Expressed sequence tag analysis of adult human iris for the NEIBank project: Steroid-response factors and similarities with retinal pigment epithelium

Molecular Vision

Volumn 8, Issue , 2002, Pages 185-195

  Wistow, Graeme ^a   Bernstein, Steven L ^b   Ray, Sugata ^a   Wyatt, M Keith ^a   Behal, Amita ^a   Touchman, Jeffrey W ^c   Bouffard, Gerard ^c   Smith, Don ^a   Peterson, Katherine ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; MOLECULAR MARKER; RAS PROTEIN; STEROID; ZINC FINGER PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHOROID MELANOMA; CONTROLLED STUDY; DNA LIBRARY; DNA MICROARRAY; EXPRESSED SEQUENCE TAG; EYE DEVELOPMENT; GENE AMPLIFICATION; GENE CLUSTER; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; GLAUCOMA; HUMAN; HUMAN TISSUE; INTRAOCULAR PRESSURE; IRIS; MOLECULAR CLONING; NEIBANK; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; SEQUENCE ANALYSIS; SEQUENCE DATABASE; STANDARD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; DATABASES, GENETIC; DNA, COMPLEMENTARY; EXPRESSED SEQUENCE TAGS; EYE PROTEINS; GENE EXPRESSION PROFILING; GLUCOCORTICOIDS; HUMANS; IRIS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NATIONAL INSTITUTES OF HEALTH (U.S.); OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPHTHALMOLOGY; PIGMENT EPITHELIUM OF EYE; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; UNITED STATES;

