Hemoglobin levels and transfusions in neurocritically ill patients: A systematic review of comparative studies

Critical Care

Volumn 16, Issue 2, 2012, Pages

  Desjardins, Philippe ^a   Turgeon, Alexis F ^a,b   Tremblay, Marie Hélène ^a   Lauzier, François ^a,b,c   Zarychanski, Ryan ^d   Boutin, Amélie ^b   Moore, Lynne ^b,c   McIntyre, Lauralyn A ^e,f   English, Shane W ^e   Rigamonti, Andrea ^g   Lacroix, Jacques ^h   Fergusson, Dean A ^f  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d UNIVERSITY OF MANITOBA   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

^f OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ARTICLE; ARTIFICIAL VENTILATION; BLOOD TRANSFUSION; COCHRANE LIBRARY; CONFIDENCE INTERVAL; CRITICALLY ILL PATIENT; EMBASE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFORMATION RETRIEVAL; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MEDLINE; MORTALITY; MULTIPLE ORGAN FAILURE; NERVE FUNCTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK; SUBARACHNOID HEMORRHAGE; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; WEB BROWSER; BLOOD; BRAIN DISEASE; CRITICAL ILLNESS; METABOLISM; STATISTICS AND NUMERICAL DATA;

BLOOD TRANSFUSION; BRAIN DISEASES; CRITICAL ILLNESS; HEMOGLOBINS; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MULTIPLE ORGAN FAILURE; RESPIRATION, ARTIFICIAL;

EID: 84859118059     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11293     Document Type: Article

References (54)

1. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, MacIntyre NR, Shabot MM, Duh MS, Shapiro MJ. The CRIT Study: anemia and blood transfusion in the critically ill: current clinical practice in the United States. Crit Care Med 2004, 32:39-52. 10.1097/01.CCM.0000104112.34142.79, 14707558.
2. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, Meier-Hellmann A, Nollet G, Peres-Bota D. Anemia and blood transfusion in critically ill patients. JAMA 2002, 288:1499-1507. 10.1001/jama.288.12.1499, 12243637.
3. Rawn J. The silent risks of blood transfusion. Curr Opin Anaesthesiol 2008, 21:664-668. 10.1097/ACO.0b013e32830f1fd1, 18784496.
4. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care: Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340:409-417. 10.1056/NEJM199902113400601, 9971864.
5. Vincent JL, Piagnerelli M. Transfusion in the intensive care unit. Crit Care Med 2006, 34:S96-101. 10.1097/01.CCM.0000214314.57109.CD, 16617264.
6. Lacroix J, Hebert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007, 356:1609-1619. 10.1056/NEJMoa066240, 17442904.
7. Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36:2667-2674. 10.1097/CCM.0b013e3181844677, 18679112.
8. Carless PA, Henry DA, Carson JL, Hebert PP, McClelland B, Ker K. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2010, CD002042.
9. Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the transfusion of red blood cells. Blood Transfus 2009, 7:49-64. 2652237, 19290081.
10. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327. Erratum in: Crit Care Med 2008, 36:1394-1396, 10.1097/01.CCM.0000298158.12101.41, 18158437.
11. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006, 105:198-208. 10.1097/00000542-200607000-00030, 16810012, American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies.
12. Nichol AD. Restrictive red blood cell transfusion strategies in critical care: does one size really fit all?. Crit Care Resusc 2008, 10:323-327.
13. Spiotta AM, Stiefel MF, Gracias VH, Garuffe AM, Kofke WA, Maloney-Wilensky E, Troxel AB, Levine JM, Le Roux PD. Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury. J Neurosurg 2010, 113:571-580. 10.3171/2010.1.JNS09506, 20415526.
14. Narotam PK, Morrison JF, Nathoo N. Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy. J Neurosurg 2009, 111:672-682. 10.3171/2009.4.JNS081150, 19463048.
15. Pendem S, Rana S, Manno EM, Gajic O. A review of red cell transfusion in the neurological intensive care unit. Neurocrit Care 2006, 4:63-67. 10.1385/NCC:4:1:063, 16498197.
16. Leal-Noval SR, Munoz-Gomez M, Murillo-Cabezas F. Optimal hemoglobin concentration in patients with subarachnoid hemorrhage, acute ischemic stroke and traumatic brain injury. Curr Opin Crit Care 2008, 14:156-162. 10.1097/MCC.0b013e3282f57577, 18388677.
17. Utter GH, Shahlaie K, Zwienenberg-Lee M, Muizelaar JP. Anemia in the setting of traumatic brain injury: the arguments for and against liberal transfusion. J Neurotrauma 2011, 28:155-165. 10.1089/neu.2010.1451, 20954887.
18. Kramer AH, Zygun DA. Anemia and red blood cell transfusion in neurocritical care. Crit Care 2009, 13:R89. 10.1186/cc7916, 2717460, 19519893.
19. Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA. Clinical practice guideline: red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009, 37:3124-3157. Erratum in Crit Care Med 2010, 38:1621, 10.1097/CCM.0b013e3181b39f1b, 19773646.
20. Diringer MN, Bleck TP, Claude Hemphill J, Menon D, Shutter L, Vespa P, Bruder N, Connolly ES, Citerio G, Gress D, Hanggi D, Hoh BL, Lanzino G, Le Roux P, Rabinstein A, Schmutzhard E, Stocchetti N, Suarez JI, Treggiari M, Tseng MY, Vergouwen MD, Wolf S, Zipfel G. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference. Neurocrit Care 2011, 15:211-240. 10.1007/s12028-011-9605-9, 21773873.
21. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6:e1000097. 10.1371/journal.pmed.1000097, 2707599, 19621072.
22. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995, 23:1638-1652. 10.1097/00003246-199510000-00007, 7587228.
23. Cochrane Handbook for Systematic Reviews of Interventions Higgins J, Green S, Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available from www.cochrane-handbook.org/.
24. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998, 52:377-384. 10.1136/jech.52.6.377, 1756728, 9764259.
25. Quinto L, Aponte JJ, Menendez C, Sacarlal J, Aide P, Espasa M, Mandomando I, Guinovart C, Macete E, Hirt R, Urassa H, Navia MM, Thompson R, Alonso PL. Relationship between haemoglobin and haematocrit in the definition of anaemia. Trop Med Int Health 2006, 11:1295-1302. 10.1111/j.1365-3156.2006.01679.x, 16903892.
26. McIntyre LA, Fergusson DA, Hutchison JS, Pagliarello G, Marshall JC, Yetisir E, Hare GM, Hebert PC. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 2006, 5:4-9. 10.1385/NCC:5:1:4, 16960287.
27. Fluckiger C, Bechir M, Brenni M, Ludwig S, Sommerfeld J, Cottini SR, Keel M, Stocker R, Stover JF. Increasing hematocrit above 28% during early resuscitative phase is not associated with decreased mortality following severe traumatic brain injury. Acta Neurochir (Wien) 2010, 152:627-636.
28. George ME, Skarda DE, Watts CR, Pham HD, Beilman GJ. Aggressive red blood cell transfusion: no association with improved outcomes for victims of isolated traumatic brain injury. Neurocrit Care 2008, 8:337-343. 10.1007/s12028-008-9066-y, 18273711.
29. Warner MA, O'Keeffe T, Bhavsar P, Shringer R, Moore C, Harper C, Madden CJ, Sarode R, Gentilello LM, Diaz-Arrastia R. Transfusions and long-term functional outcomes in traumatic brain injury. J Neurosurg 2010, 113:539-546. 10.3171/2009.12.JNS091337, 20113158.
