl Cancer Inst. 2009;101(4):248-55.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.4 , pp. 248-255
    • Vidal, L.1    Gafter-Gvili, A.2    Leibovici, L.3
  • 62
    • 37549046061 scopus 로고    scopus 로고
    • Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with B-cell chronic lymphocytic leukemia
    • Del Poeta G, Del Principe MI, Buccisano F, et al. Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with B-cell chronic lymphocytic leukemia.Cancer. 2008;112(1):119-28.
    • (2008) Cancer , vol.112 , Issue.1 , pp. 119-128
    • Del Poeta, G.1    Del Principe, M.I.2    Buccisano, F.3
  • 63
    • 80053350801 scopus 로고    scopus 로고
    • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
    • Badoux XC, Keating MJ, Wen S, et al. Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.Blood. 2011;118(13):3489-98.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3489-3498
    • Badoux, X.C.1    Keating, M.J.2    Wen, S.3
  • 64
    • 79551472206 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab combined with oral dexamethasone followed byalemtuzumab maintenance or allo-sct in cll with 17p-or refractory to fludarabine -Interim analysis of the cll2o trial of the gcllsg and fcgcll/mw
    • Stilgenbauer S, Cymbalista F, Leblond V, et al. Subcutaneous Alemtuzumab Combined with Oral Dexamethasone, Followed byAlemtuzumab Maintenance or Allo-SCT In CLL with 17p-or Refractory to Fludarabine -Interim Analysis of the CLL2O Trial of the GCLLSG and FCGCLL/MW. ASH Annual MeetingAbstracts. 2010;116(21):920.
    • (2010) ASH Annual MeetingAbstracts , vol.116 , Issue.21 , pp. 920
    • Stilgenbauer, S.1    Cymbalista, F.2    Leblond, V.3
  • 65
    • 38049141530 scopus 로고    scopus 로고
    • Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemia
    • Sorror ML, Storer BE, Maloney DG, et al. Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemia. Blood. 2008;111(1):446-52.
    • (2008) Blood , vol.111 , Issue.1 , pp. 446-452
    • Sorror, M.L.1    Storer, B.E.2    Maloney, D.G.3
  • 66
    • 54449093967 scopus 로고    scopus 로고
    • Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • Sorror ML, Storer BE, Sandmaier BM, et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol. 2008;26(30):4912-20.
    • (2008) J Clin Oncol , vol.26 , Issue.30 , pp. 4912-4920
    • Sorror, M.L.1    Storer, B.E.2    Sandmaier, B.M.3
  • 68
    • 20644447584 scopus 로고    scopus 로고
    • Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    • Moreno C, Villamor N, Colomer D, et al. Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia. J Clin Oncol. 2005;23(15):3433-8.
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3433-3438
    • Moreno, C.1    Villamor, N.2    Colomer, D.3
  • 69
    • 77957743452 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
    • This trial demonstrates that patients with and without 17p-show similar survival after alloSCT
    • Dreger P, Dohner H, Ritgen M, et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood. 2010;116 (14):2438-47. This trial demonstrates that patients with and without 17p-show similar survival after alloSCT.
    • (2010) Blood , vol.116 , Issue.14 , pp. 2438-2447
    • Dreger, P.1    Dohner, H.2    Ritgen, M.3
  • 70
    • 79958041684 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation can overcome the adverse prognostic impact of tp53 mutation in chronic lymphocytic leukemia (CLL): Results from the GCLLSG CLL3x Trial
    • Zenz T, Dreger P, Dietrich S, et al. Allogeneic stem cell transplantation can overcome the adverse prognostic impact of tp53 mutation in chronic lymphocytic leukemia (CLL): Results from the GCLLSG CLL3x Trial. ASH Annual Meeting Abstracts. 2010;116(21):2357.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 2357
    • Zenz, T.1    Dreger, P.2    Dietrich, S.3
  • 72
    • 77950321929 scopus 로고    scopus 로고
    • Bendamustine combined with Rituximab (BR) in first-line therapy of advanced CLL: A multicenter phase ii trial of the german cll study group (GCLLSG)
    • Fischer K, Cramer P, Stilgenbauer S, et al. Bendamustine combined with Rituximab (BR) in first-line therapy of advanced CLL: A multicenter phase II trial of the German CLL Study Group (GCLLSG). ASH Annual Meeting Abstracts. 2009;114 (22):205.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 205
    • Fischer, K.1    Cramer, P.2    Stilgenbauer, S.3
  • 73
    • 77953208700 scopus 로고    scopus 로고
    • Results of the phase II NCRI CLL206 trial of alemtuzumab in combination with high-dose methylprednisolonefor high-risk (17p-)
    • abstract 0351
    • Pettitt AR,Matutes E, Dearden C, et al. Results of the phase II NCRI CLL206 trial of alemtuzumab in combination with high-dose methylprednisolonefor high-risk (17p-) CLL. Haematologica. 2009;94 (Suppl2):138. abstract 0351.
    • (2009) CLL. Haematologica , vol.94 , Issue.SUPPL.2 , pp. 138
    • Pettitt Armatutes, E.1    Dearden, C.2
  • 74
    • 80052180048 scopus 로고    scopus 로고
    • Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia
    • Parikh SA, Keating MJ, O'Brien S, et al. Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia. Blood. 2011;118(8):2062-8.
    • (2011) Blood. , vol.118 , Issue.8 , pp. 2062-2068
    • Parikh, S.A.1    Keating, M.J.2    O'brien, S.3
  • 75
    • 84870794834 scopus 로고    scopus 로고
    • Efficacy and safety of a first line combined therapeutic approach for young CLL patientswith advanced or progressive disease stratified according to the biologic features: First analysis of the GIMEMA multicenter study LLC0405
    • Mauro FR, Molica S, Cortelezzi A, et al. Efficacy and safety of a first line combined therapeutic approach for young CLL patientswith advanced or progressive disease stratified according to the biologic features: first analysis of the GIMEMA multicenter study LLC0405. ASH Annual Meeting Abstracts. 2010;116(21):2471.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 2471
    • Mauro, F.R.1    Molica, S.2    Cortelezzi, A.3
  • 76
    • 79959190996 scopus 로고    scopus 로고
    • Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocyticleukemia
    • Wierda WG, Kipps TJ, Durig J, et al. Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocyticleukemia. Blood. 2011;117(24):6450-8.
    • (2011) Blood , vol.117 , Issue.24 , pp. 6450-6458
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3


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