Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy

Cytokine

Volumn 58, Issue 2, 2012, Pages 253-260

  Veloso, Sergi ^a   Escoté, Xavier ^a,b   Ceperuelo Mallafré, Victòria ^a,c   López Dupla, Miguel ^a   Peraire, Joaquim ^a   Viladés, Consuelo ^a   Domingo, Pere ^d   Castro, Antoni ^e   Olona, Montserrat ^a   Sirvent, Joan Josep ^a   Leal, Manuel ^f   Vendrell, Joan ^a,b   Richart, Cristóbal ^a   Vidal, Francesc ^a  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^f HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Adiponectin; HIV 1; IL18; Leptin; Lipodystrophy

Indexed keywords

ADIPONECTIN; ALANINE; ANTIRETROVIRUS AGENT; ARGININE; CYSTEINE; GLUTAMINE; GLYCINE; INSULIN; INTERLEUKIN 18; LEPTIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIACYLGLYCEROL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; INSULIN RESISTANCE; INTRON; LIPODYSTROPHY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MOLECULAR GENETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEQUENCE ANALYSIS;

ADIPONECTIN; ADULT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INSULIN RESISTANCE; INTERLEUKIN-18; LEPTIN; LIPODYSTROPHY; MALE; MIDDLE AGED;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84859211739     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.01.013     Document Type: Article

References (48)

