메뉴 건너뛰기




Volumn 7, Issue , 2009, Pages

Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN MDM2; PROTEIN P53; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MDM2 PROTEIN, HUMAN;

EID: 74549178441     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-7-110     Document Type: Article
Times cited : (73)

References (40)
  • 1
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • 10.1016/S1470-2045(01)00486-7, 11905707
    • Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001, 2:533-543. 10.1016/S1470-2045(01)00486-7, 11905707.
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 2
    • 0021965806 scopus 로고
    • Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients
    • 10.1002/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E, 2990661
    • Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, Nakajima Y, Ohnishi K. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985, 56:918-928. 10.1002/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E, 2990661.
    • (1985) Cancer , vol.56 , pp. 918-928
    • Okuda, K.1    Ohtsuki, T.2    Obata, H.3    Tomimatsu, M.4    Okazaki, N.5    Hasegawa, H.6    Nakajima, Y.7    Ohnishi, K.8
  • 3
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • 10.1016/S0092-8674(00)81871-1, 9039259
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997, 88:323-331. 10.1016/S0092-8674(00)81871-1, 9039259.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 6
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • 359960, 7686617
    • Chen J, Marechal V, Levine AJ. Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 1993, 13:4107-4114. 359960, 7686617.
    • (1993) Mol Cell Biol , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 7
    • 0031702817 scopus 로고    scopus 로고
    • Regulation of Mdm2-directed degradation by the C terminus of p53
    • 109155, 9742086
    • Kubbutat MH, Ludwig RL, Ashcroft M, Vousden KH. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol Cell Biol 1998, 18:5690-5698. 109155, 9742086.
    • (1998) Mol Cell Biol , vol.18 , pp. 5690-5698
    • Kubbutat, M.H.1    Ludwig, R.L.2    Ashcroft, M.3    Vousden, K.H.4
  • 8
    • 0346455771 scopus 로고    scopus 로고
    • The MDM2-p53 interaction
    • Moll UM, Petrenko O. The MDM2-p53 interaction. Mol Cancer Res 2003, 1:1001-1008.
    • (2003) Mol Cancer Res , vol.1 , pp. 1001-1008
    • Moll, U.M.1    Petrenko, O.2
  • 9
    • 0031948753 scopus 로고    scopus 로고
    • Protein expression of p53, p21WAF1, and Rb as prognostic indicators in patients with surgically treated hepatocellular carcinoma
    • Naka T, Toyota N, Kaneko T, Kaibara N. Protein expression of p53, p21WAF1, and Rb as prognostic indicators in patients with surgically treated hepatocellular carcinoma. Anticancer Res 1998, 18:555-564.
    • (1998) Anticancer Res , vol.18 , pp. 555-564
    • Naka, T.1    Toyota, N.2    Kaneko, T.3    Kaibara, N.4
  • 10
    • 0034869599 scopus 로고    scopus 로고
    • Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis
    • 10.1053/hupa.2001.27105, 11521219
    • Qin LF, Ng IO. Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis. Hum Pathol 2001, 32:778-784. 10.1053/hupa.2001.27105, 11521219.
    • (2001) Hum Pathol , vol.32 , pp. 778-784
    • Qin, L.F.1    Ng, I.O.2
  • 11
    • 14544281476 scopus 로고    scopus 로고
    • Hepatocellular carcinoma--survival and clinical characteristics in relation to various histologic molecular markers in Western patients
    • 10.1111/j.1478-3231.2004.0997.x, 15698400
    • Schoniger-Hekele M, Hanel S, Wrba F, Muller C. Hepatocellular carcinoma--survival and clinical characteristics in relation to various histologic molecular markers in Western patients. Liver Int 2005, 25:62-69. 10.1111/j.1478-3231.2004.0997.x, 15698400.
    • (2005) Liver Int , vol.25 , pp. 62-69
    • Schoniger-Hekele, M.1    Hanel, S.2    Wrba, F.3    Muller, C.4
  • 12
    • 33646538353 scopus 로고    scopus 로고
    • Prognostic significance of p53 overexpression after hepatic resection of hepatocellular carcinoma
    • Sung CO, Yoo BC, Koh KC, Cho JW, Park CK. Prognostic significance of p53 overexpression after hepatic resection of hepatocellular carcinoma. Korean J Gastroenterol 2005, 45:425-430.
