Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome

Tissue Antigens

Volumn 76, Issue 2, 2010, Pages 126-130

  Castelar, L ^a   Silva, M M ^a   Castelli, E C ^a   Deghaide, N H S ^a   Mendes Junior, C T ^a   MacHado, A A ^a   Donadi, E A ^a   Fernandes, A P M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

highly active antiretroviral therapy; human immunodeficiency virus 1; human immunodeficiency virus associated lipodystrophy syndrome; interferon gamma; interleukin 18

Indexed keywords

CHOLESTEROL; GAMMA INTERFERON; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 18; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ALLELE; ARTICLE; BODY FAT DISTRIBUTION; BRAZIL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RESISTANCE; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LIPODYSTROPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BASE SEQUENCE; BRAZIL; CASE-CONTROL STUDIES; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HIV INFECTIONS; HIV-1; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-18; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77954347656     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01471.x     Document Type: Article

References (24)

1. Palella FJ Jr, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998 : 338 : 853 860.
2. Martinez E, Mocroft A, Garcia-Viejo MA et al. Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study. Lancet 2001 : 357 : 592 598.
3. Madge S, Kinloch-de-Loes S, Mercey D, Johnson MA, Weller IV. Lipodystrophy in patients naïve to HIV protease inhibitors. AIDS 1999 : 13 : 735 737.
4. Carr A, Samaras K, Burton S et al. A syndrome of peripheral lipodystrophy, hyperlipidemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998 : 12 : 51 8.
5. Shaw AJ, McLean KA, Evans BA. Disorders of fat distribution in HIV infection. Int J STD AIDS 1998 : 9 : 595 599.
6. Duran S, Savès M, Spire B et al. Failure to maintain long-term adherence to highly active antiretroviral therapy: the role of lipodystrophy. AIDS 2001 : 15 : 2441 2444.
7. Sevastianova K, Sutinen J, Kannisto K, Hamsten A, Ristola M, Yki-Järvinen H. Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy. Am J Physiol Endocrinol Metab 2008 : 295 : E85 91.
8. Lagathu C, Bastard JP, Auclair M et al. Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antivir Ther 2004 : 9 : 911 920.
9. Lindegaard B, Hansen AB, Pilegaard H, Keller P, Gerstoft J, Pedersen BK. Adipose tissue expression of IL-18 and HIV associated lipodystrophy. AIDS 2004 : 18 : 1956 1958.
10. Lihn AS, Richelsen B, Pedersen SB et al. Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels. Am J Physiol Endocrinol Metab 2003 : 285 : E1072 80.
11. Johnson JA, Albu JB, Engelson ES et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab 2004 : 286 : E261 71.
12. Lindegaard B, Hansen AB, Gerstoft J, Pedersen BK. High plasma level of interleukin-18 in HIV-infected subjects with lipodystrophy. J Acquir Immune Defic Syndr 2004 : 36 : 588 593.
13. Christeff N, Melchior JC, de Truchis P, Perronne C, Gougeon ML. Increased serum interferon alpha in HIV-1 associated lipodystrophy syndrome. Eur J Clin Invest 2002 : 32 : 43 50.
14. Gasic S, Tian B, Green A. Tumor necrosis factor alpha stimulates lipolysis in adipocytes by decreasing Gi protein concentrations. J Biol Chem 1999 : 274 : 6770 6775.
15. Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol 2001 : 112 : 146 152.
16. Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high INF-gamma production. Hum Immunol 2000 : 61 : 863 866.
17. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992 : 48 : 361 372.
18. Raymond M, Rousset F. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 1995 : 86 : 248 249.
19. Raymond M, Rousset F. An exact test for population differentiation. Evolution 1995 : 49 : 1280 1283.
20. Excoffier L, Laval G, Schneider S. Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evol Bioinform Online 2005 : 1 : 47 50.
21. Excoffier L, Slatkin M. Incorporating genotypes of relatives into a test of linkage disequilibrium. Am J Hum Genet 1998 : 62 : 171 180.
22. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001 : 68 : 978 989.
23. Song W, Wilson CM, Allen S et al. Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults. Clin Exp Immunol 2006 : 144 : 117 124.
24. Norbiato G, Trifirò G, Galli M, Gervasoni C, Clerici M. Fat redistribution in HIV-infected patients. A new hormonal-immune disorder? Ann N Y Acad Sci 2000 : 917 : 951 955.