Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system

PLoS Genetics

Volumn 8, Issue 2, 2012, Pages

  Eade, Kevin T ^a   Fancher, Hailey A ^a   Ridyard, Marc S ^a   Allan, Douglas W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FMRFA; TRANSCRIPTION FACTOR NPLP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TYPE; DROSOPHILA; GENE EXPRESSION PROFILING; GENE SILENCING; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN PROCESSING; TRANSCRIPTION REGULATION;

AGING; ANIMALS; CELL DIFFERENTIATION; DROSOPHILA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; NEURONS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84859166155     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002501     Document Type: Article

References (53)

1. Di Sanguinetto SA, Dasen JS, Arber S, (2008) Transcriptional mechanisms controlling motor neuron diversity and connectivity. Curr Opin Neurobiol 18: 36-43.
2. Landgraf M, Thor S, (2006) Development of Drosophila motoneurons: specification and morphology. Semin Cell Dev Biol 17: 3-11.
3. Hobert O, (2010) Neurogenesis in the nematode Caenorhabditis elegans. WormBook pp. 1-24.
4. Hobert O, Carrera I, Stefanakis N, (2010) The molecular and gene regulatory signature of a neuron. Trends Neurosci 33: 435-445.
5. Alavian KN, Scholz C, Simon HH, (2008) Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord 23: 319-328.
6. Baumgardt M, Karlsson D, Terriente J, Diaz-Benjumea FJ, Thor S, (2009) Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. Cell 139: 969-982.
7. Habener JF, Kemp DM, Thomas MK, (2005) Minireview: transcriptional regulation in pancreatic development. Endocrinology 146: 1025-1034.
8. Karlsson D, Baumgardt M, Thor S, (2010) Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. PLoS Biol 8: e1000368 doi:10.1371/journal.pbio.1000368.
9. Baumgardt M, Miguel-Aliaga I, Karlsson D, Ekman H, Thor S, (2007) Specification of neuronal identities by feedforward combinatorial coding. PLoS Biol 5: e37 doi:10.1371/journal.pbio.0050037.
10. Allan DW, Park D, St Pierre SE, Taghert PH, Thor S, (2005) Regulators acting in combinatorial codes also act independently in single differentiating neurons. Neuron 45: 689-700.
11. Miguel-Aliaga I, Allan DW, Thor S, (2004) Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. Development 131: 5837-5848.
12. Allan DW, St Pierre SE, Miguel-Aliaga I, Thor S, (2003) Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113: 73-86.
13. Karlsson D, Baumgardt M, Thor S, Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. PLoS Biol 8: e1000368 doi:10.1371/journal.pbio.1000368.
14. Eade KT, Allan DW, (2009) Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling. J Neurosci 29: 3852-3864.
15. Brody T, Odenwald WF, (2005) Regulation of temporal identities during Drosophila neuroblast lineage development. Curr Opin Cell Biol 17: 672-675.
16. Terriente Felix J, Magarinos M, Diaz-Benjumea FJ, (2007) Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development. Development 134: 1845-1852.
17. Benveniste RJ, Thor S, Thomas JB, Taghert PH, (1998) Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125: 4757-4765.
18. Hewes RS, Park D, Gauthier SA, Schaefer AM, Taghert PH, (2003) The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila. Development 130: 1771-1781.
19. Marques G, Haerry TE, Crotty ML, Xue M, Zhang B, et al. (2003) Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila. Development 130: 5457-5470.
20. Park D, Shafer OT, Shepherd SP, Suh H, Trigg JS, et al. (2008) The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Mol Cell Biol 28: 410-421.
21. Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156.
22. McGuire SE, Mao Z, Davis RL, (2004) Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci STKE 2004: pl6.
23. O'Keefe DD, Thor S, Thomas JB, (1998) Function and specificity of LIM domains in Drosophila nervous system and wing development. Development 125: 3915-3923.
24. Butterworth FM, King RC, (1965) The developmental genetics of apterous mutants of Drosophila melanogaster. Genetics 52: 1153-1174.
