Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays. Are autoantibodies really autoantibodies?

Experimental and Molecular Pathology

Volumn 92, Issue 3, 2012, Pages 304-311

  Kroening, Kaitlin ^a   Johnston, Stephen Albert ^a   Legutki, Joseph Barten ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Antigen discovery; Autoantibody; Frameshift peptide; Protein microarray; Random peptide

Indexed keywords

LYSYLTHREONYLPHENYLALANYLLYSYLSERYLGLUTAMYLPROLYLALANYLTYROSYLASPARAGINYLISOLEUCYLGLUTAMYLSERYLASPARAGINYLSERYLSERYLTHREONYLGLYCYLSERYLCYSTEINE; METHIONYLVALYLASPARTYLGLUTAMYLALANYLPROLYLGLUTAMYLGLUTAMINYLALANYLTYROSYLLEUCYLARGINYLLYSYLPHENYLALANYLISOLEUCYLGLUTAMINYLISOLEUCYLGLYCYLSERYLGLUTAMINE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; FEMALE; FRAMESHIFT MUTATION; IMMUNE RESPONSE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PROTEIN MICROARRAY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS; AUTOANTIBODIES; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOCYANIN; HUMANS; IMMUNIZATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ARRAY ANALYSIS;

EID: 84859149826     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.03.002     Document Type: Article

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