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Volumn 7, Issue 4, 2012, Pages 709-721

Spiro[chromane-2,4′-piperidine]-Based Histone Deacetylase Inhibitors with Improved invivo Activity

(16) Thaler, Florian a,b Varasi, Mario b,c Carenzi, Giacomo b,c Colombo, Andrea d Abate, Agnese b,c Bigogno, Chiara d Boggio, Roberto a,e Carrara, Simone d Cataudella, Tiziana c,f DalZuffo, Roberto b,c Reali, Veronica d Vultaggio, Stefania b,c Dondio, Giulio d Gagliardi, Stefania d Minucci, Saverio b,g Mercurio, Ciro c

a Genextra Group (Italy)

b EUROPEAN INSTITUTE OF ONCOLOGY (Italy)

c Genextra Group (Italy)

d NiKem Research (Italy)

e NERVIANO MEDICAL SCIENCES (Italy)

f SAN RAFFAELE HOSPITAL (Italy)

g UNIVERSITY OF MILAN (Italy)

Author keywords

Antiproliferation; Histone deacetylases; Hydroxamates; In vivo activity; Pharmacokinetics

Indexed keywords

BELINOSTAT; HISTONE DEACETYLASE INHIBITOR; PANOBINOSTAT; ROMIDEPSIN; SPIRO(CHROMANE 2,4' PIPERIDINE)DERIVATIVE; SPIROPIPERIDINE; UNCLASSIFIED DRUG; VORINOSTAT;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG HALF LIFE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; HISTONE DEACETYLASE INHIBITORS; INJECTIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859203567 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201200024 Document Type: Article

Times cited : (12)

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