25. Hewes RS, Gu T, Brewster JA, Qu C, Zhao T, (2006) Regulation of secretory protein expression in mature cells by DIMM, a basic helix-loop-helix neuroendocrine differentiation factor. J Neurosci 26: 7860-7869.
26. Blau HM, Baltimore D, (1991) Differentiation requires continuous regulation. J Cell Biol 112: 781-783.
27. Etchberger JF, Lorch A, Sleumer MC, Zapf R, Jones SJ, et al. (2007) The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Genes Dev 21: 1653-1674.
28. Flames N, Hobert O, (2009) Gene regulatory logic of dopamine neuron differentiation. Nature 458: 885-889.
29. Schmidt M, Lin S, Pape M, Ernsberger U, Stanke M, et al. (2009) The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons. Dev Biol 329: 191-200.
30. Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, et al. (2010) Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci 13: 1190-1198.
31. Song NN, Xiu JB, Huang Y, Chen JY, Zhang L, et al. (2011) Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PLoS ONE 6: e15998 doi:10.1371/journal.pone.0015998.
32. Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, et al. (2009) Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci 29: 15923-15932.
33. Hobert O, (2011) Maintaining a memory by transcriptional autoregulation. Curr Biol 21: R146-147.
34. Etchberger JF, Flowers EB, Poole RJ, Bashllari E, Hobert O, (2009) Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegans. Development 136: 147-160.
35. Bertrand V, Hobert O, (2009) Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans. Dev Cell 16: 563-575.
36. Lundgren SE, Callahan CA, Thor S, Thomas JB, (1995) Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous. Development 121: 1769-1773.
37. Mihaly J, Barges S, Sipos L, Maeda R, Cleard F, et al. (2006) Dissecting the regulatory landscape of the Abd-B gene of the bithorax complex. Development 133: 2983-2993.
38. Breen TR, Chinwalla V, Harte PJ, (1995) Trithorax is required to maintain engrailed expression in a subset of engrailed-expressing cells. Mech Dev 52: 89-98.
39. Ptashne M, (2007) On the use of the word 'epigenetic'. Curr Biol 17: R233-236.
40. Xu P, Van Slambrouck C, Berti-Mattera L, Hall AK, (2005) Activin induces tactile allodynia and increases calcitonin gene-related peptide after peripheral inflammation. J Neurosci 25: 9227-9235.
41. Sprecher SG, Desplan C, (2008) Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons. Nature 454: 533-537.
42. Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, et al. (2004) Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature 429: 523-530.
43. Grimes DA, Han F, Panisset M, Racacho L, Xiao F, et al. (2006) Translated mutation in the Nurr1 gene as a cause for Parkinson's disease. Mov Disord 21: 906-909.
44. Le W, Pan T, Huang M, Xu P, Xie W, et al. (2008) Decreased NURR1 gene expression in patients with Parkinson's disease. J Neurol Sci 273: 29-33.
45. Kittappa R, Chang WW, Awatramani RB, McKay RD, (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5: e325 doi:10.1371/journal.pbio.0050325.
46. Holland AM, Gonez LJ, Naselli G, Macdonald RJ, Harrison LC, (2005) Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes 54: 2586-2595.
47. Lottmann H, Vanselow J, Hessabi B, Walther R, (2001) The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells. J Mol Med 79: 321-328.
48. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H, (1998) beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 12: 1763-1768.
49. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, et al. (1999) Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 23: 323-328.
50. Gu C, Stein GH, Pan N, Goebbels S, Hornberg H, et al. (2010) Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab 11: 298-310.
51. Heanue TA, Reshef R, Davis RJ, Mardon G, Oliver G, et al. (1999) Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev 13: 3231-3243.
52. Mardon G, Solomon NM, Rubin GM, (1994) dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120: 3473-3486.
53. Pignoni F, Hu B, Zavitz KH, Xiao J, Garrity PA, et al. (1997) The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91: 881-891.