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Volumn 18, Issue 7-8, 2012, Pages 715-724

Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels

Author keywords

[No Author keywords available]

Indexed keywords

BIOMINERALIZATION; CALCIFICATION (BIOCHEMISTRY); CARTILAGE; CELL CULTURE; DYNAMICS; FLOW MEASUREMENT; FLOWCHARTING; HYDROGELS; MECHANICAL PROPERTIES; ORGANIC ACIDS; PATHOLOGY; STEM CELLS; TRANSPLANTATION (SURGICAL);

EID: 84859072783     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2011.0455     Document Type: Article
Times cited : (124)

References (58)
  • 1
    • 66249117350 scopus 로고    scopus 로고
    • Differential maturation and structure-function relationships in mesenchymal stem cell-and chondrocyte-seeded hydrogels
    • Erickson, I.E., Huang, A.H., Chung, C, Li, R.T., Burdick, J.A., and Mauck, R.L. Differential maturation and structure-function relationships in mesenchymal stem cell-and chondrocyte-seeded hydrogels. Tissue Eng Part A 15, 1041, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 1041
    • Erickson, I.E.1    Huang, A.H.2    Chung, C.3    Li, R.T.4    Burdick, J.A.5    Mauck, R.L.6
  • 3
    • 0041358606 scopus 로고    scopus 로고
    • In vitro chondrogenesis of bone marrowderived mesenchymal stem cells in a photopolymerizing hydrogel
    • Williams, C.G., Kim, T.K., Taboas, A., Malik, A., Manson, P., and Elisseeff, J. In vitro chondrogenesis of bone marrowderived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng 9, 679, 2003.
    • (2003) Tissue Eng , vol.9 , pp. 679
    • Williams, C.G.1    Kim, T.K.2    Taboas, A.3    Malik, A.4    Manson, P.5    Elisseeff, J.6
  • 4
    • 0025766618 scopus 로고
    • The effects of paralysis on skeletal development in the chick embryo. II. Effects on histogenesis of the tibia
    • Hosseini, A., and Hogg, D.A. The effects of paralysis on skeletal development in the chick embryo. II. Effects on histogenesis of the tibia. J Anat 177, 169, 1991.
    • (1991) J Anat , vol.177 , pp. 169
    • Hosseini, A.1    Hogg, D.A.2
  • 5
    • 2942587169 scopus 로고    scopus 로고
    • Mechanical modulation of cartilage structure and function during embryogenesis in the chick
    • Mikic, B., Isenstein, A.L., and Chhabra, A. Mechanical modulation of cartilage structure and function during embryogenesis in the chick. Ann Biomed Eng 32, 18, 2004.
    • (2004) Ann Biomed Eng , vol.32 , pp. 18
    • Mikic, B.1    Isenstein, A.L.2    Chhabra, A.3
  • 6
    • 0041328360 scopus 로고    scopus 로고
    • Tensile mechanical properties of bovine articular cartilage: Variations with growth and relationships to collagen network components
    • Williamson, A.K., Chen, A.C., Masuda, K., Thonar, E.J., and Sah, R.L. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res 21, 872, 2003.
    • (2003) J Orthop Res , vol.21 , pp. 872
    • Williamson, A.K.1    Chen, A.C.2    Masuda, K.3    Thonar, E.J.4    Sah, R.L.5
  • 7
    • 80054771407 scopus 로고    scopus 로고
    • Cartilage matrix formation by bovine mesenchymal stem cells in three-dimensional culture is agedependent
    • Erickson, I.E., van Veen, S.C., Sengupta, S., Kestle, S.R., and Mauck, R.L. Cartilage Matrix Formation by Bovine Mesenchymal Stem Cells in Three-dimensional Culture Is Agedependent. Clin Orthop Relat Res, 469, 2744, 2011.