    • (2005) Korean J Gastroenterol , vol.45 , pp. 425-430
    • Sung, C.O.1    Yoo, B.C.2    Koh, K.C.3    Cho, J.W.4    Park, C.K.5
  • 13
    • 0031470644 scopus 로고    scopus 로고
    • Prognostic influence of clinicopathologic features, DNA-ploidy, CD44H and p53 expression in a large series of resected hepatocellular carcinoma in France
    • 10.1002/(SICI)1097-0215(19971219)74:6<614::AID-IJC10>3.0.CO;2-5, 9421358
    • Terris B, Laurent-Puig P, Belghitti J, Degott C, Henin D, Flejou JF. Prognostic influence of clinicopathologic features, DNA-ploidy, CD44H and p53 expression in a large series of resected hepatocellular carcinoma in France. Int J Cancer 1997, 74:614-619. 10.1002/(SICI)1097-0215(19971219)74:6<614::AID-IJC10>3.0.CO;2-5, 9421358.
    • (1997) Int J Cancer , vol.74 , pp. 614-619
    • Terris, B.1    Laurent-Puig, P.2    Belghitti, J.3    Degott, C.4    Henin, D.5    Flejou, J.F.6
  • 14
    • 53549085161 scopus 로고    scopus 로고
    • Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients
    • 10.1002/jso.21109, 18646041
    • Tseng PL, Tai MH, Huang CC, Wang CC, Lin JW, Hung CH, Chen CH, Wang JH, Lu SN, Lee CM, et al. Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients. J Surg Oncol 2008, 98(5):349-57. 10.1002/jso.21109, 18646041.
    • (2008) J Surg Oncol , vol.98 , Issue.5 , pp. 349-357
    • Tseng, P.L.1    Tai, M.H.2    Huang, C.C.3    Wang, C.C.4    Lin, J.W.5    Hung, C.H.6    Chen, C.H.7    Wang, J.H.8    Lu, S.N.9    Lee, C.M.10
  • 15
    • 34447309035 scopus 로고    scopus 로고
    • P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection
    • 10.1111/j.1478-3231.2007.01499.x, 17617120
    • Kao JT, Chuah SK, Huang CC, Chen CL, Wang CC, Hung CH, Chen CH, Wang JH, Lu SN, Lee CM, et al. P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection. Liver Int 2007, 27:772-781. 10.1111/j.1478-3231.2007.01499.x, 17617120.
    • (2007) Liver Int , vol.27 , pp. 772-781
    • Kao, J.T.1    Chuah, S.K.2    Huang, C.C.3    Chen, C.L.4    Wang, C.C.5    Hung, C.H.6    Chen, C.H.7    Wang, J.H.8    Lu, S.N.9    Lee, C.M.10
  • 17
    • 33646114053 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
    • 10.1016/j.canlet.2005.05.014, 15990224
    • Miao J, Chen GG, Chun SY, Lai PP. Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression. Cancer Lett 2006, 236:115-124. 10.1016/j.canlet.2005.05.014, 15990224.
    • (2006) Cancer Lett , vol.236 , pp. 115-124
    • Miao, J.1    Chen, G.G.2    Chun, S.Y.3    Lai, P.P.4
  • 19
    • 66149120348 scopus 로고    scopus 로고
    • Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases
    • 10.1186/1471-2407-7-38, 1829164, 17335582
    • Yun JP, Zhang MF, Hou JH, Tian QH, Fu J, Liang XM, Wu QL, Rong TH. Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases. BMC Cancer 2007, 7:38. 10.1186/1471-2407-7-38, 1829164, 17335582.
