LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Lu, Hao K ^a   Mitchell, Ainslie ^a   Endoh, Yasumi ^a   Hampartzoumian, Taline ^a   Huynh, Owen ^a   Borges, Luis ^c   Geczy, Carolyn ^a   Bryant, Katherine ^a,b   Tedla, Nicodemus ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR A2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; LEUKOCYTE; LYMPHOCYTE DIFFERENTIATION; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; UPREGULATION;

ESCHERICHIA COLI;

EID: 84859149168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033478     Document Type: Article

References (45)

1. Colonna M, Nakajima H, Navarro F, Lopez-Botet M, (1999) A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J Leuk Biol 66: 375-381.
2. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D, (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J Immunol 159: 5192-5196.
3. Nakajima H, Samaridis J, Angman L, Colonna M, (1999) Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain. J Immunol 162: 5-8.
4. Tedla N, Bandeira-Melo C, Tassinari P, Sloane DE, Samplaski M, et al. (2003) Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc Natl Acad Sci USA 100: 1174-1179.
5. Sloane DE, Tedla N, Awoniyi M, Macglashan DW Jr, Borges L, et al. (2004) Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 104: 2832-2839.
6. Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, et al. (2007) LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol 179: 8128-8136.
7. Huynh OA, Hampartzoumian T, Arm JP, Hunt J, Borges L, et al. (2007) Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 46: 742-751.
8. Tedla N, Gibson K, McNeil HP, Cosman D, Borges L, et al. (2002) The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Am J Pathol 160: 425-431.
9. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, et al. (2003) Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science 301: 1527-1530.
10. Zarember KA, Godowski PJ, (2002) Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168: 554-561.
11. Fitzgerald KA, Rowe DC, Golenbock DT, (2004) Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect 6: 1361-1367.
12. Daeron M, (1997) Fc receptor biology. Annu Rev Immunol 15: 203-234.
13. Graziano RF, Fanger MW, (1987) Fc gamma RI and Fc gamma RII on monocytes and granulocytes are cytotoxic trigger molecules for tumor cells. J Immunol 139: 3536-3541.
14. Debets JM, Van der Linden CJ, Dieteren IE, Leeuwenberg JF, Buurman WA, (1988) Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. J Immunol 141: 1197-1201.
15. Peltz G, Frederick K, Anderson CL, Peterlin BM, (1988) Characterization of the human monocyte high affinity Fc receptor (hu FcRI). Mol Immunol 25: 243-250.
16. Debets JM, Van de Winkel JC, Ceuppens JL, Dieteren IE, Buurman WA, (1990) Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidase. J Immunol 144: 1304-1310.
17. Cosman D, Fanger N, Borges L, Kubin M, Chin W, et al. (1997) A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7: 273-282.
18. Fanger N, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L, (1998) The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol 28: 3423-3434.
19. Mitchell A, Endoh Y, Hsu K, Gaus K, Geczy C, et al. (2008) LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma. Eur J Immunol 38: 3459-3473.
20. Tedla N, Lee CW, Borges L, Geczy CL, Arm JP, (2008) Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells. J Leuk Biol 83: 334-343.
21. Lu HK, Rentero C, Raftery MJ, Borges L, Bryant K, Tedla N, (2009) Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases. J Biol Chem 284: 34839-34848.
22. Ibeagha-Awemu EM, Lee JW, Ibeagha AE, Bannerman MM, Paape MJ, et al. (2008) Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells. Vet Res 39: 11.
23. Endoh Y, Chung YM, Clark IA, Geczy CL, Hsu K, (2009) IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA. J Immunol 182: 2258-2268.
24. Stevens P, Young LS, Adamu S, (1983) Opsonization of various capsular (K) E-coli by alternative complement pathway. Immunol 50: 497-502.
25. Brown D, Trowsdale J, Allen R, (2004) The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens 64: 215-225.
26. Borges L, Cosman D, (2000) LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells. Cytokine Growth Factor Rev 11: 209-217.
27. Huang J, Burke PS, Cung TD, Pereyra F, Toth I, et al. (2010) Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol 84: 9463-9471.
28. Sieling PA, Wang XH, Gately MK, Oliveros JL, McHugh T, et al. (1994) IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol 153: 3639-3647.
29. Conti L, Cardone M, Varano B, Puddu P, Belardelli F, Gessani S, (2008) Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes. Eur J Immunol 38: 750-62.
30. Hornell TM, Beresford GW, Bushey A, Boss JM, Mellins ED, (2003) Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor. J Immunol 171: 2374-83.
31. Pojda Z, Struzyna J, (1994) Treatment of non-healing ulcers with rhGM-CSF and skin grafts. Lancet 343: 1100.
32. Deshmane SL, Kremlev S, Amini S, Sawaya BE, (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 29: 313-326.
33. Billadeau DD, Leibson PJ, (2002) ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest 109: 161-168.
34. Veillette A, Latour S, Davidson D, (2002) Negative regulation of immunoreceptor signaling. Ann Rev Immunol 20: 669-707.
35. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, et al. (2009) Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 206: 1603-1614.
36. Cao W, D. Rosen B, Ito T, Bover L, Bao M, et al. (2006) Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med 203: 1399-1405.
37. Pasquier B, Launay P, Kanamaru Y, Moura IC, Pfirsch S, et al. (2005) Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22: 31-42.
38. Hamerman JA, Tchao NK, Lowell CA, Lanier LL, (2005) Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 6: 579-586.
39. Wang L, Gordon RA, Huynh L, Su X, Park Min KH, et al. (2010) Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity 32: 518-530.
40. Blank U, Launay P, Benhamou M, Monteiro RC, (2009) Inhibitory ITAMs as novel regulators of immunity. Immunol Rev 232: 59-71.
41. Takeda K, Akira S, (2004) TLR signaling pathways. Semin Immunol 16: 3-9.
42. Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, et al. (1999) Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 163: 6403-12.
43. Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, et al. (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113: 2324-35.
44. Netea MG, Simon A, van de Veerdonk F, Kullberg BJ, Van der Meer JW, et al. (2010) IL-1beta processing in host defense: beyond the inflammasomes. PLoS Pathog 6: e1000661.
45. An H, Hou J, Zhou J, Zhao W, Xu H, et al. (2008) Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol 9: 542-50.