    • (2011) Clin Orthop Relat Res , vol.469 , pp. 2744
    • Erickson, I.E.1    Van Veen, S.C.2    Sengupta, S.3    Kestle, S.R.4    Mauck, R.L.5
  • 8
    • 0041358648 scopus 로고    scopus 로고
    • Growth of immature articular cartilage in vitro: Correlated variation in tensile biomechanical and collagen network properties
    • Williamson, A.K., Masuda, K., Thonar, E.J., and Sah, R.L. Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties. Tissue Eng 9, 625, 2003.
    • (2003) Tissue Eng , vol.9 , pp. 625
    • Williamson, A.K.1    Masuda, K.2    Thonar, E.J.3    Sah, R.L.4
  • 9
    • 0018583502 scopus 로고
    • Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization
    • Palmoski, M., Perricone, E., and Brandt, K.D. Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization. Arthritis Rheum 22, 508, 1979.
    • (1979) Arthritis Rheum , vol.22 , pp. 508
    • Palmoski, M.1    Perricone, E.2    Brandt, K.D.3
  • 10
    • 0029098921 scopus 로고
    • Mechanical behavior of articular cartilage in shear is altered by transection of the anterior cruciate ligament
    • Setton, L.A., Mow, V.C., and Howell, D.S. Mechanical behavior of articular cartilage in shear is altered by transection of the anterior cruciate ligament. J Orthop Res 13, 473, 1995.
    • (1995) J Orthop Res , vol.13 , pp. 473
    • Setton, L.A.1    Mow, V.C.2    Howell, D.S.3
  • 11
    • 0024110928 scopus 로고
    • Mechanical and physiocochemical determinants of the chondrocyte biosynthetic response
    • Gray, M.L., Pizzanelli, A.M., Grodzinsky, A.J., and Lee, R.C. Mechanical and physiocochemical determinants of the chondrocyte biosynthetic response. J Orthop Res 6, 777, 1988.
    • (1988) J Orthop Res , vol.6 , pp. 777
    • Gray, M.L.1    Pizzanelli, A.M.2    Grodzinsky, A.J.3    Lee, R.C.4
  • 12
    • 0028245650 scopus 로고
    • The effects of matrix compression on proteoglycan metabolism in articular cartilage explants
    • Guilak, F., Meyer, B.C., Ratcliffe, A., and Mow, V.C. The effects of matrix compression on proteoglycan metabolism in articular cartilage explants. Osteoarthritis Cartilage 2, 91, 1994.
    • (1994) Osteoarthritis Cartilage , vol.2 , pp. 91
    • Guilak, F.1    Meyer, B.C.2    Ratcliffe, A.3    Mow, V.C.4
  • 14
    • 0031830443 scopus 로고    scopus 로고
    • Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression
    • Valhmu, W.B., Stazzone, E.J., Bachrach, N.M., Saed-Nejad, F., Fischer, S.G., Mow, V.C., et al. Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression. Arch Biochem Biophys 353, 29, 1998.
    • (1998) Arch Biochem Biophys , vol.353 , pp. 29
    • Valhmu, W.B.1    Stazzone, E.J.2    Bachrach, N.M.3    Saed-Nejad, F.4    Fischer, S.G.5    Mow, V.C.6
  • 15
    • 0033150597 scopus 로고    scopus 로고
    • Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow
    • Buschmann, M.D., Kim, Y-J., Wong, M., Frank, E., Hunziker, E.B., and Grodzinsky, A.J. Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow. Arch Biochem Biophys 366, 1, 1999.
    • (1999) Arch Biochem Biophys , vol.366 , pp. 1
    • Buschmann, M.D.1    Kim, Y.-J.2    Wong, M.3    Frank, E.4    Hunziker, E.B.5    Grodzinsky, A.J.6
  • 18
    • 33845412455 scopus 로고    scopus 로고
    • Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    • Mauck, R.L., Byers, B.A., Yuan, X, and Tuan, R.S. Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol 6, 113, 2007.