    • (2007) BMC Cancer , vol.7 , pp. 38
    • Yun, J.P.1    Zhang, M.F.2    Hou, J.H.3    Tian, Q.H.4    Fu, J.5    Liang, X.M.6    Wu, Q.L.7    Rong, T.H.8
  • 20
    • 33947587168 scopus 로고    scopus 로고
    • Prognostic molecular markers in hepatocellular carcinoma: a systematic review
    • 10.1016/j.ejca.2007.01.004, 17291746
    • Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, Berry DP. Prognostic molecular markers in hepatocellular carcinoma: a systematic review. Eur J Cancer 2007, 43:979-992. 10.1016/j.ejca.2007.01.004, 17291746.
    • (2007) Eur J Cancer , vol.43 , pp. 979-992
    • Mann, C.D.1    Neal, C.P.2    Garcea, G.3    Manson, M.M.4    Dennison, A.R.5    Berry, D.P.6
  • 22
    • 0027717617 scopus 로고
    • P21 is a universal inhibitor of cyclin kinases
    • 10.1038/366701a0, 8259214
    • Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993, 366:701-704. 10.1038/366701a0, 8259214.
    • (1993) Nature , vol.366 , pp. 701-704
    • Xiong, Y.1    Hannon, G.J.2    Zhang, H.3    Casso, D.4    Kobayashi, R.5    Beach, D.6
  • 23
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • 10.1016/0092-8674(94)90379-4, 8137420
    • Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994, 76:1013-1023. 10.1016/0092-8674(94)90379-4, 8137420.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 25
    • 0029815820 scopus 로고    scopus 로고
    • Differentiation-associated overexpression of the cyclin-dependent kinase inhibitor p21waf-1 in human cutaneous squamous cell carcinoma
    • 1865206, 8863663
    • Tron VA, Tang L, Yong WP, Trotter MJ. Differentiation-associated overexpression of the cyclin-dependent kinase inhibitor p21waf-1 in human cutaneous squamous cell carcinoma. Am J Pathol 1996, 149:1139-1146. 1865206, 8863663.
    • (1996) Am J Pathol , vol.149 , pp. 1139-1146
    • Tron, V.A.1    Tang, L.2    Yong, W.P.3    Trotter, M.J.4
  • 28
    • 0000389767 scopus 로고    scopus 로고
    • P21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma
    • 10.1002/(SICI)1097-0215(19980821)79:4<424::AID-IJC19>3.0.CO;2-4, 9699537
    • Qin LF, Ng IO, Fan ST, Ng M. p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. Int J Cancer 1998, 79:424-428. 10.1002/(SICI)1097-0215(19980821)79:4<424::AID-IJC19>3.0.CO;2-4, 9699537.
    • (1998) Int J Cancer , vol.79 , pp. 424-428
    • Qin, L.F.1    Ng, I.O.2    Fan, S.T.3    Ng, M.4
  • 29
    • 0031052356 scopus 로고    scopus 로고
    • Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration
    • 10.1002/hep.510250311, 9049198
    • Albrecht JH, Meyer AH, Hu MY. Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration. Hepatology 1997, 25:557-563. 10.1002/hep.510250311, 9049198.
    • (1997) Hepatology , vol.25 , pp. 557-563
    • Albrecht, J.H.1    Meyer, A.H.2    Hu, M.Y.3
  • 31
    • 0036017536 scopus 로고    scopus 로고
    • High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases
    • 10.1053/hupa.2002.124724, 12055678
    • Wagayama H, Shiraki K, Sugimoto K, Ito T, Fujikawa K, Yamanaka T, Takase K, Nakano T. High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. Hum Pathol 2002, 33:429-434. 10.1053/hupa.2002.124724, 12055678.
    • (2002) Hum Pathol , vol.33 , pp. 429-434
    • Wagayama, H.1    Shiraki, K.2    Sugimoto, K.3    Ito, T.4    Fujikawa, K.5    Yamanaka, T.6    Takase, K.7    Nakano, T.8
  • 32
    • 38449114035 scopus 로고    scopus 로고
    • Down-regulation of tumor suppressor gene PTEN, overexpression of p53, plus high proliferating cell nuclear antigen index predict poor patient outcome of hepatocellular carcinoma after resection
    • Hu TH, Wang CC, Huang CC, Chen CL, Hung CH, Chen CH, Wang JH, Lu SN, Lee CM, Changchien CS, et al. Down-regulation of tumor suppressor gene PTEN, overexpression of p53, plus high proliferating cell nuclear antigen index predict poor patient outcome of hepatocellular carcinoma after resection. Oncol Rep 2007, 18:1417-1426.
