메뉴 건너뛰기




Volumn 60, Issue 12, 2012, Pages 3086-3091

Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase

Author keywords

endothelial nitric oxide synthase; ginsenoside; nitric oxide; spontaneously hypertensive rats

Indexed keywords

BIOCHEMICAL MECHANISMS; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); GINSENG EXTRACTS; GINSENOSIDES; IN-VITRO; NO RELEASE; PANAX GINSENG; SPONTANEOUSLY HYPERTENSIVE RATS; SYSTEMIC BLOOD PRESSURE; VASCULAR ENDOTHELIAL CELLS; VESSEL WALLS;

EID: 84859129536     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf204447y     Document Type: Article
Times cited : (40)

References (33)
  • 1
    • 38849198659 scopus 로고    scopus 로고
    • Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice
    • Liu, V. W.; Huang, P. L. Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice Cardiovasc. Res. 2008, 77, 19-29
    • (2008) Cardiovasc. Res. , vol.77 , pp. 19-29
    • Liu, V.W.1    Huang, P.L.2
  • 2
    • 0028860287 scopus 로고
    • Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine
    • Matsuda, T.; Bates, J. N.; Lewis, S. J.; Abboud, F. M.; Chapleau, M. W. Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine Circ. Res. 1995, 76, 426-433
    • (1995) Circ. Res. , vol.76 , pp. 426-433
    • Matsuda, T.1    Bates, J.N.2    Lewis, S.J.3    Abboud, F.M.4    Chapleau, M.W.5
  • 3
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro, L. J.; Buga, G. M.; Wood, K. S.; Byrns, R. E.; Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide Proc. Natl. Acad. Sci. U.S.A. 1987, 84, 9265-9269
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 4
    • 0024390169 scopus 로고
    • Endothelium-derived relaxing and contracting factors
    • Furchgott, R. F.; Vanhoutte, P. M. Endothelium-derived relaxing and contracting factors FASEB J. 1989, 3, 2007-2018
    • (1989) FASEB J. , vol.3 , pp. 2007-2018
    • Furchgott, R.F.1    Vanhoutte, P.M.2
  • 5
    • 0026609864 scopus 로고
    • NG-methyl- l -arginine, an inhibitor of l -arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?
    • Sakuma, I.; Togashi, H.; Yoshioka, M.; Saito, H.; Yanagida, M.; Tamura, M.; Kobayashi, T.; Yasuda, H.; Gross, S. S.; Levi, R. NG-methyl- l -arginine, an inhibitor of l -arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone? Circ. Res. 1992, 70, 607-611
    • (1992) Circ. Res. , vol.70 , pp. 607-611
    • Sakuma, I.1    Togashi, H.2    Yoshioka, M.3    Saito, H.4    Yanagida, M.5    Tamura, M.6    Kobayashi, T.7    Yasuda, H.8    Gross, S.S.9    Levi, R.10
  • 6
    • 77958464682 scopus 로고    scopus 로고
    • Advances in pharmacologic modulation of nitric oxide in hypertension
    • Mizuno, Y.; Jacob, R. F.; Mason, R. P. Advances in pharmacologic modulation of nitric oxide in hypertension Curr. Cardiol. Rep. 2010, 12, 472-480
    • (2010) Curr. Cardiol. Rep. , vol.12 , pp. 472-480
    • Mizuno, Y.1    Jacob, R.F.2    Mason, R.P.3
  • 7
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginsen g pharmacology: A nitric oxide link?
    • Gillis, C. N. Panax ginsen g pharmacology: a nitric oxide link? Biochem. Pharmacol. 1997, 54, 1-8
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 8
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • Leung, K. W.; Wong, A. S. Pharmacology of ginsenosides: a literature review Chin. Med. 2010, 5, 20
    • (2010) Chin. Med. , vol.5 , pp. 20
    • Leung, K.W.1    Wong, A.S.2
  • 9
    • 33846013596 scopus 로고    scopus 로고
    • Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
    • Leung, K. W.; Pon, Y. L.; Wong, R. N.; Wong, A. S. Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells J. Biol. Chem. 2006, 281, 36280-36288
    • (2006) J. Biol. Chem. , vol.281 , pp. 36280-36288
