SNPs in the APM1 gene promoter are associated with adiponectin levels in HIV-infected individuals receiving HAART

Journal of Acquired Immune Deficiency Syndromes

Volumn 55, Issue 3, 2010, Pages 299-305

  Trinca, Juciane R ^a   Sprinz, Eduardo ^b   Lazzaretti, Rosmeri K ^b   Hutz, Mara H ^c   Kuhmmer, Regina ^b   De Almeida, Silvana ^a   Tibola, Analise ^d   Meirelles, Gustavo B ^e   Arena De Souza, Roberto C ^e   Mattevi, Vanessa S ^a  

^a UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSIDADE FEEVALE   (Brazil)

^e UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

adiponectin; HAART; HIV; leptin; lipodystrophy; pharmacogenomics

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; LEPTIN; LEPTIN RECEPTOR; ADIPOQ PROTEIN, HUMAN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; LEPTIN RECEPTOR, HUMAN;

ADULT; ALLELE; ARTICLE; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; DNA POLYMORPHISM; DYSLIPIDEMIA; FEMALE; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID BLOOD LEVEL; LIPODYSTROPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; SKINFOLD THICKNESS; WAIST CIRCUMFERENCE; BLOOD; CHEMICALLY INDUCED; COMPLICATION; GENETICS; HIV ASSOCIATED LIPODYSTROPHY; HIV INFECTIONS; MIDDLE AGED;

ADIPONECTIN; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; HIV INFECTIONS; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; LEPTIN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, LEPTIN;

EID: 78049289406     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181ecfeb7     Document Type: Article

References (51)

1. Bradbury RA, Samaras K. Antiretroviral therapy and the human immunodeficiency virus\-improved survival but at what cost? Diabetes Obes Metab 2008, 10, 441-450.
2. Walensky RP, Paltiel AD, Losina E, et al. The survival benefits of AIDS treatment in the United States. J Infect Dis. 2006;194:11-19.
3. Sweeney LL, Brennan AM, Mantzoros CS. The role of adipokines in relation to HIV lipodystrophy. AIDS. 2007;21:895-904.
4. Carr A. HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS. 2003;17(Suppl 1):S141-S148.
5. Prins JB. Adipose tissue as an endocrine organ. Best Pract Res Clin Endocrinol Metab. 2002;16:639-651.
6. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548-2556.
7. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115:911-919.
8. Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997;40:1371-1379.
9. Mynarcik DC, Combs T, McNurlan MA, et al. Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. J Acquir Immune Defic Syndr. 2002;31:514-520.
10. Vigouroux C, Maachi M, Nguyen TH, et al. Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy. AIDS. 2003;17:1503-1511.
11. Tsiodras S, Mantzoros C. Leptin and adiponectin in the HIV associated metabolic syndrome: physiologic and therapeutic implications. Am J Infect Dis. 2006;2:141-152.
12. Poitou C, Lacorte JM, Coupaye M, et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg. 2005;15:11-23.
13. Wang TN, Huang MC, Chang WT, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14:183-187.
14. Hinuy HM, Hirata MH, Forti N, et al. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq Bras Endocrinol Metabol. 2008;52:611-616.
15. Ben Ali S, Kallel A, Ftouhi B, et al. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin Biochem. 2009;42:584-588.
16. Yiannakouris N, Yannakoulia M, Melistas L, et al. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab. 2001;86:4434-4439.
17. Portoles O, Sorli JV, Frances F, et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol. 2006;21:605-612.
18. Duarte SF, Francischetti EA, Genelhu VA, et al. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G.A gene variants in obese Brazilian subjects. Genet Mol Res. 2007;6:1035-1043.
19. Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-1185.
20. Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270: 26746-26749.
21. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79-83.
22. Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000;20:1595-1599.
23. Rodriguez-Novoa S, Barreiro P, Jimenez-Nacher I, et al. Overview of the pharmacogenetics of HIV therapy. Pharmacogenomics J. 2006;6:234-245.
24. Dabis F, Balestre E, Braitstein P, et al. Cohort profile: antiretroviral therapy in lower income countries (ART-LINC): international collaboration of treatment cohorts. Int J Epidemiol. 2005;34:979-986.
25. Carr A, Emery S, Law M, et al. An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet. 2003; 361:726-735.
26. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
27. Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991;19:5444.
28. Mammes O, Betoulle D, Aubert R, et al. Novel polymorphisms in the 5# region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes. 1998;47:487-489.
29. Matsuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia. 1997;40:1204-1210.
30. Barros AJ, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003;3:21.
31. Multiple Locus Haplotype Analysis. [computer program] Version 2.0. Bethesda, MD: NIAAA, National Institutes of Health 1999.
32. Long JC, Williams RC, Urbanek M. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet. 1995;56:799-810.
33. Tregouet DA, Garelle V. A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinfor-matics. 2007;23:1038-1039.
34. Zembrzuski VM, Callegari-Jacques SM, Hutz MH. Application of an African Ancestry Index as a genomic control approach in a Brazilian population. Ann Hum Genet. 2006;70:822-828.
35. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487-1495.
36. Vasseur F, Helbecque N, Lobbens S, et al. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia. 2005;48:892-899.
37. Genelhu VA, Celoria BM, Pimentel MM, et al. Association of a common variant of the leptin gene with blood pressure in an obese Brazilian population. Am J Hypertens. 2009;22:577-580.
38. Nagy GS, Tsiodras S, Martin LD, et al. Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin. Clin Infect Dis. 2003;36:795-802.
39. Johnson JA, Albu JB, Engelson ES, et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab. 2004;286:E261-E271.
40. Lee JH, Chan JL, Sourlas E, et al. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab. 2006;91: 2605-2611.
41. Kosmiski LA, Bacchetti P, Kotler DP, et al. Relationship of fat distribution with adipokines in human immunodeficiency virus infection. J Clin Endocrinol Metab. 2008;93:216-224.
42. Vasseur F, Helbecque N, Dina C, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11:2607-2614.
43. Bouatia-Naji N, Meyre D, Lobbens S, et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 2006;55:545-550.
44. Kyriakou T, Collins LJ, Spencer-Jones NJ, et al. Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet. 2008;53: 718-727.
45. Schwarz PE, Towers GW, Fischer S, et al. Hypoadiponectinemia is associated with progression toward type 2 diabetes and genetic variation in the ADIPOQ gene promoter. Diabetes Care. 2006;29:1645-1650.
46. Petrone A, Zavarella S, Caiazzo A, et al. The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring). 2006;14:1498-1504.
47. Heid IM, Wagner SA, Gohlke H, et al. Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes. 2006;55: 375-384.
48. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Diabetes Obes Metab. 2007;9:282-289.
49. Delporte ML, Brichard SM, Hermans MP, et al. Hyperadiponectinaemia in anorexia nervosa. Clin Endocrinol (Oxf). 2003;58:22-29.
50. Savage DB, Tan GD, Acerini CL, et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes. 2003;52:910-917.
51. Wong SP, Huda M, English P, et al. Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C. Diabetologia. 2005;48:2641-2649.