Effects of cinacalcet in renal transplant patients with hyperparathyroidism

American Journal of Nephrology

Volumn 35, Issue 4, 2012, Pages 341-348

  Courbebaisse, Marie ^a,b,c   Diet, Carine ^a   Timsit, Marc Olivier ^a   Mamzer, Marie France ^a   Thervet, Eric ^a,c   Noel, Laure Hlne ^a,b   Legendre, Christophe ^a,c   Friedlander, Gérard ^a,b,c,d   Martinez, Frank ^a   Prié, Dominique ^a,b,c  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

Calcimimetics; Calcium; Hypercalciuria; Parathyroid hormone; Phosphate

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; CALCIUM; CINACALCET; CREATININE; CYCLOSPORIN A; FIBROBLAST GROWTH FACTOR 23; FUROSEMIDE; PARATHYROID HORMONE; PHOSPHATE; TACROLIMUS; VITAMIN D;

ADULT; AGED; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CONTROLLED STUDY; CREATININE URINE LEVEL; DISEASE SEVERITY; DRUG EFFECT; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERCALCEMIA; HYPERCALCIURIA; HYPERPARATHYROIDISM; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; URINARY EXCRETION;

ADULT; AGED; BIOPSY; CALCIMIMETIC AGENTS; CALCIUM; CHI-SQUARE DISTRIBUTION; FEMALE; FIBROBLAST GROWTH FACTORS; GLOMERULAR FILTRATION RATE; HUMANS; HYPERCALCIURIA; HYPERPARATHYROIDISM; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; NAPHTHALENES; NEPHROCALCINOSIS; PARATHYROID HORMONE; PHOSPHATES; VITAMIN D; YOUNG ADULT;

EID: 84859152595     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000337526     Document Type: Article

References (38)