    • Leung, K.W.1    Pon, Y.L.2    Wong, R.N.3    Wong, A.S.4
  • 10
    • 0030838299 scopus 로고    scopus 로고
    • Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor
    • Lee, Y. J.; Chung, E.; Lee, K. Y.; Lee, Y. H.; Huh, B.; Lee, S. K. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor Mol. Cell. Endocrinol. 1997, 133, 135-140
    • (1997) Mol. Cell. Endocrinol. , vol.133 , pp. 135-140
    • Lee, Y.J.1    Chung, E.2    Lee, K.Y.3    Lee, Y.H.4    Huh, B.5    Lee, S.K.6
  • 11
    • 33646556664 scopus 로고    scopus 로고
    • Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells
    • Leung, K. W.; Cheng, Y. K.; Mak, N. K.; Chan, K. K.; Fan, T. P.; Wong, R. N. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells FEBS Lett. 2006, 580, 3211-3216
    • (2006) FEBS Lett. , vol.580 , pp. 3211-3216
    • Leung, K.W.1    Cheng, Y.K.2    Mak, N.K.3    Chan, K.K.4    Fan, T.P.5    Wong, R.N.6
  • 12
    • 65349185491 scopus 로고    scopus 로고
    • Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells
    • Leung, K. W.; Leung, F. P.; Mak, N. K.; Tombran-Tink, J.; Huang, Y.; Wong, R. N. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells Br. J. Pharmacol. 2009, 156, 626-637
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 626-637
    • Leung, K.W.1    Leung, F.P.2    Mak, N.K.3    Tombran-Tink, J.4    Huang, Y.5    Wong, R.N.6
  • 13
    • 0028914837 scopus 로고
    • Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta
    • Kang, S. Y.; Schini-Kerth, V. B.; Kim, N. D. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta Life Sci 1995, 56, 1577-1586
    • (1995) Life Sci , vol.56 , pp. 1577-1586
    • Kang, S.Y.1    Schini-Kerth, V.B.2    Kim, N.D.3
  • 14
    • 34248590312 scopus 로고    scopus 로고
    • Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor
    • Leung, K. W.; Leung, F. P.; Huang, Y.; Mak, N. K.; Wong, R. N. Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor FEBS Lett. 2007, 581, 2423-2428
    • (2007) FEBS Lett. , vol.581 , pp. 2423-2428
    • Leung, K.W.1    Leung, F.P.2    Huang, Y.3    Mak, N.K.4    Wong, R.N.5
  • 15
    • 34948887630 scopus 로고    scopus 로고
    • Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor
    • Leung, K. W.; Cheung, L. W.; Pon, Y. L.; Wong, R. N.; Mak, N. K.; Fan, T. P.; Au, S. C.; Tombran-Tink, J.; Wong, A. S. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor Br. J. Pharmacol. 2007, 152, 207-215
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 207-215
    • Leung, K.W.1    Cheung, L.W.2    Pon, Y.L.3    Wong, R.N.4    Mak, N.K.5    Fan, T.P.6    Au, S.C.7    Tombran-Tink, J.8    Wong, A.S.9
  • 16
    • 33646001775 scopus 로고    scopus 로고
    • Oral absorption of ginsenoside Rb1 using in vitro and in vivo models
    • Han, M.; Sha, X.; Wu, Y.; Fang, X. Oral absorption of ginsenoside Rb1 using in vitro and in vivo models Planta Med. 2006, 72, 398-404
    • (2006) Planta Med. , vol.72 , pp. 398-404
    • Han, M.1    Sha, X.2    Wu, Y.3    Fang, X.4
  • 17
    • 78751504470 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats
    • Feng, L.; Wang, L.; Hu, C.; Jiang, X. Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats Arch. Pharm. Res. 2010, 33, 1975-1984
    • (2010) Arch. Pharm. Res. , vol.33 , pp. 1975-1984
    • Feng, L.1    Wang, L.2    Hu, C.3    Jiang, X.4
  • 18
    • 33645214063 scopus 로고    scopus 로고
    • Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models
    • Han, M.; Fang, X. L. Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models Acta Pharmacol. Sin. 2006, 27, 499-505
    • (2006) Acta Pharmacol. Sin. , vol.27 , pp. 499-505
    • Han, M.1    Fang, X.L.2
  • 19
    • 0015598460 scopus 로고
    • Formalin fixation for electron microscopy: A re-evaluation