    • (2007) Biomech Model Mechanobiol , vol.6 , pp. 113
    • Mauck, R.L.1    Byers, B.A.2    Yuan, X.3    Tuan, R.S.4
  • 19
    • 33747086508 scopus 로고    scopus 로고
    • Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells
    • Campbell, J.J., Lee, D.A., and Bader, D.L. Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. Biorheology 43, 455, 2006.
    • (2006) Biorheology , vol.43 , pp. 455
    • Campbell, J.J.1    Lee, D.A.2    Bader, D.L.3
  • 20
    • 60149091370 scopus 로고    scopus 로고
    • Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds
    • Pelaez, D., Huang, C.Y., and Cheung, H.S. Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds. Stem Cells Dev 18, 93, 2009.
    • (2009) Stem Cells Dev , vol.18 , pp. 93
    • Pelaez, D.1    Huang, C.Y.2    Cheung, H.S.3
  • 21
    • 65349116649 scopus 로고    scopus 로고
    • Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis
    • Chung, C., and Burdick, J.A. Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. Tissue Eng Part A 15, 243, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 243
    • Chung, C.1    Burdick, J.A.2
  • 22
    • 67650397856 scopus 로고    scopus 로고
    • The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells
    • Chung, C., Beecham, M., Mauck, R.L., and Burdick, J.A. The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. Biomaterials 30, 4287, 2009.
    • (2009) Biomaterials , vol.30 , pp. 4287
    • Chung, C.1    Beecham, M.2    Mauck, R.L.3    Burdick, J.A.4
  • 23
    • 70449657713 scopus 로고    scopus 로고
    • Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels
    • Erickson, I.E., Huang, A.H., Sengupta, S., Kestle, S., Burdick, J.A., and Mauck, R.L. Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. Osteoarthritis Cartilage 17, 1639, 2009.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1639
    • Erickson, I.E.1    Huang, A.H.2    Sengupta, S.3    Kestle, S.4    Burdick, J.A.5    Mauck, R.L.6
  • 24
    • 77950647523 scopus 로고    scopus 로고
    • Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel
    • Huang, A.H., Farrell, M.J., Kim, M., Mauck, R.L. Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater 19, 72, 2010.
    • (2010) Eur Cell Mater , vol.19 , pp. 72
    • Huang, A.H.1    Farrell, M.J.2    Kim, M.3    Mauck, R.L.4
  • 25
    • 0036764695 scopus 로고    scopus 로고
    • Chondrogenic differentiation of human mesenchymal stem cells within an alginate layer culture system
    • Kavalkovich, K.W., Boynton, R.E., Murphy, J.M., and Barry, F. Chondrogenic differentiation of human mesenchymal stem cells within an alginate layer culture system. In Vitro Cell Dev Biol Anim 38, 457, 2002.
    • (2002) Vitro Cell Dev Biol Anim , vol.38 , pp. 457
    • Kavalkovich, K.W.1    Boynton, R.E.2    Murphy, J.M.3    Barry, F.4
  • 26
    • 43549099478 scopus 로고    scopus 로고
    • In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration
    • Hui, T.Y., Cheung, K.M., Cheung, W.L., Chan, D., and Chan, B.P. In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: influence of cell seeding density and collagen concentration. Biomaterials 29, 3201, 2008.
    • (2008) Biomaterials , vol.29 , pp. 3201
    • Hui, T.Y.1    Cheung, K.M.2    Cheung, W.L.3    Chan, D.4    Chan, B.P.5
  • 27
    • 72649099116 scopus 로고    scopus 로고
    • Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner
    • Huang, A.H., Stein, A., Tuan, R.S., and Mauck, R.L. Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A 15, 3461, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 3461
    • Huang, A.H.1    Stein, A.2    Tuan, R.S.3    Mauck, R.L.4
  • 28
    • 33750321974 scopus 로고    scopus 로고
    • Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice
    • Pelttari, K., Winter, A., Steck, E., Goetzke, K., Hennig, T., Ochs, B.G., et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54, 3254, 2006.
