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Cunningham AS, Salvador R, Coles JP, et al. Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. Brain 2005; 128:1931-1942.
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Cunningham, A.S.1
Salvador, R.2
Coles, J.P.3
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54
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Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
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Hare GT, Mazer CD, Hutchison JS, et al. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiol 2007; 103:1021-1029.
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Hare, G.T.1
Mazer, C.D.2
Hutchison, J.S.3
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55
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Multimodal monitoring in traumatic brain injury: Current status and future directions
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Tisdall MM, Smith M. Multimodal monitoring in traumatic brain injury: current status and future directions. Br J Anaesth 2007; 99:61-67.
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Tisdall, M.M.1
Smith, M.2
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56
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Blood transfusion, independent of shock severity, is associated with worse outcome in trauma
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Malone DL, Dunne J, Tracy JK, et al. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003; 54:898-907.
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Malone, D.L.1
Dunne, J.2
Tracy, J.K.3
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57
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Retrospective evaluation of anemia and transfusion in traumatic brain injury
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Retrospective evaluation of 169 patients with severe TBI, in which transfusion and lowest measured hematocrit were both significantly associated with lower outcome scores on hospital discharge. Mid-range hematocrit values were not associated with worse clinical outcomes
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Carson AP, Schermer CR, Stephen WL. Retrospective evaluation of anemia and transfusion in traumatic brain injury. J Trauma 2006; 61:567-571. Retrospective evaluation of 169 patients with severe TBI, in which transfusion and lowest measured hematocrit were both significantly associated with lower outcome scores on hospital discharge. Mid-range hematocrit values were not associated with worse clinical outcomes.
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J Trauma
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Carson, A.P.1
Schermer, C.R.2
Stephen, W.L.3
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McIntyre LA, Fergusson DA, Hutchison JS, et al. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 2006; 5:4-9. Post-hoc analysis of TRICC trial [7] involving only 67 critically ill patients who sustained a closed head injury. Patients were randomized to a restrictive RBCT strategy (hemoglobin between 7.0 and 9.0 g/dl) or a liberal strategy (hemoglobin between 10.0 and 12.0 g/dl). Even though no significant differences were found, the authors recommended cautious interpretation because of the many limitations of secondary analysis associated with RCTs.
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McIntyre LA, Fergusson DA, Hutchison JS, et al. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 2006; 5:4-9. Post-hoc analysis of TRICC trial [7] involving only 67 critically ill patients who sustained a closed head injury. Patients were randomized to a restrictive RBCT strategy (hemoglobin between 7.0 and 9.0 g/dl) or a liberal strategy (hemoglobin between 10.0 and 12.0 g/dl). Even though no significant differences were found, the authors recommended cautious interpretation because of the many limitations of secondary analysis associated with RCTs.
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59
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27744595770
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Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants
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Bell EF, Strauss RG, Widness JA, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005; 115:1685-1691.
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Bell, E.F.1
Strauss, R.G.2
Widness, J.A.3
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60
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Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149:301-307. This prospective study RCT enrolled 451 infants weighing less than 1000 g, who were randomized to receive RBCT according to low (n = 223) or high (n = 228) hemoglobin thresholds. There were no statistically significant differences between groups regarding to incidence of brain injury, as assessed by head ultrasound (12.6 vs. 16.0%, P = 0.53, respectively).
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Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149:301-307. This prospective study RCT enrolled 451 infants weighing less than 1000 g, who were randomized to receive RBCT according to low (n = 223) or high (n = 228) hemoglobin thresholds. There were no statistically significant differences between groups regarding to incidence of brain injury, as assessed by head ultrasound (12.6 vs. 16.0%, P = 0.53, respectively).
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61
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Transfusion thresholds for preterm infants: How low should we go?
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High hemoglobin concentrations seems to confer protection against brain damage
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Bell EF. Transfusion thresholds for preterm infants: how low should we go? J Pediatr 2006; 149:287-289. High hemoglobin concentrations seems to confer protection against brain damage.
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J Pediatr
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Bell, E.F.1
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Lacroix J, Hebert PC, Hutchison JS, et al. Transfusion strategies for patients in pediatric intensive care units. New Engl J Med 2007; 356:1609-1619. Randomized controlled trial enrolling 637 critically ill children (>3 years old and >14 kg of weight) allocated into two transfusion strategies (restrictive vs. liberal). No significant differences were found in outcomes, including neurological dysfunction (7% vs. 6%).
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Lacroix J, Hebert PC, Hutchison JS, et al. Transfusion strategies for patients in pediatric intensive care units. New Engl J Med 2007; 356:1609-1619. Randomized controlled trial enrolling 637 critically ill children (>3 years old and >14 kg of weight) allocated into two transfusion strategies (restrictive vs. liberal). No significant differences were found in outcomes, including neurological dysfunction (7% vs. 6%).
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63
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33646759539
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Physiologic transfusion triggers
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Editorial showing that transfusion triggers based on physiological cerebral parameters are probably better than arbitrary hemoglobin-based transfusion triggers
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Spahn DR, Madjdpour C. Physiologic transfusion triggers. Do we have to use (our) brain? Anesthesiology 2006; 104:905-1905. Editorial showing that transfusion triggers based on physiological cerebral parameters are probably better than arbitrary hemoglobin-based transfusion triggers.
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(2006)
Do we have to use (our) brain? Anesthesiology
, vol.104
, pp. 905-1905
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Spahn, D.R.1
Madjdpour, C.2
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64
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Cerebral and peripheral oxygen saturation during red cell transfusion
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Torella F, Haynes SL, McCollum CN. Cerebral and peripheral oxygen saturation during red cell transfusion. J Surg Res 2003; 110:217-221.
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J Surg Res
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Torella, F.1
Haynes, S.L.2
McCollum, C.N.3
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65
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Regional tissue oxygenation during hemorrhage: Can near infrared spectroscopy be used to monitor blood loss?
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Torella F, Cowley RD, Thorniley MS, McCollum CN. Regional tissue oxygenation during hemorrhage: can near infrared spectroscopy be used to monitor blood loss? Shock 2002; 18:440-444.
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Torella, F.1
Cowley, R.D.2
Thorniley, M.S.3
McCollum, C.N.4
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66
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Cerebral hypoxia in severely brain injured patients is associated with admission Glasgow Coma Scale, computed tomographic severity, cerebral perfusion pressure, and survival
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Dunham CM, Ransom KJ, Flowers LL, et al. Cerebral hypoxia in severely brain injured patients is associated with admission Glasgow Coma Scale, computed tomographic severity, cerebral perfusion pressure, and survival. J Trauma 2004; 56:482-491.
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J Trauma
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Dunham, C.M.1
Ransom, K.J.2
Flowers, L.L.3
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67
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Spanish consensus statement on alternatives to allogeneic transfusions: The 'Seville document'
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Leal-Noval SR, Múñoz M, Páramo JA, García Erce. Spanish consensus statement on alternatives to allogeneic transfusions: the 'Seville document'. TATM 2006; 8:178-202.
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TATM
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Leal-Noval, S.R.1
Múñoz, M.2
Páramo, J.A.3
Erce, G.4
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