    • Carson, F. L.; Martin, J. H.; Lynn, J. A. Formalin fixation for electron microscopy: a re-evaluation Am. J. Clin. Pathol. 1973, 59, 365-373
    • (1973) Am. J. Clin. Pathol. , vol.59 , pp. 365-373
    • Carson, F.L.1    Martin, J.H.2    Lynn, J.A.3
  • 20
    • 3242689060 scopus 로고    scopus 로고
    • Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamil
    • Pereira, L. M.; Bezerra, D. G.; Mandarim-de-Lacerda, C. A. Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamil Pathol. Res. Pract. 2004, 200, 211-217
    • (2004) Pathol. Res. Pract. , vol.200 , pp. 211-217
    • Pereira, L.M.1    Bezerra, D.G.2    Mandarim-De-Lacerda, C.A.3
  • 21
    • 0029057806 scopus 로고
    • Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes
    • Balligand, J. L.; Kobzik, L.; Han, X.; Kaye, D. M.; Belhassen, L.; O'Hara, D. S.; Kelly, R. A.; Smith, T. W.; Michel, T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes J. Biol. Chem. 1995, 270, 14582-14586
    • (1995) J. Biol. Chem. , vol.270 , pp. 14582-14586
    • Balligand, J.L.1    Kobzik, L.2    Han, X.3    Kaye, D.M.4    Belhassen, L.5    O'Hara, D.S.6    Kelly, R.A.7    Smith, T.W.8    Michel, T.9
  • 22
    • 79952279289 scopus 로고    scopus 로고
    • Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats
    • Miguel, M.; Gómez-Ruiz, J.; Recio, I.; Aleixandre, A. Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats Mol. Nutr. Food Res. 2010, 54, 1422-1427
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1422-1427
    • Miguel, M.1    Gómez-Ruiz, J.2    Recio, I.3    Aleixandre, A.4
  • 23
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler, S.; Fleming, I.; Fisslthaler, B.; Hermann, C.; Busse, R.; Zeiher, A. M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 1999, 399, 601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 25
    • 0036854547 scopus 로고    scopus 로고
    • Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension
    • Kitayama, J.; Kitazono, T.; Ooboshi, H.; Ago, T.; Ohgami, T.; Fujishima, M.; Ibayashi, S. Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension J. Hypertens. 2002, 20, 2205-2211
    • (2002) J. Hypertens. , vol.20 , pp. 2205-2211
    • Kitayama, J.1    Kitazono, T.2    Ooboshi, H.3    Ago, T.4    Ohgami, T.5    Fujishima, M.6    Ibayashi, S.7
  • 27
    • 0022574146 scopus 로고
    • Induction by IL 1 and interferon-γ: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)
    • Dustin, M. L.; Rothlein, R.; Bhan, A. K.; Dinarello, C. A.; Springer, T. A. Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1) J. Immunol. 1986, 186, 245-254
    • (1986) J. Immunol. , vol.186 , pp. 245-254
    • Dustin, M.L.1    Rothlein, R.2    Bhan, A.K.3    Dinarello, C.A.4    Springer, T.A.5
  • 31
    • 68149137621 scopus 로고    scopus 로고
    • ENOS, metabolic syndrome and cardiovascular disease
    • Huang, P. L. eNOS, metabolic syndrome and cardiovascular disease Trends Endocrinol. Metab. 2009, 20, 295-302
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 295-302
    • Huang, P.L.1
  • 32
    • 3042730959 scopus 로고    scopus 로고
    • ENOS at a glance
    • Sessa, W. C. eNOS at a glance J. Cell Sci. 2004, 117, 2427-2429
    • (2004) J. Cell Sci. , vol.117 , pp. 2427-2429
    • Sessa, W.C.1
  • 33
    • 1542782162 scopus 로고    scopus 로고
    • Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP
    • Jiang, J.; Cyr, D.; Babbitt, R. W.; Sessa, W. C.; Patterson, C. Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP J. Biol. Chem. 2003, 278, 49332-49341
    • (2003) J. Biol. Chem. , vol.278 , pp. 49332-49341
    • Jiang, J.1    Cyr, D.2    Babbitt, R.W.3    Sessa, W.C.4    Patterson, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.