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Volumn 1821, Issue 5, 2012, Pages 826-832

Pathophysiology of hypertriglyceridemia

Author keywords

Cardiovascular disease; GPIHBP1; LMF1; LPL; Triglyceride

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN A5; APOLIPOPROTEIN B48; APOLIPOPROTEIN C2; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; CD36 ANTIGEN; CHYLOMICRON; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; SYNDECAN 1; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84859160168     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.11.010     Document Type: Review
Times cited : (59)

References (59)
  • 1
    • 66149183176 scopus 로고    scopus 로고
    • Disorders of lipoprotein metabolism
    • A.S. Fauci, D.L. Kasper, D.L. Longo, E. Braunwald, S.L. Hauser, J.L. Jameson, J. Loscalzo, McGraw Hill New York
    • D.J. Rader, and H.H. Hobbs Disorders of lipoprotein metabolism A.S. Fauci, D.L. Kasper, D.L. Longo, E. Braunwald, S.L. Hauser, J.L. Jameson, J. Loscalzo, Harrison's Principles of Internal Medicine 2008 McGraw Hill New York 2416 2429
    • (2008) Harrison's Principles of Internal Medicine , pp. 2416-2429
    • Rader, D.J.1    Hobbs, H.H.2
  • 3
    • 55849135236 scopus 로고    scopus 로고
    • Molecular processes that handle - And mishandle - Dietary lipids
    • K.J. Williams Molecular processes that handle - and mishandle - dietary lipids J. Clin. Invest. 118 2008 3247 3259
    • (2008) J. Clin. Invest. , vol.118 , pp. 3247-3259
    • Williams, K.J.1
  • 6
    • 58149457426 scopus 로고    scopus 로고
    • Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
    • C.L. Yen, S.J. Stone, S. Koliwad, C. Harris, and R.V. Farese Jr. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis J. Lipid Res. 49 2008 2283 2301
    • (2008) J. Lipid Res. , vol.49 , pp. 2283-2301
    • Yen, C.L.1    Stone, S.J.2    Koliwad, S.3    Harris, C.4    Farese, Jr.R.V.5
  • 7
    • 80054113117 scopus 로고    scopus 로고
    • Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: Implications for classification and disease risk
    • S. Calandra, P. Tarugi, H.E. Speedy, A.F. Dean, S. Bertolini, and C.C. Shoulders Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk J. Lipid Res. 52 2011 1885 1926
    • (2011) J. Lipid Res. , vol.52 , pp. 1885-1926
    • Calandra, S.1    Tarugi, P.2    Speedy, H.E.3    Dean, A.F.4    Bertolini, S.5    Shoulders, C.C.6
  • 9
    • 77955267226 scopus 로고    scopus 로고
    • Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes
    • B. Verges Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes Atherosclerosis 211 2010 353 360
    • (2010) Atherosclerosis , vol.211 , pp. 353-360
    • Verges, B.1
  • 11
    • 2542499183 scopus 로고    scopus 로고
    • Atorvastatin decreases apolipoprotein C-III in apolipoprotein B-containing lipoprotein and HDL in type 2 diabetes: A potential mechanism to lower plasma triglycerides
    • G.M. Dallinga-Thie, P. Berk II, A.H. Bootsma, and H. Jansen Atorvastatin decreases apolipoprotein C-III in apolipoprotein B-containing lipoprotein and HDL in type 2 diabetes: a potential mechanism to lower plasma triglycerides Diabetes Care 27 2004 1358 1364
    • (2004) Diabetes Care , vol.27 , pp. 1358-1364
    • Dallinga-Thie, G.M.1    Berk, I.I.P.2    Bootsma, A.H.3    Jansen, H.4
  • 12
    • 0026443622 scopus 로고
    • Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo e on the particles
    • K. Aalto-Setala, E.A. Fisher, X. Chen, T. Chajek-Shaul, T. Hayek, R. Zechner, A. Walsh, R. Ramakrishnan, H.N. Ginsberg, and J.L. Breslow Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles J. Clin. Invest. 90 1992 1889 1900
    • (1992) J. Clin. Invest. , vol.90 , pp. 1889-1900
    • Aalto-Setala, K.1    Fisher, E.A.2    Chen, X.3    Chajek-Shaul, T.4    Hayek, T.5    Zechner, R.6    Walsh, A.7    Ramakrishnan, R.8    Ginsberg, H.N.9    Breslow, J.L.10
  • 13
    • 78650401291 scopus 로고    scopus 로고
