High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes

Journal of Biomedical Materials Research - Part A

Volumn 100 A, Issue 5, 2012, Pages 1239-1247

  Gugerell, Alfred ^a,b   Schossleitner, Klaudia ^a   Wolbank, Susanne ^b,c   Nürnberger, Sylvia ^b   Redl, Heinz ^b,c   Gulle, Heinz ^a   Goppelt, Andreas ^a   Bittner, Michaela ^a   Pasteiner, Waltraud ^a  

^a BAXTER INNOVATIONS GMBH   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^c Austrian Cluster for Tissue Regeneration ^*  (Austria)

Author keywords

apoptosis; cell viability; fibrin sealant; keratinocytes; thrombin

Indexed keywords

APOPTOTIC MECHANISMS; CASPASE-3; CELL MORPHOLOGY; CELL VIABILITY; FIBRIN CLOTS; FIBRIN SEALANTS; HIGH CONCENTRATION; HUMAN KERATINOCYTES; KERATINOCYTES; NONCOVALENT BONDING; THREE-DIMENSIONAL STRUCTURE; THROMBIN;

ADHESION; SEALANTS;

CELL DEATH;

CASPASE 3; CASPASE 7; DEATH RECEPTOR 5; FIBRIN; FIBRIN GLUE; HIRUDIN; LACTATE DEHYDROGENASE; THROMBIN;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL PROLIFERATION; CELL SPREADING; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INDUCTION; EVALUATION; FIBRIN CLOT; HUMAN; HUMAN CELL; KERATINOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION;

APOPTOSIS; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL ADHESION; CELL COUNT; CELL SHAPE; FIBRIN TISSUE ADHESIVE; HIRUDINS; HUMANS; KERATINOCYTES; MICROSCOPY, ELECTRON, SCANNING; PROTEIN BINDING; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; THROMBIN;

EID: 84859104804     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34007     Document Type: Article

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