The vitreous glycoprotein opticin inhibits preretinal neovascularization

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 1, 2012, Pages 228-234

  le Goff, Magali M ^a   Lu, Hongbin ^a   Ugarte, Marta ^a,b   Henry, Stephen ^c   Takanosu, Masamine ^d   Mayne, Richard ^d   Bishop, Paul N ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBRIL; COLLAGEN TYPE 2; GLYCOPROTEIN; OPTICIN; RECOMBINANT OPTICIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; OPTC PROTEIN, MOUSE; OXYGEN; PEPTIDE FRAGMENT; PROTEOGLYCAN; SCLEROPROTEIN;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOWMAN MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IRIS; KNOCKOUT MOUSE; LENS CAPSULE; MOUSE; NONHUMAN; POSTERIOR EYE SEGMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETINA NEOVASCULARIZATION; RETINOPATHY; TRABECULAR MESHWORK; VITREOUS BODY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE MODEL; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; INTRAVITREAL DRUG ADMINISTRATION; METABOLISM; MOUSE MUTANT; NEWBORN; PATHOLOGY;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOENZYME TECHNIQUES; INTRAVITREAL INJECTIONS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXYGEN; PEPTIDE FRAGMENTS; PROTEOGLYCANS; RECOMBINANT PROTEINS; RETINAL NEOVASCULARIZATION; VITREOUS BODY;

EID: 84859238559     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8514     Document Type: Article

References (35)

1. Reardon AJ, Le Goff MM, Briggs M, et al. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem. 2000;275:2123-2129.
2. Frolova EI, Kokina VM, Beebe DC. The expression pattern of opticin during chicken embryogenesis. Gene Expr Patterns. 2004; 4:335-338.
3. Monfort J, Tardif G, Roughley P, et al. Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. Osteoarthritis Cartilage. 2008;16:749-755.
4. Schaefer L, Iozzo RV. Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem. 2008;283:21305-21309.
5. McEwan PA, Scott PG, Bishop PN, Bella J. Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans. J Struct Biol. 2006;155:294-305.
6. Le Goff MM, Hindson VJ, Jowitt TA, Scott PG, Bishop PN. Characterization of opticin and evidence of stable dimerization in solution. J Biol Chem. 2003;278:45280-45287.
7. Bishop PN, Takanosu M, Le Goff M, Mayne R. The role of the posterior ciliary body in the biosynthesis of vitreous humour. Eye. 2002;16:454-460.
8. Takanosu M, Boyd TC, Le Goff MM, et al. Structure, chromosomal location and tissue-specific expression of the mouse opticin gene. Invest Ophthalmol Vis Sci. 2001;42:2202-2210.
9. Halfter W, Dong S, Schurer B, Ring C, Cole GJ, Eller A. Embryonic synthesis of the inner limiting membrane and vitreous body. Invest Ophthalmol Vis Sci. 2005;46:2202-2209.
10. Wistow G, Bernstein SL, Ray S, et al. Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroidresponse factors and similarities with retinal pigment epithelium. Mol Vis. 2002;8:185-195.
11. Hindson VJ, Gallagher JT, Halfter W, Bishop PN. Opticin binds to heparan and chondroitin sulfate proteoglycans. Invest Ophthalmol Vis Sci. 2005;46:4417-4423.
12. Sanders EJ, Walter MA, Parker E, Aramburo C, Harvey S. Opticin binds retinal growth hormone in the embryonic vitreous. Invest Ophthalmol Vis Sci. 2003;44:5404-5409.
13. Saint-Geniez M, D'Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol. 2004;48: 1045-1058.
14. Lutty GA, Thompson DC, Gallup JY, Mello RJ, Patz A, Fenselau A. Vitreous: an inhibitor of retinal extract-induced neovascularization. Invest Ophthalmol Vis Sci. 1983;24:52-56.
15. Heidary G, Vanderveen D, Smith LE. Retinopathy of prematurity: current concepts in molecular pathogenesis. Semin Ophthalmol. 2009;24:77-81.
16. Frank RN. Diabetic retinopathy. N Engl J Med. 2004;350:48-58.
17. Smith LEH, Wesolowski E, McLellan A, et al. Oxygen-induced retinopathy in the mice. Invest Ophthalmol Vis Sci. 1994;35:101-111.
18. Ramesh S, Bonshek RE, Bishop PN. Immunolocalisation of opticin in the human eye. Br J Ophthalmol. 2004;88:697-702.
19. Stahl A, Connor KM, Sapieha P, et al. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009;12:297-301.
20. Stahl A, Connor KM, Sapieha P, et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010;51:2813-2826.
21. Vanhaesebrouck S, Daniels H, Moons L, Vanhole C, Carmeliet P, De Zegher F. Oxygen-induced retinopathy in mice: amplification by neonatal IGF-1 deficit and attenuation by IGF-1 administration. Pediatr Res. 2009;65:307-310.
22. Hobby P, Wyatt MK, Gan W, et al. Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye. Mol Vis. 2000;6: 72-78.
23. Friedman SJ, Faucher M, Hiscott P, et al. Protein localization in the human eye and genetic screen of opticin. Hum Mol Genet. 2002; 11:1333-1342.
24. Ito M, Yoshioka M. Regression of the hyaloid vessels and papillary membrane of the mouse. Anat Embryol. 1999;200:403-411.
25. Fukai N, Eklund L, Marneros AG, et al. Lack of collagen XVIII/ endostatin results in eye abnormalities. EMBO J. 2002;21:1535-1544.
26. Dawson DW, Volpert OV, Gillis P, et al. Pigment epitheliumderived factor: a potent inhibition of angiogenesis. Science. 1999; 285:245-248.
27. Sheibani N, Sorenson CM, Cornelius LA, Frazier WA. Thrombospondin- 1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia. Biochem Biophys Res Commun. 2000;267:257-261.
28. Määttä M, Heljasvaara R, Pihlajaniemi T, Uusitalo M. Collagen XVIII/endostatin shows a ubiquitous distribution in human ocular tissues and endostatin-containing fragments accumulate in ocular fluid samples. Graefes Arch Clin Exp Ophthalmol. 2007; 245:74-81.
29. Mori K, Duh E, Gehlbach P, et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularisation. J Cell Physiol. 2001;188:253-263.
30. Zhang M, Yang Y, Yan M, Zhang J. Downregulation of vascular endothelial growth factor and integrin β3 by endostatin in a mouse model of retinal neovascularisation. Exp Eye Res. 2006;82:74-80.
31. Wu Z, Wang S, Sorenson CM, Sheibani N. Attenuation of retinal vascular development and neovascularisation in transgenic mice over-expressing thrombospondin-1 in the lens. Dev Dyn. 2006; 235:1908-1920.
32. Wang S, Wu Z, Sorenson CM, Lawler J, Sheibani N. Thrombospondin- 1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxiamediated vessel obliteration. Dev Dyn. 2003;228:630-642.
33. Hurskainen M, Eklund L, Hägg PO, et al. Abnormal maturation of the retinal vasculature in type XVIII collagen/endostatin deficient mice and changes in retinal glial cells due to lack of collagen types XV and XVIII. FASEB J. 2005;19:1564-1566.
34. Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest. 2006;116: 369-377.
35. Maier AK, Kociok N, Zahn G, et al. Modulation of hypoxia-induced neovascularization by JSM6427, an integrin α5β1 inhibiting molecule. Curr Eye Res. 2007;32:801-812.