    • (2007) Oncol Rep , vol.18 , pp. 1417-1426
    • Hu, T.H.1    Wang, C.C.2    Huang, C.C.3    Chen, C.L.4    Hung, C.H.5    Chen, C.H.6    Wang, J.H.7    Lu, S.N.8    Lee, C.M.9    Changchien, C.S.10
  • 33
    • 22944465392 scopus 로고    scopus 로고
    • Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma
    • 10.1080/00016480410023056, 16012042
    • Bandoh N, Hayashi T, Takahara M, Kishibe K, Ogino T, Katayama A, Imada M, Nonaka S, Harabuchi Y. Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. Acta Otolaryngol 2005, 125:779-785. 10.1080/00016480410023056, 16012042.
    • (2005) Acta Otolaryngol , vol.125 , pp. 779-785
    • Bandoh, N.1    Hayashi, T.2    Takahara, M.3    Kishibe, K.4    Ogino, T.5    Katayama, A.6    Imada, M.7    Nonaka, S.8    Harabuchi, Y.9
  • 34
    • 14844322405 scopus 로고    scopus 로고
    • Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival
    • 10.1111/j.1440-1827.2005.01804.x, 15693850
    • Bahnassy AA, Zekri AR, Abdallah S, El-Shehaby AM, Sherif GM. Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival. Pathol Int 2005, 55:53-62. 10.1111/j.1440-1827.2005.01804.x, 15693850.
    • (2005) Pathol Int , vol.55 , pp. 53-62
    • Bahnassy, A.A.1    Zekri, A.R.2    Abdallah, S.3    El-Shehaby, A.M.4    Sherif, G.M.5
  • 36
    • 33645010354 scopus 로고    scopus 로고
    • A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma
    • 10.1111/j.1464-410X.2006.06054.x, 16469041
    • Doganavsargil B, Simsir A, Boyacioglu H, Cal C, Hekimgil M. A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma. BJU Int 2006, 97:644-648. 10.1111/j.1464-410X.2006.06054.x, 16469041.
    • (2006) BJU Int , vol.97 , pp. 644-648
    • Doganavsargil, B.1    Simsir, A.2    Boyacioglu, H.3    Cal, C.4    Hekimgil, M.5
  • 37
  • 39
    • 0034071665 scopus 로고    scopus 로고
    • P21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma
    • 10.1006/gyno.2000.5748, 10785471
    • Schmider A, Gee C, Friedmann W, Lukas JJ, Press MF, Lichtenegger W, Reles A. p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma. Gynecol Oncol 2000, 77:237-242. 10.1006/gyno.2000.5748, 10785471.
    • (2000) Gynecol Oncol , vol.77 , pp. 237-242
    • Schmider, A.1    Gee, C.2    Friedmann, W.3    Lukas, J.J.4    Press, M.F.5    Lichtenegger, W.6    Reles, A.7
  • 40
    • 15544371613 scopus 로고    scopus 로고
    • P53 and mdm2 as prognostic indicators in patients with epithelial ovarian cancer: a multivariate analysis
    • 10.1016/j.ygyno.2004.12.053, 15790436
    • Dogan E, Saygili U, Tuna B, Gol M, Gurel D, Acar B, Koyuncuoglu M. p53 and mdm2 as prognostic indicators in patients with epithelial ovarian cancer: a multivariate analysis. Gynecol Oncol 2005, 97:46-52. 10.1016/j.ygyno.2004.12.053, 15790436.
    • (2005) Gynecol Oncol , vol.97 , pp. 46-52
    • Dogan, E.1    Saygili, U.2    Tuna, B.3    Gol, M.4    Gurel, D.5    Acar, B.6    Koyuncuoglu, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.