    • (2006) Arthritis Rheum , vol.54 , pp. 3254
    • Pelttari, K.1    Winter, A.2    Steck, E.3    Goetzke, K.4    Hennig, T.5    Ochs, B.G.6
  • 29
    • 77952199886 scopus 로고    scopus 로고
    • Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering
    • Scotti, C., Tonnarelli, B., Papadimitropoulos, A., Scherberich, A., Schaeren, S., Schauerte, A., et al. Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci USA 107, 7251, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7251
    • Scotti, C.1    Tonnarelli, B.2    Papadimitropoulos, A.3    Scherberich, A.4    Schaeren, S.5    Schauerte, A.6
  • 30
    • 79960088559 scopus 로고    scopus 로고
    • Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo
    • Bian, L., Zhai, D.Y., Tous, E., Rai, R., Mauck, R.L., and Burdick, J.A. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials 32, 6425, 2011.
    • (2011) Biomaterials , vol.32 , pp. 6425
    • Bian, L.1    Zhai, D.Y.2    Tous, E.3    Rai, R.4    Mauck, R.L.5    Burdick, J.A.6
  • 31
    • 70450284358 scopus 로고    scopus 로고
    • Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model
    • Guo, X., Park, H., Young, S., Kretlow, J.D., van den Beucken, J.J., Baggett, L.S., et al. Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model. Acta Biomater 6, 39, 2010.
    • (2010) Acta Biomater , vol.6 , pp. 39
    • Guo, X.1    Park, H.2    Young, S.3    Kretlow, J.D.4    Van Den Beucken, J.J.5    Baggett, L.S.6
  • 32
    • 0035929599 scopus 로고    scopus 로고
    • Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation
    • Wu, Q-q., Zhang, Y., and Chen, Q. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J Biol Chem 276, 35290, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 35290
    • Wu, Q.-Q.1    Zhang, Y.2    Chen, Q.3
  • 33
    • 2442681981 scopus 로고    scopus 로고
    • Indian hedgehog: A mechanotransduction mediator in condylar cartilage
    • Tang, G.H., Rabie, A.B., and Hagg, U. Indian hedgehog: a mechanotransduction mediator in condylar cartilage. J Dent Res 83, 434, 2004.
    • (2004) J Dent Res , vol.83 , pp. 434
    • Tang, G.H.1    Rabie, A.B.2    Hagg, U.3
  • 34
    • 16644398772 scopus 로고    scopus 로고
    • Cyclic mechanical strain regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2 + channel
    • Tanaka, N., Ohno, S., Honda, K., Tanimoto, K., Doi, T., Ohno-Nakahara, M., et al. Cyclic mechanical strain regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2 + channel. J Dent Res 84, 64, 2005.
    • (2005) J Dent Res , vol.84 , pp. 64
    • Tanaka, N.1    Ohno, S.2    Honda, K.3    Tanimoto, K.4    Doi, T.5    Ohno-Nakahara, M.6
  • 35
    • 57349101756 scopus 로고    scopus 로고
    • Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice
    • Chen, X., Macica, C.M., Nasiri, A., Broadus, A.E. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice. Arthritis Rheum 58, 3788, 2008.
    • (2008) Arthritis Rheum , vol.58 , pp. 3788
    • Chen, X.1    MacIca, C.M.2    Nasiri, A.3    Broadus, A.E.4
  • 36
    • 43949115205 scopus 로고    scopus 로고
    • Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells
    • Mueller, M.B., and Tuan, R.S. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum 58, 1377, 2008.
    • (2008) Arthritis Rheum , vol.58 , pp. 1377
    • Mueller, M.B.1    Tuan, R.S.2
  • 38
    • 54949135803 scopus 로고    scopus 로고
    • Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage
    • Byers, B.A., Mauck, R.L., Chiang, I.E., and Tuan, R.S. Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A 14, 1821, 2008.