    • Congenital disorders of glycosylation
    • J. Jaeken Congenital disorders of glycosylation Ann. N. Y. Acad. Sci. 1214 2010 190 198
    • (2010) Ann. N. Y. Acad. Sci. , vol.1214 , pp. 190-198
    • Jaeken, J.1
  • 16
    • 20144375048 scopus 로고    scopus 로고
    • Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    • M. Merkel, B. Loeffler, M. Kluger, N. Fabig, G. Geppert, L.A. Pennacchio, A. Laatsch, and J. Heeren Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase J. Biol. Chem. 280 2005 21553 21560
    • (2005) J. Biol. Chem. , vol.280 , pp. 21553-21560
    • Merkel, M.1    Loeffler, B.2    Kluger, M.3    Fabig, N.4    Geppert, G.5    Pennacchio, L.A.6    Laatsch, A.7    Heeren, J.8
  • 17
    • 77649336543 scopus 로고    scopus 로고
    • Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation
    • X. Shu, L. Nelbach, R.O. Ryan, and T.M. Forte Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation Biochim. Biophys. Acta 1801 2010 605 608
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 605-608
    • Shu, X.1    Nelbach, L.2    Ryan, R.O.3    Forte, T.M.4
  • 18
    • 79956050306 scopus 로고    scopus 로고
    • Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway
    • E.A. Fisher, N.A. Khanna, and R.S. McLeod Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway J. Lipid Res. 52 2011 1170 1180
    • (2011) J. Lipid Res. , vol.52 , pp. 1170-1180
    • Fisher, E.A.1    Khanna, N.A.2    McLeod, R.S.3
  • 20
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • M. Adiels, S.O. Olofsson, M.R. Taskinen, and J. Boren Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome Arterioscler. Thromb. Vasc. Biol. 28 2008 1225 1236
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Boren, J.4
  • 25
    • 77957167810 scopus 로고    scopus 로고
    • Revitalizing membrane rafts: New tools and insights
    • K. Simons, and M.J. Gerl Revitalizing membrane rafts: new tools and insights Nat. Rev. Mol. Cell Biol. 11 2010 688 699
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 688-699
    • Simons, K.1    Gerl, M.J.2
  • 33
    • 1042268030 scopus 로고    scopus 로고
    • Hepatic catabolism of remnant lipoproteins: Where the action is
    • R.J. Havel, and R.L. Hamilton Hepatic catabolism of remnant lipoproteins: where the action is Arterioscler. Thromb. Vasc. Biol. 24 2004 213 215
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 213-215
    • Havel, R.J.1    Hamilton, R.L.2
  • 34
    • 34247610845 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycans fine-tune mammalian physiology
    • J.R. Bishop, M. Schuksz, and J.D. Esko Heparan sulphate proteoglycans fine-tune mammalian physiology Nature 446 2007 1030 1037
    • (2007) Nature , vol.446 , pp. 1030-1037
    • Bishop, J.R.1    Schuksz, M.2    Esko, J.D.3
  • 35
    • 0024579799 scopus 로고
    • Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake
    • R.W. Mahley, D.Y. Hui, T.L. Innerarity, and U. Beisiegel Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake Arteriosclerosis 9 1989 I14 I18
    • (1989) Arteriosclerosis , vol.9
    • Mahley, R.W.1    Hui, D.Y.2    Innerarity, T.L.3    Beisiegel, U.4
  • 36
    • 0032895028 scopus 로고    scopus 로고
    • Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein e
    • R.W. Mahley, and Z.S. Ji Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E J. Lipid Res. 40 1999 1 16
    • (1999) J. Lipid Res. , vol.40 , pp. 1-16
    • Mahley, R.W.1    Ji, Z.S.2
  • 37
    • 0020401918 scopus 로고
    • Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits
    • T. Kita, M.S. Brown, D.W. Bilheimer, and J.L. Goldstein Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits Proc. Natl. Acad. Sci. U. S. A. 79 1982 5693 5697
    • (1982) Proc. Natl. Acad. Sci. U. S. A. , vol.79 , pp. 5693-5697
    • Kita, T.1    Brown, M.S.2    Bilheimer, D.W.3    Goldstein, J.L.4
  • 38
    • 0025095799 scopus 로고
    • Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects
    • D.C. Rubinsztein, J.C. Cohen, G.M. Berger, D.R. van der Westhuyzen, G.A. Coetzee, and W. Gevers Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects J. Clin. Invest. 86 1990 1306 1312
    • (1990) J. Clin. Invest. , vol.86 , pp. 1306-1312
    • Rubinsztein, D.C.1    Cohen, J.C.2    Berger, G.M.3    Van Der Westhuyzen, D.R.4    Coetzee, G.A.5    Gevers, W.6
  • 39
    • 0024449363 scopus 로고
    • The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein
    • U. Beisiegel, W. Weber, G. Ihrke, J. Herz, and K.K. Stanley The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein Nature 341 1989 162 164
    • (1989) Nature , vol.341 , pp. 162-164
    • Beisiegel, U.1    Weber, W.2    Ihrke, G.3    Herz, J.4    Stanley, K.K.5
  • 40
    • 0032004972 scopus 로고    scopus 로고
    • Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
    • A. Rohlmann, M. Gotthardt, R.E. Hammer, and J. Herz Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants J. Clin. Invest. 101 1998 689 695
    • (1998) J. Clin. Invest. , vol.101 , pp. 689-695
    • Rohlmann, A.1    Gotthardt, M.2    Hammer, R.E.3    Herz, J.4
  • 41
    • 33846007667 scopus 로고    scopus 로고
    • Atherogenic remnant lipoproteins: Role for proteoglycans in trapping, transferring, and internalizing
    • R.W. Mahley, and Y. Huang Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing J. Clin. Invest. 117 2007 94 98
    • (2007) J. Clin. Invest. , vol.117 , pp. 94-98
    • Mahley, R.W.1    Huang, Y.2
  • 42
    • 0028913217 scopus 로고
    • Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: In vivo role of heparan sulfate proteoglycans
    • Z.S. Ji, D.A. Sanan, and R.W. Mahley Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans J. Lipid Res. 36 1995 583 592
    • (1995) J. Lipid Res. , vol.36 , pp. 583-592
    • Ji, Z.S.1    Sanan, D.A.2    Mahley, R.W.3
  • 43
    • 70449408083 scopus 로고    scopus 로고
    • Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
    • K.I. Stanford, J.R. Bishop, E.M. Foley, J.C. Gonzales, I.R. Niesman, J.L. Witztum, and J.D. Esko Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice J. Clin. Invest. 119 2009 3236 3245
    • (2009) J. Clin. Invest. , vol.119 , pp. 3236-3245
    • Stanford, K.I.1    Bishop, J.R.2    Foley, E.M.3    Gonzales, J.C.4    Niesman, I.R.5    Witztum, J.L.6    Esko, J.D.7
  • 45
    • 77958198666 scopus 로고    scopus 로고
    • Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins
    • E.M. Foley, and J.D. Esko Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins Prog. Mol. Biol. Transl. Sci. 93 2010 213 233
    • (2010) Prog. Mol. Biol. Transl. Sci. , vol.93 , pp. 213-233
    • Foley, E.M.1    Esko, J.D.2
  • 46
    • 77951996101 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate
    • J.R. Bishop, E. Foley, R. Lawrence, and J.D. Esko Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate J. Biol. Chem. 285 2010 14658 14662
    • (2010) J. Biol. Chem. , vol.285 , pp. 14658-14662
    • Bishop, J.R.1    Foley, E.2    Lawrence, R.3    Esko, J.D.4
  • 47
    • 33846012847 scopus 로고    scopus 로고
    • Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
    • J.M. MacArthur, J.R. Bishop, K.I. Stanford, L. Wang, A. Bensadoun, J.L. Witztum, and J.D. Esko Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members J. Clin. Invest. 117 2007 153 164
    • (2007) J. Clin. Invest. , vol.117 , pp. 153-164
    • MacArthur, J.M.1    Bishop, J.R.2    Stanford, K.I.3    Wang, L.4    Bensadoun, A.5    Witztum, J.L.6    Esko, J.D.7
  • 49
    • 48249099359 scopus 로고    scopus 로고
    • Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
    • I.J. Goldberg, Y. Hu, H.L. Noh, J. Wei, L.A. Huggins, M.G. Rackmill, H. Hamai, B.N. Reid, W.S. Blaner, and L.S. Huang Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes Diabetes 57 2008 1674 1682
    • (2008) Diabetes , vol.57 , pp. 1674-1682
