Adult raphe-specific deletion of Lmx1B leads to central serotonin deficiency

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Song, Ning Ning ^a   Xiu, Jian Bo ^a   Huang, Ying ^a   Chen, Jia Yin ^a   Zhang, Lei ^a   Gutknecht, Lise ^b   Lesch, Klaus Peter ^b   Li, He ^c   Ding, Yu Qiang ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DECARBOXYLASE; CRE RECOMBINASE; DOPAMINE; NORADRENALIN; SEROTONIN; SEROTONIN TRANSPORTER; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LMX1B; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; HOMEODOMAIN PROTEIN; LIM HOMEOBOX TRANSCRIPTION FACTOR 1 BETA; SLC18A2 PROTEIN, MOUSE; SLC6A4 PROTEIN, MOUSE; TAMOXIFEN; TPH2 PROTEIN, MOUSE; TRYPTOPHAN HYDROXYLASE; VESICULAR MONOAMINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CENTRAL SEROTONIN DEFICIENCY; CODON; CONTROLLED STUDY; DOWN REGULATION; EMBRYO DEVELOPMENT; GENE DELETION; GENE EXPRESSION REGULATION; GENOTYPE; HOMOLOGOUS RECOMBINATION; HORMONE DEFICIENCY; IMMUNOFLUORESCENCE TEST; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAPHE NUCLEUS; SEROTONIN BLOOD LEVEL; TRANSGENE; AGE; ANIMAL; BIOSYNTHESIS; BRAIN; DRUG EFFECT; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY;

MUS;

AGE FACTORS; ANIMALS; BRAIN; GENE DELETION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MICE; NEURONS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TAMOXIFEN; TRANSCRIPTION FACTORS; TRYPTOPHAN HYDROXYLASE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 79251563127     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015998     Document Type: Article

References (34)

1. Lowry CA, Hale MW, Evans AK, Heerkens J, Staub DR, et al. (2008) Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Ann N Y Acad Sci 1148: 86-94.
2. Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165-229.
3. Cordes SP (2005) Molecular genetics of the early development of hindbrain serotonergic neurons. Clin Genet 68: 487-494.
4. Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, et al. (2003) Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37: 233-247.
5. Dai JX, Han HL, Tian M, Cao J, Xiu JB, et al. (2008) Enhanced contextual fear memory in central serotonin-deficient mice. Proc Natl Acad Sci U S A 105: 11981-11986.
6. Ye W, Shimamura K, Rubenstein JL, Hynes MA, Rosenthal A (1998) FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93: 755-766.
7. Pattyn A, Simplicio N, van Doorninck JH, Goridis C, Guillemot F, et al. (2004) Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci 7: 589-595.
8. Craven SE, Lim KC, Ye W, Engel JD, de Sauvage F, et al. (2004) Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development 131: 1165-1173.
9. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, et al. (1999) Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398: 622-627.
10. van Doorninck JH, van Der Wees J, Karis A, Goedknegt E, Engel JD, et al. (1999) GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. J Neurosci 19: RC12.
11. Cheng L, Chen CL, Luo P, Tan M, Qiu M, et al. (2003) Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci 23: 9961-9967.
12. Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, et al. (2003) Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci 6: 933-938.
13. Young P, Qiu L, Wang D, Zhao S, Gross J, et al. (2008) Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat Neurosci 11: 721-728.
14. Guo C, Qiu HY, Huang Y, Chen H, Yang RQ, et al. (2007) Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 134: 317-325.
15. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71.
16. Scott MM, Wylie CJ, Lerch JK, Murphy R, Lobur K, et al. (2005) A genetic approach to access serotonin neurons for in vivo and in vitro studies. Proc Natl Acad Sci U S A 102: 16472-16477.
17. Dai JX, Hu ZL, Shi M, Guo C, Ding YQ (2008) Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system. J Comp Neurol 509: 341-355.
18. Gutknecht L, Waider J, Kraft S, Kriegebaum C, Holtmann B, et al. (2008) Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm 115: 1127-1132.
19. Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch KP (2009) Spatiotemporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol 19: 266-282.
20. Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates. San Diego: Academic Press, xxv, 1 v. (various pagings).
21. Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305: 217.
22. Blakely RD, Berson HE, Fremeau RT, Jr., Caron MG, Peek MM, et al. (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature 354: 66-70.
23. Fon EA, Pothos EN, Sun BC, Killeen N, Sulzer D, et al. (1997) Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron 19: 1271-1283.
24. Koed K, Linnet K (2000) Opposing changes in serotonin and norepinephrine transporter mRNA levels after serotonin depletion. Eur Neuropsychopharmacol 10: 501-509.
25. Armstrong DM, Ross CA, Pickel VM, Joh TH, Reis DJ (1982) Distribution of dopamine-, noradrenaline-, and adrenaline-containing cell bodies in the rat medulla oblongata: demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes. J Comp Neurol 212: 173-187.
26. Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, et al. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci 26:12781-12788.
27. Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, et al. (2010) Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci 13: 1190-1198.
28. Middlemiss DN, Price GW, Watson JM (2002) Serotonergic targets in depression. Curr Opin Pharmacol 2: 18-22.
29. Coppen A (1967) The biochemistry of affective disorders. Br J Psychiatry 113: 1237-1264.
30. Naughton M, Mulrooney JB, Leonard BE (2000) A review of the role of serotonin receptors in psychiatric disorders. Hum Psychopharmacol 15: 397-415.
31. Bonnin A, Torii M, Wang L, Rakic P, Levitt P (2007) Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 10: 588-597.
32. Yan W, Wilson CC, Haring JH (1997) 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain Res Dev Brain Res 98: 185-190.
33. Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002-1012.
34. Carlen M, Meletis K, Goritz C, Darsalia V, Evergren E, et al. (2009) Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 12: 259-267.