30. Naidech AM, Shaibani A, Garg RK, Duran IM, Liebling SM, Bassin SL, Bendok BR, Bernstein RA, Batjer HH, Alberts MJ. Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. Neurocrit Care 2010, 13:313-320. 10.1007/s12028-010-9424-4, 20717750.
31. Zygun DA, Nortje J, Hutchinson PJ, Timofeev I, Menon DK, Gupta AK. The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury. Crit Care Med 2009, 37:1074-1078. 10.1097/CCM.0b013e318194ad22, 19237920.
32. Fisher MR, Topley E. The illness of trauma. Br J Clin Pract 1956, 10:770-776.
33. Fortune JB, Feustel PJ, Saifi J, Stratton HH, Newell JC, Shah DM. Influence of hematocrit on cardiopulmonary function after acute hemorrhage. J Trauma 1987, 27:243-249. 10.1097/00005373-198703000-00003, 3560265.
34. Bhavsar P, Shringer R, O'Keefe T, Moore C, Harper C, Madden C, Sarode R, Gentilello L, Diaz-Arrastia R. Observational cohort study of the impact of anemia and transfusion on outcome after traumatic brain injury. Neurology 2009, 72:A76.
35. Wartenberg K, Schmidt J, Fernandez A, Claassen J, Ostapkovich N, Palestrant D, Augusto P, Mayer S, Badjatia N, Frontera J. Impact of red blood cell transfusion on outcome after subarachnoid hemorrhage. Crit Care Med 2006, 34:A124(445).
36. Robertson C. Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury. Study start date: April 2006 Estimated study completion date 2013, ClinicalTrials.gov http://clinicaltrials.gov/ct2/show/NCT00313716/.
37. Burke AM, Quest DO, Chien S, Cerri CN. The effects of mannitol on blood viscosity. J Neurosurg 1981, 55:550-553. 10.3171/jns.1981.55.4.0550, 6792325.
38. Mertes PM, Baumann A, Audibert G. Transfusion in neurosurgery. Transfus Clin Biol 2008, 15:205-211. 10.1016/j.tracli.2008.09.011, 18930420.
39. Salim A, Hadjizacharia P, DuBose J, Brown C, Inaba K, Chan L, Margulies DRN. Role of anemia in traumatic brain injury. J Am Coll Surg 2008, 207:398-406. 10.1016/j.jamcollsurg.2008.03.013, 18722946.
40. Van Beek JG, Mushkudiani NA, Steyerberg EW, Butcher I, McHugh GS, Lu J, Marmarou A, Murray GD, Maas AI. Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007, 24:315-328. 10.1089/neu.2006.0034, 17375996.
41. Carlson AP, Schermer CR, Lu SW. Retrospective evaluation of anemia and transfusion in traumatic brain injury. J Trauma 2006, 61:567-571. 10.1097/01.ta.0000231768.44727.a2, 16966988.
42. Schirmer-Mikalsen K, Vik A, Gisvold SE, Skandsen T, Hynne H, Klepstad P. Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit. Acta Anaesthesiol Scand 2007, 51:1194-1201.
43. Naidech AM, Drescher J, Ault ML, Shaibani A, Batjer HH, Alberts MJ. Higher hemoglobin is associated with less cerebral infarction, poor outcome, and death after subarachnoid hemorrhage. Neurosurgery 2006, 59:775-779. discussion 779-780, 10.1227/01.NEU.0000232662.86771.A9, 17038943.
44. Wartenberg KE, Schmidt JM, Claassen J, Temes RE, Frontera JA, Ostapkovich N, Parra A, Connolly ES, Mayer SA. Impact of medical complications on outcome after subarachnoid hemorrhage. Crit Care Med 2006, 34:617-623. quiz 624.
45. Kramer AH, Zygun DA, Bleck TP, Dumont AS, Kassell NF, Nathan BN. Relationship between hemoglobin concentrations and outcomes across subgroups of patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care 2009, 10:157-165. 10.1007/s12028-008-9171-y, 19116699.
46. Oddo M, Milby A, Chen I, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel M, Kofke WA, Levine JM, Le Roux PD. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage. Stroke 2009, 40:1275-1281. 10.1161/STROKEAHA.108.527911, 19265059.
47. Kurtz P, Schmidt JM, Claassen J, Carrera E, Fernandez L, Helbok R, Presciutti M, Stuart RM, Connolly ES, Badjatia N, Mayer SA, Lee KN. Anemia is associated with metabolic distress and brain tissue hypoxia after subarachnoid hemorrhage. Neurocrit Care 2010, 13:10-16. 10.1007/s12028-010-9357-y, 20383611.
48. Figaji AA, Zwane E, Kogels M, Fieggen AG, Argent AC, Le Roux PD, Peter JC. The effect of blood transfusion on brain oxygenation in children with severe traumatic brain injury. Pediatr Crit Care Med 2010, 11:325-331.
49. Smith MJ, Stiefel MF, Magge S, Frangos S, Bloom S, Gracias V, Le Roux PD. Packed red blood cell transfusion increases local cerebral oxygenation. Crit Care Med 2005, 33:1104-1108. 10.1097/01.CCM.0000162685.60609.49, 15891343.
50. Leal-Noval SR, Rincon-Ferrari MD, Marin-Niebla A, Cayuela A, Arellano-Orden V, Marin-Caballos A, Amaya-Villar R, Ferrandiz-Millon C, Murillo-Cabeza F. Transfusion of erythrocyte concentrates produces a variable increment on cerebral oxygenation in patients with severe traumatic brain injury: a preliminary study. Intensive Care Med 2006, 32:1733-1740. 10.1007/s00134-006-0376-2, 17019549.
51. Wartenberg KE, Mayer SA. Medical complications after subarachnoid hemorrhage: new strategies for prevention and management. Curr Opin Crit Care 2006, 12:78-84. 10.1097/01.ccx.0000216571.80944.65, 16543780.
52. Kramer AH, Gurka MJ, Nathan B, Dumont AS, Kassell NF, Bleck TP. Complications associated with anemia and blood transfusion in patients with aneurysmal subarachnoid hemorrhage. Crit Care Med 2008, 36:2070-2075. 10.1097/CCM.0b013e31817c1095, 18552682.
53. Levine J, Kofke A, Cen L, Chen Z, Faerber J, Elliott JP, Winn HR, Le Roux P. Red blood cell transfusion is associated with infection and extracerebral complications after subarachnoid hemorrhage. Neurosurgery 2010, 66:312-318. discussion 318, 10.1227/01.NEU.0000363747.47587.6C, 20042985.
54. Smith MJ, Le Roux PD, Elliott JP, Winn HR. Blood transfusion and increased risk for vasospasm and poor outcome after subarachnoid hemorrhage. J Neurosurg 2004, 101:1-7. 10.3171/jns.2004.101.1.0001, 16206964.