EID: 0346949039     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Chang B, Smith RS, Hawes NL, Anderson MG, Zabaleta A, Savinova O, Roderick TH, Heckenlively JR, Davisson MT, John SW. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 1999; 21:405-9.
2. McAvoy JW, Chamberlain CG, de Iongh RU, Hales AM, Lovicu FJ. Lens development. Eye 1999; 13:425-37.
3. Thumann G. Development and cellular functions of the iris pigment epithelium. Surv Ophthalmol 2001; 45:345-54.
4. Shields JA, Shields CL, De Potter P, Singh AD. Diagnosis and treatment of uveal melanoma. Semin Oncol 1996; 23:763-7.
5. Escribano J, Ortego J, Coca-Prados M. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. J Biochem (Tokyo) 1995; 118:921-31.
6. Coca-Prados M, Escribano J, Ortego J. Differential gene expression in the human ciliary epithelium. Prog Retin Eye Res 1999; 18:403-29.
7. Wistow G. A project for ocular bioinformatics: NEIBank. Mol Vis 2002; 8:161-3 .
8. Simms D. mRNA isolation for high quality cDNA. Focus 1995; 17:39-42.
9. Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K. Expressed sequence tag analysis of adult human lens for the NEIBank Project: Over 2000 non-redundant transcripts, novel genes and splice variants. Mol Vis 2002; 8:171-84 .
10. Wistow G, Bernstein SL, Touchman JW, Bouffard G, Wyatt MK, Peterson K, Gao J, Buchoff P, Smith D. Grouping and identification of sequence tags (GRIST): Bioinformatics tools for the NEIBank database. Mol Vis 2002; 8:164-70 .
11. Bateman A, Birney E, Durbin R, Eddy SR, Howe KL, Sonnhammer EL. The Pfam protein families database. Nucleic Acids Res 2000; 28:263-6.
12. Schultz J, Copley RR, Doerks T, Ponting CP, Bork P. SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res 2000; 28:231-4.
13. Kumar S, Tamura K, Nei M. MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers. Comput Appl Biosci 1994; 10:189-91.
14. Reddy VN. Glutathione and its function in the lens--an overview. Exp Eye Res 1990; 50:771-8.
15. Spector A, Ma W, Wang RR. The aqueous humor is capable of generating and degrading H2O2. Invest Ophthalmol Vis Sci 1998; 39:1188-97.
16. Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: Over 6000 non-redundant transcripts, novel genes and splice variants. Mol Vis 2002; 8:205-20 .
17. Gerashchenko DY, Beuckmann CT, Marcheselli VL, Gordon WC, Kanaoka Y, Eguchi N, Urade Y, Hayaishi O, Bazan NG. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Invest Ophthalmol Vis Sci 1998; 39:198-203.
18. Goh Y, Nakajima M, Azuma I, Hayaishi O. Prostaglandin D2 reduces intraocular pressure. Br J Ophthalmol 1988; 72:461-4.
19. Iozzo RV. The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem 1999; 274:18843-6.
20. Hobby P, Ward FJ, Denbury AN, Williams DG, Staines NA, Sutton BJ. Molecular modeling of an anti-DNA autoantibody (V-88) and mapping of its V region epitopes recognized by heterologous and autoimmune antibodies. J Immunol 1998; 161:2944-52.
21. Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem 2000; 275:2123-9.
22. Friedman JS, Ducharme R, Raymond V, Walter MA. Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection. Invest Ophthalmol Vis Sci 2000; 41:2059-66.
23. Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC. Identification of a gene that causes primary open angle glaucoma. Science 1997; 275:668-70.
24. Johnson DH. Myocilin and glaucoma: a TIGR by the tail? Arch Ophthalmol 2000; 118:974-8.
25. Weber BH, Vogt G, Pruett RC, Stohr H, Felbor U. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genet 1994; 8:352-6.
26. Stoilov I, Akarsu AN, Sarfarazi M. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum Mol Genet 1997; 6:641-7.
27. Adema GJ, de Boer AJ, Vogel AM, Loenen WA, Figdor CG. Molecular characterization of the melanocyte lineage-specific antigen gp100. J Biol Chem 1994; 269:20126-33.
28. Solano F, Martinez-Esparza M, Jimenez-Cervantes C, Hill SP, Lozano JA, Garcia-Borron JC. New insights on the structure of the mouse silver locus and on the function of the silver protein. Pigment Cell Res 2000; 13 Suppl 8:118-24.
29. Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 1998; 58:1515-20.
30. Hofmann T, Schaefer M, Schultz G, Gudermann T. Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 2000; 78:14-25.
31. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. J Biol Chem 1999; 274:27439-47.
32. Treisman JE, Lai ZC, Rubin GM. Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. Development 1995; 121:2835-45.
33. Dobens LL, Hsu T, Twombly V, Gelbart WM, Raftery LA, Kafatos FC. The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Mech Dev 1997; 65:197-208.
34. Riccardi C, Cifone MG, Migliorati G. Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ 1999; 6:1182-9.
35. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995; 9:168-81.
36. Wordinger RJ, Clark AF. Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma. Prog Retin Eye Res 1999; 18:629-67.
37. Fingert JH, Clark AF, Craig JE, Alward WL, Snibson GR, McLaughlin M, Tuttle L, Mackey DA, Sheffield VC, Stone EM. Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. Invest Ophthalmol Vis Sci 2001; 42:145-52.
38. Schutz B, Niessing J. Cloning and structure of a chicken zinc finger cDNA: restricted expression in developing neural crest cells. Gene 1994; 148:227-36.
39. Al-Maghtheh M, Vithana E, Tarttelin E, Jay M, Evans K, Moore T, Bhattacharya S, Inglehearn CF. Evidence for a major retinitis pigmentosa locus on 19q13.4 (RP11) and association with a unique bimodal expressivity phenotype. Am J Hum Genet 1996; 59:864-71.
40. Takebayashi K, Akazawa C, Nakanishi S, Kageyama R. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. J Biol Chem 1995; 270:1342-9.
41. Kageyama R, Ohtsuka T. The Notch-Hes pathway in mammalian neural development. Cell Res 1999; 9:179-88.
42. Quaderi NA, Schweiger S, Gaudenz K, Franco B, Rugarli EI, Berger W, Feldman GJ, Volta M, Andolfi G, Gilgenkrantz S, Marion RW, Hennekam RC, Opitz JM, Muenke M, Ropers HH, Ballabio A. Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22. Nat Genet 1997; 17:285-91.
43. Schweiger S, Foerster J, Lehmann T, Suckow V, Muller YA, Walter G, Davies T, Porter H, van Bokhoven H, Lunt PW, Traub P, Ropers HH. The Opitz syndrome gene product, MID1, associates with microtubules. Proc Natl Acad Sci U S A 1999; 96:2794-9.
44. Borden KL. RING fingers and B-boxes: zinc-binding protein-protein interaction domains. Biochem Cell Biol 1998; 76:351-8.
45. Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J Mol Biol 2001; 306:717-26.
46. Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev 2001; 81:153-208.
47. Cherfils J, Chardin P. GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem Sci 1999; 24:306-11.
48. Galiana E, Vernier P, Dupont E, Evrard C, Rouget P. Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Proc Natl Acad Sci U S A 1995; 92:1560-4.
49. Iwasaki K, Toyonaga R. The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission. EMBO J 2000; 19:4806-16.
50. Campochiaro PA. Retinal and choroidal neovascularization. J Cell Physiol 2000; 184:301-10.
51. Moromizato Y, Stechschulte S, Miyamoto K, Murata T, Tsujikawa A, Joussen AM, Adamis AP. CD18 and ICAM-1-dependent corneal neovascularization and inflammation after limbal injury. Am J Pathol 2000; 157:1277-81.
52. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285:245-8.
53. Tsai YJ, Lee RK, Lin SP, Chen YH. Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract. Biochim Biophys Acta 2000; 1492:196-202.
54. Hamada T, Ui-Tei K, Imaki J, Miyata Y. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. Biochem Biophys Res Commun 2001; 280:733-7.
55. Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol 2001; 3:512-6.
56. LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, Giese NA, Lokker NA, Sullivan C, Boldog FL, Yang M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets J, Shimkets RA, Rothberg JM, Lichenstein HS. PDGF-D, a new protease-activated growth factor. Nat Cell Biol 2001; 3:517-21.
57. Bork P, Beckmann G. The CUB domain. A widespread module in developmentally regulated proteins. J Mol Biol 1993; 231:539-45.
58. Grimmond S, Larder R, Van Hateren N, Siggers P, Hulsebos TJ, Arkell R, Greenfield A. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics 2000; 70:74-81.
59. Kalcheim C, Carmeli C, Rosenthal A. Neurotrophin 3 is a mitogen for cultured neural crest cells. Proc Natl Acad Sci U S A 1992; 89:1661-5.
60. Nakagawara A, Milbrandt J, Muramatsu T, Deuel TF, Zhao H, Cnaan A, Brodeur GM. Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res 1995; 55:1792-7.
61. Ortego J, Escribano J, Crabb J, Coca-Prados M. Identification of a neuropeptide and neuropeptide-processing enzymes in aqueous humor confers neuroendocrine features to the human ocular ciliary epithelium. J Neurochem 1996; 66:787-96.
62. Ortego J, Escribano J, Coca-Prados M. Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett 1997; 413:349-53.
63. Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993; 14:436-41.
64. Planey SL, Litwack G. Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun 2000; 279:307-12.
65. Treisman JE. A conserved blueprint for the eye? Bioessays 1999; 21:843-50.