    • (2008) Tissue Eng Part A , vol.14 , pp. 1821
    • Byers, B.A.1    Mauck, R.L.2    Chiang, I.E.3    Tuan, R.S.4
  • 39
    • 34548548381 scopus 로고    scopus 로고
    • The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3
    • Lima, E.G., Bian, L., Ng, K.W., Mauck, R.L., Byers, B.A., Tuan, R.S., et al. The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Osteoarthritis Cartilage 15, 1025, 2007.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 1025
    • Lima, E.G.1    Bian, L.2    Ng, K.W.3    Mauck, R.L.4    Byers, B.A.5    Tuan, R.S.6
  • 40
    • 0034210117 scopus 로고    scopus 로고
    • Functional tissue engineering of articular cartilage through dynamic loading of chondrocyteseeded agarose gels
    • Mauck, R.L., Soltz, M.A., Wang, C.C., Wong, D.D., Chao, P.H., Valhmu, W.B., et al. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyteseeded agarose gels. J Biomech Eng 122, 252, 2000.
    • (2000) J Biomech Eng , vol.122 , pp. 252
    • Mauck, R.L.1    Soltz, M.A.2    Wang, C.C.3    Wong, D.D.4    Chao, P.H.5    Valhmu, W.B.6
  • 41
    • 0034210117 scopus 로고    scopus 로고
    • Functional tissue engineering of articular cartilage through dynamic loading of chondrocyteseeded agarose gels
    • Mauck, R.L., Soltz, M.A., Wang, CC-B., Wong, D.D., Chao, P-HG., Valhmu, W.B., et al. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyteseeded agarose gels. J Biomech Eng 122, 252, 2000.
    • (2000) J Biomech Eng , vol.122 , pp. 252
    • Mauck, R.L.1    Soltz, M.A.2    Wang, C.C.-B.3    Wong, D.D.4    Chao, P.-H.G.5    Valhmu, W.B.6
  • 42
    • 0036638517 scopus 로고    scopus 로고
    • Biochemical quantification of DNA in human articular and septal cartilage using. Pico green and Hoechst 33258
    • McGowan, K.B., Kurtis, M.S., Lottman, L.M., Watson, D., and Sah, R.L. Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen and Hoechst 33258. Osteoarthritis Cartilage 10, 580, 2002.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 580
    • McGowan, K.B.1    Kurtis, M.S.2    Lottman, L.M.3    Watson, D.4    Sah, R.L.5
  • 43
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
    • Farndale, R.W., Buttle, D.J., and Barrett, A.J. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochimica et biophysica acta 883, 173, 1986.
    • (1986) Biochimica et Biophysica Acta , vol.883 , pp. 173
    • Farndale, R.W.1    Buttle, D.J.2    Barrett, A.J.3
  • 44
    • 0028328915 scopus 로고
    • Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay
    • Hollander, A.P., Heathfield, T.F., Webber, C., Iwata, Y., Bourne, R., Rorabeck, C., et al. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 93, 1722, 1994.
    • (1994) J Clin Invest , vol.93 , pp. 1722
    • Hollander, A.P.1    Heathfield, T.F.2    Webber, C.3    Iwata, Y.4    Bourne, R.5    Rorabeck, C.6
  • 45
    • 0017739437 scopus 로고
    • Stage-related capacity for limb chondrogenesis in cell culture
    • Ahrens, P.B., Solursh, M., Reiter, R.S. Stage-related capacity for limb chondrogenesis in cell culture. Dev Biol 60, 69, 1977.
    • (1977) Dev Biol , vol.60 , pp. 69
    • Ahrens, P.B.1    Solursh, M.2    Reiter, R.S.3
  • 46
    • 0015122508 scopus 로고
    • The interrelationship of cell density and cartilage thickness in mammalian articular cartilage
    • Stockwell, R.A. The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. J Anat 109, 411, 1971.
    • (1971) J Anat , vol.109 , pp. 411
    • Stockwell, R.A.1
  • 47
    • 0034333644 scopus 로고    scopus 로고
    • Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy
    • Ponticiello, M.S., Schinagl, R.M., Kadiyala, S., and Barry, F.P. Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy. J Biomed Mater Res 52, 246, 2000.
