Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism

Chemico-Biological Interactions

Volumn 197, Issue 1, 2012, Pages 1-7

  Lim, Jun Hee ^a   Woo, Seon Min ^a   Min, Kyoung Jin ^a   Park, Eun Jung ^a   Jang, Ji Hoon ^a   Seo, Bo Ram ^a   Iqbal, Taha ^a   Lee, Tae Jin ^b   Kim, Sang Hyun ^c   Choi, Yung Hyun ^d   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

Apoptosis; Colon carcinoma cells; NAG 1; p53; Rottlerin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NONSTEROIDAL ANTIINFLAMMATORY DRUG ACTIVATED GENE 1 PROTEIN; PROTEIN KINASE C DELTA; ROTTLERIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CARCINOMA CELL; CELL STRAIN HT29; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONSTEROIDAL ANTIINFLAMMATORY DRUG ACTIVATED GENE 1; ONCOGENE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE;

ACETOPHENONES; APOPTOSIS; BENZOPYRANS; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENZYME INHIBITORS; GENE DELETION; GROWTH DIFFERENTIATION FACTOR 15; HT29 CELLS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-DELTA; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR CHOP; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84859079858     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.02.003     Document Type: Article

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