Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 5, 2010, Pages 605-608

  Shu, Xiao ^a,b   Nelbach, Lisa ^a   Ryan, Robert O ^a,b   Forte, Trudy M ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

APOA5 transgenic mouse; Apolipoprotein A V; Lipid droplet; Liver; Triglyceride

Indexed keywords

APOLIPOPROTEIN A5; FAT DROPLET; HEPARIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; KNOCKOUT MOUSE; LIPOPROTEIN BLOOD LEVEL; LIVER; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; TISSUE LEVEL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; APOLIPOPROTEINS; HEPARIN; INCLUSION BODIES; LIPID METABOLISM; LIVER; MALE; MICE; MICE, TRANSGENIC; TRIGLYCERIDES;

MUS; MUS MUSCULUS;

EID: 77649336543     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.02.004     Document Type: Article

References (21)

1. Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.C., Krauss R.M., and Rubin E.M. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294 (2001) 169-173
2. van der Vliet H.N., Sammels M.G., Leegwater A.C., Levels J.H., Reitsma P.H., Boers W., and Chamuleau R.A. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 276 (2001) 44512-44520
3. Wong K., and Ryan R.O. Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Curr. Opin. Lipidol. 18 (2007) 319-324
4. O'Brien P.J., Alborn W.E., Sloan J.H., Ulmer M., Boodhoo A., Knierman M.D., Schultze A.E., and Konrad R.J. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin. Chem. 51 (2005) 351-359
5. Nelbach L., Shu X., Konrad R.J., Ryan R.O., and Forte T.M. Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice. J. Lipid Res. 49 (2008) 572-580
6. Merkel M., and Heeren J. Give me A5 for lipoprotein hydrolysis!. J. Clin. Invest. 115 (2005) 2694-2696
7. Lookene A., Beckstead J.A., Nilsson S., Olivecrona G., and Ryan R.O. Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J. Biol. Chem. 280 (2005) 25383-25387
8. Nilsson S.K., Lookene A., Beckstead J.A., Gliemann J., Ryan R.O., and Olivecrona G. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 (2007) 3896-3904
9. Merkel M., Loeffler B., Kluger M., Fabig N., Geppert G., Pennacchio L.A., Laatsch A., and Heeren J. Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase. J. Biol. Chem. 280 (2005) 21553-21560
10. Shu X., Chan J., Ryan R.O., and Forte T.M. Apolipoprotein A-V association with intracellular lipid droplets. J. Lipid Res. 48 (2007) 1445-1450
11. Shu X., Ryan R.O., and Forte T.M. Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment. J. Lipid Res. 49 (2008) 1670-1676
12. Beckstead J.A., Oda M.N., Martin D.D., Forte T.M., Bielicki J.K., Berger T., Luty R., Kay C.M., and Ryan R.O. Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis. Biochemistry 42 (2003) 9416-9423
13. Wang H., Gilham D., and Lehner R. Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly. J. Biol. Chem. 282 (2007) 33218-33226
14. Forte T.M., Krauss R.M., Lindgren F.T., and Nichols A.V. Changes in plasma lipoprotein distribution and formation of two unusual particles after heparin-induced lipolysis in hypertriglyceridemic subjects. Proc. Natl. Acad. Sci. U.S.A. 76 (1979) 5934-5938
15. Forte T.M., Shu X., and Ryan R.O. The ins (cell) and outs (plasma) of apolipoprotein A-V. J. Lipid Res. 50 (2009) S150-S155
16. Gin P., Yin L., Davies B.S.J., Weinstein M.M., Ryan R.O., Bensadoun A., Fong L.G., Young S.G., and Beigneux A.P. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J. Biol. Chem. 283 (2008) 29554-29562
17. Martin S., and Parton R.G. Lipid droplets: a unified view of a dynamic organelle. Nat. Rev. Mol. Cell Biol. 7 (2006) 373-378
18. Brasaemle D.L., Barber T., Wolins N.E., Serrero G., Blanchette-Mackie E.J., and Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38 (1997) 2249-2263
19. Ducharme N.A., and Bickel P.E. Minireview: lipid droplets in lipogenesis and lipolysis. Endocrinology 149 (2008) 942-949
20. Weinberg R.B., Cook V.R., Beckstead J.A., Martin D.D., Gallagher J.W., Shelness G.S., and Ryan R.O. Structure and interfacial properties of human apolipoprotein A-V. J. Biol. Chem. 278 (2003) 34438-34444
21. Masuda Y., Itabe H., Odaki M., Hama K., Fujimoto Y., Mori M., Sasabe N., Aoki J., Arai H., and Takano T. ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. J. Lipid Res. 47 (2006) 87-98