    • (2000) J Biomed Mater Res , vol.52 , pp. 246
    • Ponticiello, M.S.1    Schinagl, R.M.2    Kadiyala, S.3    Barry, F.P.4
  • 49
    • 33747117890 scopus 로고    scopus 로고
    • Spatial and temporal development of chondroctye-seeded agarose constructs in free-swelling and dynamically loaded cultures
    • Kelly, T.N., Ng, K.W., Wang, C-CB., Ateshian, G.A., and Hung, C.T. Spatial and temporal development of chondroctye-seeded agarose constructs in free-swelling and dynamically loaded cultures. J Biomech 39, 1489, 2006.
    • (2006) J Biomech , vol.39 , pp. 1489
    • Kelly, T.N.1    Ng, K.W.2    Wang, C.-C.B.3    Ateshian, G.A.4    Hung, C.T.5
  • 50
  • 51
    • 55549122634 scopus 로고    scopus 로고
    • Dynamic loading of deformable porous media can induce active solute transport
    • Albro, M.B., Chahine, N.O., Li, R., Yeager, K., Hung, C.T., and Ateshian, G.A. Dynamic loading of deformable porous media can induce active solute transport. J Biomech 41, 3152, 2008.
    • (2008) J Biomech , vol.41 , pp. 3152
    • Albro, M.B.1    Chahine, N.O.2    Li, R.3    Yeager, K.4    Hung, C.T.5    Ateshian, G.A.6
  • 52
    • 25444440612 scopus 로고    scopus 로고
    • Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading
    • Huang, C.Y., Reuben, P.M., and Cheung, H.S. Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading. Stem Cells 23, 1113, 2005.
    • (2005) Stem Cells , vol.23 , pp. 1113
    • Huang, C.Y.1    Reuben, P.M.2    Cheung, H.S.3
  • 53
    • 67650538541 scopus 로고    scopus 로고
    • PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
    • Zhang, M., Xie, R., Hou, W., Wang, B., Shen, R., Wang, X., et al. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 122, 1382, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 1382
    • Zhang, M.1    Xie, R.2    Hou, W.3    Wang, B.4    Shen, R.5    Wang, X.6
  • 54
    • 33645082395 scopus 로고    scopus 로고
    • PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and-independent pathways
    • Guo, J., Chung, U.I., Yang, D., Karsenty, G., Bringhurst, F.R., and Kronenberg, H.M. PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and-independent pathways. Dev Biol 292, 116, 2006.
    • (2006) Dev Biol , vol.292 , pp. 116
    • Guo, J.1    Chung, U.I.2    Yang, D.3    Karsenty, G.4    Bringhurst, F.R.5    Kronenberg, H.M.6
  • 55
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., Hammerschmidt, M., and McMahon, A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13, 2072, 1999.
    • (1999) Genes Dev , vol.13 , pp. 2072
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 56
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M., and Tabin, C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613, 1996.
    • (1996) Science , vol.273 , pp. 613
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 57
    • 33750876060 scopus 로고    scopus 로고
    • Effects of TGF-beta1 and triiodothyronine on cartilage maturation: In vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells
    • Mello, M.A., Anf Tuan, R.S. Effects of TGF-beta1 and triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells. J Orthop Res 24, 2095, 2006.
    • (2006) J Orthop Res , vol.24 , pp. 2095
    • Mello, M.A.1    Anf Tuan, R.S.2
  • 58
    • 79952977835 scopus 로고    scopus 로고
    • Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage
    • Bian, L., Zhai, D.Y., Mauck, R.L., and Burdick, J.A. Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Eng Part A 17, 1137, 2011.
    • (2011) Tissue Eng Part A , vol.17 , pp. 1137
    • Bian, L.1    Zhai, D.Y.2    Mauck, R.L.3    Burdick, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.