    • Goldberg, I.J.1    Hu, Y.2    Noh, H.L.3    Wei, J.4    Huggins, L.A.5    Rackmill, M.G.6    Hamai, H.7    Reid, B.N.8    Blaner, W.S.9    Huang, L.S.10
  • 50
    • 0037147259 scopus 로고    scopus 로고
    • Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans
    • M. Morimoto-Tomita, K. Uchimura, Z. Werb, S. Hemmerich, and S.D. Rosen Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans J. Biol. Chem. 277 2002 49175 49185
    • (2002) J. Biol. Chem. , vol.277 , pp. 49175-49185
    • Morimoto-Tomita, M.1    Uchimura, K.2    Werb, Z.3    Hemmerich, S.4    Rosen, S.D.5
  • 51
    • 78649565048 scopus 로고    scopus 로고
    • Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins
    • K. Chen, M.L. Liu, L. Schaffer, M. Li, G. Boden, X. Wu, and K.J. Williams Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins Hepatology 52 2010 1957 1967
    • (2010) Hepatology , vol.52 , pp. 1957-1967
    • Chen, K.1    Liu, M.L.2    Schaffer, L.3    Li, M.4    Boden, G.5    Wu, X.6    Williams, K.J.7
  • 52
    • 79953692987 scopus 로고    scopus 로고
    • Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice
    • D. Planer, S. Metzger, E. Zcharia, I.D. Wexler, I. Vlodavsky, and T. Chajek-Shaul Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice PLoS One 6 2011 e18370
    • (2011) PLoS One , vol.6 , pp. 18370
    • Planer, D.1    Metzger, S.2    Zcharia, E.3    Wexler, I.D.4    Vlodavsky, I.5    Chajek-Shaul, T.6
  • 53
    • 33748674433 scopus 로고    scopus 로고
    • Unraveling the complex genetics of familial combined hyperlipidemia
    • E. Suviolahti, H.E. Lilja, and P. Pajukanta Unraveling the complex genetics of familial combined hyperlipidemia Ann. Med. 38 2006 337 351
    • (2006) Ann. Med. , vol.38 , pp. 337-351
    • Suviolahti, E.1    Lilja, H.E.2    Pajukanta, P.3
  • 54
    • 66349102249 scopus 로고    scopus 로고
    • New technologies for delineating and characterizing the lipid exome: Prospects for understanding familial combined hyperlipidemia
    • S.D. Horswell, H.E. Ringham, and C.C. Shoulders New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia J. Lipid Res. 50 Suppl 2009 S370 S375
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Horswell, S.D.1    Ringham, H.E.2    Shoulders, C.C.3
  • 56
    • 79960644031 scopus 로고    scopus 로고
    • Genetic bases of hypertriglyceridemic phenotypes
    • C.T. Johansen, and R.A. Hegele Genetic bases of hypertriglyceridemic phenotypes Curr. Opin. Lipidol. 22 2011 247 253
    • (2011) Curr. Opin. Lipidol. , vol.22 , pp. 247-253
    • Johansen, C.T.1    Hegele, R.A.2
  • 57
    • 0032515775 scopus 로고    scopus 로고
    • Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
    • R.C. Turner, H. Millns, H.A. Neil, I.M. Stratton, S.E. Manley, D.R. Matthews, and R.R. Holman Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23) BMJ 316 1998 823 828
    • (1998) BMJ , vol.316 , pp. 823-828
    • Turner, R.C.1    Millns, H.2    Neil, H.A.3    Stratton, I.M.4    Manley, S.E.5    Matthews, D.R.6    Holman, R.R.7
  • 58
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • B.G. Nordestgaard, M. Benn, P. Schnohr, and A. Tybjaerg-Hansen Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women JAMA 298 2007 299 308
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 59
    • 8344262274 scopus 로고    scopus 로고
    • Arterial permeability and efflux of apolipoprotein B-containing lipoproteins assessed by in situ perfusion and three-dimensional quantitative confocal microscopy
    • S.D. Proctor, D.F. Vine, and J.C. Mamo Arterial permeability and efflux of apolipoprotein B-containing lipoproteins assessed by in situ perfusion and three-dimensional quantitative confocal microscopy Arterioscler. Thromb. Vasc. Biol. 24 2004 2162 2167
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 2162-2167
    • Proctor, S.D.1    Vine, D.F.2    Mamo, J.C.3


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