Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H 2O 2 via mechanisms involving AP-1 activation

Free Radical Research

Volumn 46, Issue 5, 2012, Pages 690-699

  Mata, Manuel ^a,b,c   Pallardo, Federico ^b   Morcillo, Esteban Jess ^b,c   Cortijo, Julio ^a,b,c  

^a HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

AP 1; Apoptosis; CAMP; Microarrays; Oxidative stress

Indexed keywords

BROXURIDINE; CXCL2 CHEMOKINE; FAS ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; HYDROGEN PEROXIDE; INTERLEUKIN 8; LIPOCORTIN 5; LUCIFERASE; PICLAMILAST; PROTEIN C JUN; SERINE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB;

ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; MICROARRAY ANALYSIS; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIOXIDANTS; APOPTOSIS; BENZAMIDES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHORYLATION; PNEUMOCYTES; PROTO-ONCOGENE PROTEINS C-JUN; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PYRIDINES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84859081628     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2012.669040     Document Type: Article

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