1. Lewin E: Involution of the parathyroid glands after renal transplantation. Curr Opin Nephrol Hypertens 2003; 12: 363-371. (Pubitemid 36871859)
2. Gwinner W, Suppa S, Mengel M, Hoy L, Kreipe HH, Haller H, Schwarz A: Early calcification of renal allografts detected by protocol biopsies: causes and clinical implications. Am J Transplant 2005; 5: 1934-1941. (Pubitemid 41039868)
3. Borchhardt K, Sulzbacher I, Benesch T, Fodinger M, Sunder-Plassmann G, Haas M: Low-turnover bone disease in hypercalcemic hyperparathyroidism after kidney transplantation. Am J Transplant 2007; 7: 2515-2521. (Pubitemid 47561599)
4. Evenepoel P, Claes K, Kuypers D, Maes B, Vanrenterghem Y: Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: a single-centre study. Nephrol Dial Transplant 2005; 20: 1714-1720. (Pubitemid 41418599)
5. Garcia A, Mazuecos A, Garcia T, Gonzalez P, Ceballos M, Rivero M: Effect of parathyroidectomy on renal graft function. Transplant Proc 2005; 37: 1459-1461. (Pubitemid 40712082)
6. Lee PP, Schiffmann L, Offermann G, Beige J: Effects of parathyroidectomy on renal allograft survival. Kidney Blood Press Res 2004; 27: 191-196. (Pubitemid 39140432)
7. Rostaing L, Moreau-Gaudry X, Baron E, Cisterne JM, Monrozies-Bernadet P, Durand D: Changes in blood pressure and renal function following subtotal parathyroidectomy in renal transplant patients presenting with persistent hypercalcemic hyperparathyroidism. Clin Nephrol 1997; 47: 248-255. (Pubitemid 27174111)
8. Bonarek H, Merville P, Bonarek M, Moreau K, Morel D, Aparicio M, Potaux L: Reduced parathyroid functional mass after successful kidney transplantation. Kidney Int 1999; 56: 642-649. (Pubitemid 29353163)
9. Torres A, Rodriguez AP, Concepcion MT, Garcia S, Rufino M, Martin B, Perez L, Machado M, de Bonis E, Losada M, Hernandez D, Lorenzo V: Parathyroid function in long-term renal transplant patients: importance of pre-transplant PTH concentrations. Nephrol Dial Transplant 1998; 13(suppl 3):94-97. (Pubitemid 28154354)
10. Nagano N: Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism. Pharmacol Ther 2006; 109: 339-365. (Pubitemid 43132817)
11. Steddon SJ, Cunningham J: Calcimimetics and calcilytics - fooling the calcium receptor. Lancet 2005; 365: 2237-2239. (Pubitemid 40853917)
12. Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drueke TB, Goodman WG: Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004; 350: 1516-1525. (Pubitemid 38477776)
13. Goodman WG: Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol 2003; 18: 1206-1210. (Pubitemid 37527091)
14. Lindberg JS, Culleton B, Wong G, Borah MF, Clark RV, Shapiro WB, Roger SD, Husserl FE, Klassen PS, Guo MD, Albizem MB, Coburn JW: Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, doubleblind, multicenter study. J Am Soc Nephrol 2005; 16: 800-807. (Pubitemid 41725117)
15. Quarles LD: Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism in stage 5 chronic kidney disease. Kidney Int Suppl 2005:S24-S28.
16. Quarles LD, Sherrard DJ, Adler S, Rosansky SJ, McCary LC, Liu W, Turner SA, Bushinsky DA: The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease. J Am Soc Nephrol 2003; 14: 575-583. (Pubitemid 36246000)
17. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D: Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab 2005; 90: 135-141. (Pubitemid 40116646)
18. Shoback DM, Bilezikian JP, Turner SA, Mc- Cary LC, Guo MD, Peacock M: The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. J Clin Endocrinol Metab 2003; 88: 5644-5649. (Pubitemid 38033028)
19. Apostolou T, Kollia K, Damianou L, Kaitsioti H, Kotsiev V, Dracopoulos S, Vougas V, Hadjiconstantinou V: Hypercalcemia due to resistant hyperparathyroidism in renal transplant patients treated with the calcimimetic agent cinacalcet. Transplant Proc 2006; 38: 3514-3516. (Pubitemid 44908511)
20. Kruse AE, Eisenberger U, Frey FJ, Mohaupt MG: The calcimimetic cinacalcet normalizes serum calcium in renal transplant patients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005; 20: 1311-1314. (Pubitemid 41435024)
21. Serra AL, Schwarz AA, Wick FH, Marti HP, Wuthrich RP: Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005; 20: 1315-1319. (Pubitemid 41430604)
22. Szwarc I, Argiles A, Garrigue V, Delmas S, Chong G, Deleuze S, Mourad G: Cinacalcet chloride is efficient and safe in renal transplant recipients with posttransplant hyperparathyroidism. Transplantation 2006; 82: 675-680. (Pubitemid 44395239)
23. Bergua C, Torregrosa JV, Cofan F, Oppenheimer F: Cinacalcet for the treatment of hypercalcemia in renal transplanted patients with secondary hyperparathyroidism. Transplant Proc 2007; 39: 2254-2255. (Pubitemid 47418225)
24. Leca N, Laftavi M, Gundroo A, Kohli R, Min I, Karam J, Sridhar N, Blessios G, Venuto R, Pankewycz O: Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcet. Am J Transplant 2006; 6: 2391-2395. (Pubitemid 44359425)
25. Srinivas TR, Schold JD, Womer KL, Kaplan B, Howard RJ, Bucci CM, Meier-Kriesche HU: Improvement in hypercalcemia with cinacalcet after kidney transplantation. Clin J Am Soc Nephrol 2006; 1: 323-326.
26. El-Amm JM, Doshi MD, Singh A, Migdal S, Morawski K, Sternbauer D, Cincotta E, West MS, Losanoff JE, Gruber SA: Preliminary experience with cinacalcet use in persistent secondary hyperparathyroidism after kidney transplantation. Transplantation 2007; 83: 546-549. (Pubitemid 46440240)
27. Morales E, Gutierrez E, Andres A: Treatment with calcimimetics in kidney transplantation. Transplant Rev (Orlando) 2010; 24: 79-88.
28. Copley JB, Germain M, Stern L, Pankewycz O, Katznelson S, Shah T, Wang O, Turner SA, Sprague SM: Evaluation of cinacalcet HCl treatment after kidney transplantation. Transplant Proc 2010; 42: 2503-2508.
29. Schwarz A, Merkel S, Leitolf H, Haller H: The effect of cinacalcet on bone remodeling and renal function in transplant patients with persistent hyperparathyroidism. Transplantation 2011; 91: 560-565.
30. Seikrit C, Muhlfeld A, Groene HJ, Floege J: Renal allograft failure in a hyperparathyroid patient following initiation of a calcimimetic. Nat Rev Nephrol 2011; 7: 237-241.
31. Peng LW, Logan JL, James SH, Scott KM, Lien YH: Cinacalcet-associated graft dysfunction and nephrocalcinosis in a kidney transplant recipient. Am J Med 2007; 120:e7-e9. (Pubitemid 47313323)
32. Brochner-Mortensen J: A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 1972; 30: 271-274.
33. Cavalier E, Rozet E, Dubois N, Charlier C, Hubert P, Chapelle JP, Krzesinski JM, Delanaye P: Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment. Clin Chim Acta 2008; 396: 80-85.
34. Summerfield AL, Hortin GL, Smith CH, Wilhite TR, Landt M: Automated enzymatic analysis of inulin. Clin Chem 1993; 39: 2333-2337. (Pubitemid 23333332)
35. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DS, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M: Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753-760. (Pubitemid 351347767)
36. Kruse AE, Eisenberger U, Frey FJ, Mohaupt MG: Effect of cinacalcet cessation in renal transplant recipients with persistent hyperparathyroidism. Nephrol Dial Transplant 2007; 22: 2362-2365. (Pubitemid 47244719)
37. Serra AL, Braun SC, Starke A, Savoca R, Hersberger M, Russmann S, Corti N, Wuthrich RP: Pharmacokinetics and pharmacodynamics of cinacalcet in patients with hyperparathyroidism after renal transplantation. Am J Transplant 2008; 8: 803-810. (Pubitemid 351347748)
38. Borchhardt KA, Heinzl H, Mayerwoger E, Horl WH, Haas M, Sunder-Plassmann G: Cinacalcet increases calcium excretion in hypercalcemic hyperparathyroidism after kidney transplantation. Transplantation 2008; 86: 919-924.