Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant

Biochemical and Biophysical Research Communications

Volumn 305, Issue 2, 2003, Pages 311-314

  Yeh, Chau Ting ^a,b   Lu, Su Chuan ^a   Chao, Chung Hao ^a   Chao, Mei Ling ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Aberrant transcripts; Crystal structure; Cyclin dependent kinase; Hepatoblastoma; Hepatocellular carcinoma; Interaction domain; Protein phosphatase; Truncated KAP mutants; Yeast three hybrid system; Yeast two hybrid system

Indexed keywords

CYCLIN DEPENDENT KINASE 2; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE DELETION; GENETIC PROCEDURES; HEPATOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; THREE HYBRID SYSTEM; TWO HYBRID SYSTEM; WILD TYPE; YEAST;

EID: 0038705973     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00757-5     Document Type: Article

References (14)

1. Solomon M.J. Activation of the various cyclin/Cdc2 protein kinases. Curr. Opin. Cell Biol. 5:1993;180-186.
2. Brown N.R., Novle M.E., Lawrie A.M., Morris M.C., Tunnah P., Divita G., Johnson L.N., Endicott J.A. Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity. J. Biol. Chem. 274:1999;8746-8756.
3. Atherton-Fessler S., Hannig G., Piwnica-Worms H. Reversible tyrosine phosphorylation and cell cycle control. Semin. Cell Biol. 4:1993;433-442.
4. Den Haese G.J., Walworth N., Carr A.M., Gould K.L. The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Mol. Biol. Cell. 6:1995;371-385.
5. Coleman T.R., Dunphy W.G. Cdc2 regulatory factors. Curr. Opin. Cell Biol. 6:1994;877-882.
6. Nigg E.A. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control. Curr. Opin. Cell Biol. 8:1996;312-317.
7. Kaldis P., Sutton A., Solomon M.J. The Cdk-activating kinase (CAK) from budding yeast. Cell. 86:1996;553-564.
8. Lew D.J., Kornbluth S. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr. Opin. Cell Biol. 8:1996;795-804.
9. Poon R.Y., Hunter T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science. 270:1995;90-93.
10. Hannon G.J., Casso D., Beach D. KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA. 91:1994;1731-1735.
11. Yeh C.-T., Lu S.-C., Chen T.-C., Peng C.-Y., Liaw Y.-F. Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. Cancer Res. 60:2000;4697-4700.
12. Song H., Hanlon N., Brown N.R., Noble M.E., Johnson L.N., Barford D. Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol. Cell. 7:2001;615-626.
13. Gyuris J., Golemis E., Chertkov H., Brent R. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell. 75:1993;791-803.
14. Lee S.W., Reimer C.L., Fang L., Iruela-Arispe M.L., Aaronson S.A. Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. Mol. Cell. Biol. 20:2000;1723-1732.