1. Carr A., Samaras K., Thorisdottir A., Kaufmann G.R., Chisholm D.J., Cooper D. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia and diabetes mellitus: a cohort study. Lancet 1999, 353:2093-2099.
2. Carr A., Emery S., Law M., Puls R., Lundgren J.D., Powderly W.G. HIV Lipodystrophy Case Definition Study Group, an objective case definition of lipodystrophy in HIV-1-infected adults: a case-control study. Lancet 2003, 361:726-735.
3. Caron-Debarle M., Lagathu C., Boccara F., Vigouroux C., Capeau J. HIV-associated lipodystrophy: from fat injury to premature aging. Trends Mol Med 2010, 16:218-229.
4. Gougeon M.L., Pénicaud L., Fromenty B., Leclercq P., Viard J.P., Capeau J. Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations. Antiviral Ther 2004, 9:161-177.
5. Carr A., Miller A.J., Law M., Cooper D.A. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000, 14:F25-F32.
6. Lagathu C., Bastard J.P., Auclair M., et al. Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antiviral Ther 2004, 9:911-920.
7. Jones J.P., Qazi N., Morelese J., et al. Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens. J Acquir Immune Defic Syndr 2005, 40:565-572.
8. Vigouroux C., Maachi C., Nguyen T.H., et al. Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy. AIDS 2003, 17:1503-1511.
9. Kelesidis T., Kelesidis I., Chou S., Mantzoros C.S. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med 2010, 152:93-100.
10. Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 1996, 334:292-295.
11. Myers G.M., Cowley M.A., Münzberg H. Mechanism of leptin action and leptin resistance. Annu Rev Physiol 2008, 70:537-556.
12. Audi L., Mantzoros C.S., Vidal-Puig A., Vargas D., Gussinye M., Carrascosa A. Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry 1998, 3:544-547.
13. Haque W.A., Shimomura I., Matsuzawa Y., Garg A. Serum adiponectin and leptin levels in patients with lipodystrophies. J Clin Endocrinol Metab 2002, 87:2395-2398.
14. Kosmiski L.A., Bacchetti P., Kotler D.P., et al. Relationship of fat distribution with adipokines in human immunodeficiency virus infection. J Clin Endocrinol Metab 2008, 93:216-224.
15. Estrada V., Serrano-Ríos M., Martínez Larrad M.T., et al. Leptin and adipose tissue maldistribution in HIV-infected male patients with predominant fat loss treated with antiretroviral therapy. J Acquir Immune Defic Syndr 2002, 29:32-40.
16. Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F. Association for the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann Hum Genet 2000, 64:391-394.
17. Su P.H., Chen J.Y., Yu J.S., Chen S.J., Yang S.F. Leptin expression and leptin receptor gene polymorphisms in growth hormone deficiency patients. Hum Genet 2011, 129:455-462.
18. Fain J.N., Buehrer B., Tichansky D.S., Madan A.K. Regulation of adiponectin release and demonstration of adiponectin mRNA as well as release by the non-fat cells of human omental adipose tissue. Int J Obes (Lond) 2008, 32:429-435.
19. Arita Y., Kihara S., Ouchi N., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999, 257:79-83.
20. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006, 116:1784-1792.
21. Kosmiski L., Kuritzkes D., Lichtenstein K., Eckel R. Adipocyte-derived hormone levels in HIV lipodystrophy. Antiviral Ther 2003, 8:9-15.
22. Sweeney L.L., Brennan A.M., Mantzoros C.S. The role of adipokines in relation to HIV lipodystrophy. AIDS 2007, 21:895-904.
23. Xu A., Yin S., Wong L., Chan K.W., Lam K.S. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 2004, 145:487-494.
24. Zacharova J., Chiasson J.L., Laakso M. STOP-NIDDM Study Group, The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2005, 54:893-899.
25. Rasmussen-Torvik L.J., Pankow J.S., Jacobs D.R., Steinberger J., Moran A., Sinaiko A.R. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet 2009, 125:21-28.
26. Mazodier K., Marin V., Novick D., et al. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood 2005, 106:3483-3489.
27. Torre D., Speranza F., Martegani R., et al. Circulating levels of IL-18 in adult and paediatric patients with HIV-1 infection. AIDS 2000, 14:2211-2212.
28. Pugliese A., Gennero L., Vidotto V., Speranza F., Tambini R., Torre D. Interleukin-18 enhances HIV-1 production in a human chronically-infected T cell line (H9-V). Cell Biochem Funct 2002, 20:333-337.
29. Choi H.J., Dinarello C.A., Shapiro L. Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells. J Infect Dis 2001, 184:560-568.
30. Chen D.Y., Chen Y.M., Chen H.H., Hsieh C.W., Lin C.C., Lan J.L. Functional association of interleukin 18 gene -607 (C/A) promoter polymorphisms with disease course in Chinese patients with adult-onset Still's disease. J Rheumatol 2009, 10:2284-2289.
31. Trinca J.R., Sprinz E., Lazzaretti R.K., et al. SNPs in the APM1 gene promoter are associated with adiponectin levels in HIV-infected individuals receiving HAART. J Acquir Immune Defic Syndr 2010, 55:299-305.
32. Marzocchetti A., Schwarz J., Di Giambenedetto S.M., et al. The effect of polymorphism in candidate genes of the long-term risk of lipodystrophy and dyslipidemia in HIV-infected white patients starting antiretroviral therapy. AIDS Res Hum Retrov 2011, 27:1299-1309.
33. Castelar L., Silva M.M., Castelli E.C., et al. Interleukin-18 and interferon gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome. Tissue Antigens 2010, 76:126-130.
34. Saumoy M., López-Dupla M., Veloso S., et al. The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes. AIDS 2008, 22:893-896.
35. Saumoy M., Veloso S., Alonso-Villaverde C., et al. PPAR gamma polymorphism in HIV-1-infected patients with HAART-related lipodystrophy. Curr HIV Res 2009, 7:533-540.
36. Veloso S., Olona M., Peraire J., et al. No relationship between TNF-alpha genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV-1-infected patients: a case-control study and a meta-analysis. AIDS Res Hum Retrov 2011, 27:143-152.
37. Escoté X., Megia A., López-Dupla M., et al. A study of fatty acid binding protein 4 in HIV-1 infection and in combination antiretroviral therapy-related metabolic disturbances and lipodystrophy. HIV Med 2011, 12:428-437.
38. Escoté X., Miranda M., Veloso S., et al. Lipodystrophy and insulin resistance in combination antiretroviral treated HIV-1-infected patients: implication of resistin. J Acquir Immune Defic Syndr 2011, 57:16-23.
39. Mynarcik D.C., Combs T., McNurlan M.A., Scherer P.E., Komaroff E., Gelato M.C. Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. J Acquir Immune Defic Syndr 2002, 31:514-520.
40. Luo L., Zhang L., Tao M., et al. Adiponectin and leptin levels in Chinese patients with HIV-related lipodystrophy: a 30-month prospective study. AIDS Res Hum Retrov 2009, 25:1265-1272.
41. Johnson J.A., Albu J.B., Engelson E.S., et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab 2004, 286:E261-E271.
42. Nagy G.S., Tsiodras S., Martin L.D., et al. Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentration of leptin. Clin Infect Dis 2003, 36:795-802.
43. Mulligan K., Khatami H., Schwarz J.M., et al. The effects of recombinant human leptin on visceral fat, dyslipemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. J Clin Endocrinol Metab 2009, 94:1137-1144.
44. Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7:941-946.
45. Sutinen J., Korsheninnikova E., Funahashi T., Matsuzawa Y., Nyman T., Yki-Järvinen H. Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. J Clin Endocrinol Metab 2003, 88:1907-1910.
46. Lindegaard B., Hansen A.B., Gerstoft J., Pedersen B.K. High plasma levels of interleukin-18 in HIV-infected subjects with lipodystrophy. J Acquir Immune Defic Syndr 2004, 36:588-593.
47. Domingo P., Matias-Guiu X., Pujol R.M., et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 1999, 13:2261-2267.
48. Magkos F., Brennan A., Sweeney L., et al. Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study. Metabolism 2011, 60:1045-1049.